Preoperative Lateralisation of Aldosterone-Producing Tumours in Primary Aldosteronism

Scoggins, Bruce A.; Oddie, C.J.; Hare, W. S. C.; Coghlan, John P.

doi:10.7326/0003-4819-76-6-391

Cited by 62 publications

(15 citation statements)

References 25 publications

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“…This was later confirmed by others (327). AVS fell out of favor over the next 20 years due to a number of reasons.…”

Section: Adrenal Vein Samplingsupporting

confidence: 51%

Pathophysiology, Diagnosis, and Treatment of Mineralocorticoid Disorders

Magill

2014

Comprehensive Physiology

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The renin-angiotensin-aldosterone system (RAAS) is a major regulator of blood pressure control, fluid, and electrolyte balance in humans. Chronic activation of mineralocorticoid production leads to dysregulation of the cardiovascular system and to hypertension. The key mineralocorticoid is aldosterone. Hyperaldosteronism causes sodium and fluid retention in the kidney. Combined with the actions of angiotensin II, chronic elevation in aldosterone leads to detrimental effects in the vasculature, heart, and brain. The adverse effects of excess aldosterone are heavily dependent on increased dietary salt intake as has been demonstrated in animal models and in humans. Hypertension develops due to complex genetic influences combined with environmental factors. In the last two decades, primary aldosteronism has been found to occur in 5% to 13% of subjects with hypertension. In addition, patients with hyperaldosteronism have more end organ manifestations such as left ventricular hypertrophy and have significant cardiovascular complications including higher rates of heart failure and atrial fibrillation compared to similarly matched patients with essential hypertension. The pathophysiology, diagnosis, and treatment of primary aldosteronism will be extensively reviewed. There are many pitfalls in the diagnosis and confirmation of the disorder that will be discussed. Other rare forms of hyper- and hypo-aldosteronism and unusual disorders of hypertension will also be reviewed in this article.

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“…This was later confirmed by others (327). AVS fell out of favor over the next 20 years due to a number of reasons.…”

Section: Adrenal Vein Samplingsupporting

confidence: 51%

Pathophysiology, Diagnosis, and Treatment of Mineralocorticoid Disorders

Magill

2014

Comprehensive Physiology

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“…An alternative approach that was proposed more than three decades ago [50] entailed the demonstration of increased levels of aldosterone in venous blood draining from the affected adrenal gland through adrenal veins sampling (AVS). This technique proved to be feasible and safe in experienced hands and provides an accurate diagnosis, even in the common occurrence of a small aldosterone-producing tumor, if adequate criteria for the interpretation of results are followed [51].…”

Section: Identification Of Unilateral Causes Of Aldosterone Secretionmentioning

confidence: 99%

Primary aldosteronism: A needle in a haystack or a yellow cab on fifth avenue?

Rossi

2004

Current Science Inc

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“…According to Weinberger et al(1979), the failure rate for right adrenal catheterizations is less than 10% , but the figure given in another report is 38% (Bravo et al, 1983). To avoid catheterization of the right adrenal vein Scoggins et al(1972) compared the aldosterone concentration in the LAV and that in the IVC. Comparison of the A/C ratio for both adrenal veins has been recommended to avoid the second problem (Dunnick et al, 1979;Vaughan et al, 1981;Weinberger et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Localization of Aldosterone-Producing Adenoma: Venous Sampling in Primary Aldosteronism.

et al. 1990

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Adrenal venous sampling of blood was performed for nine patients with aldosterone-producing adenoma (APA). Measurement of adrenal venous aldosterone is useful for localization of APA but difficult, because catheterization of the right adrenal vein is not easy, and the blood is diluted by nonadrenal flow. To solve these problems, levels of aldosterone (A; ng/dl) and cortisol (C; inferior vena cava (IV C), and the LAV A/C and (LAV A/C)/(IVC A/C) ratios were calculated.These ratios were also obtained for 16 patients with essential hypertension.

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Preoperative Lateralisation of Aldosterone-Producing Tumours in Primary Aldosteronism

Cited by 62 publications

References 25 publications

Pathophysiology, Diagnosis, and Treatment of Mineralocorticoid Disorders

Pathophysiology, Diagnosis, and Treatment of Mineralocorticoid Disorders

Primary aldosteronism: A needle in a haystack or a yellow cab on fifth avenue?

Localization of Aldosterone-Producing Adenoma: Venous Sampling in Primary Aldosteronism.

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