Preoperative Irradiation in Management of Locally Advanced Breast Cancer

Delarue, Norman C.; Ash, C L; Peters, Vera; Fielden, Robert

doi:10.1001/archsurg.1965.01320130138016

Cited by 20 publications

(2 citation statements)

References 16 publications

(4 reference statements)

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“…There has been a recent reawakening of interest in use of local irradiation prior to radical mastectomy [3,5]. F letcher [5] reported that vigorous pre-operative irradiation reduced the incidence of 'local recurrence' when the primary tumor and adjacent breast had been 'grossly disturbed by previous incision for biopsy' and in some patients with borderline criteria of operability.…”

Section: Cancer O F the Breastmentioning

confidence: 99%

“…F letcher [5] reported that vigorous pre-operative irradiation reduced the incidence of 'local recurrence' when the primary tumor and adjacent breast had been 'grossly disturbed by previous incision for biopsy' and in some patients with borderline criteria of operability. Patients with 'locally advanced' tumor had an apparent improvement in 5-year survival when preoperatively irradiated, illustrated by 266 T N M Stage III patients having a 5-year survival of 28.2% and a 10-year survival of 13.7% [3].…”

Section: Cancer O F the Breastmentioning

confidence: 99%

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Radiation Therapy for Patients with Metastatic Cancer Primary in the Breast, Colon or Ovary

Parker¹

1970

Oncology

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1. For patients who are potentially curable of cancer of the breast, colon or ovary, radiotherapy can be an effective adjuvant to surgery. The accomplishments of such treatment include: control of regional tumor spread; reduction of metastases incident to manipulation; conversion of a few patients from being inoperable to being operable. Data documenting the contributions of modern radiotherapy are scarce. 2. For patients who, by current knowledge, are not curable of cancer of the breast, colon or ovary, radiotherapy can be an effective palliative agent. Good usage requires specific indications and contraindications, modern techniques, minimization of treatment-produced morbidity, cost and inconvenience.

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Section: Cancer O F the Breastmentioning

confidence: 99%

Section: Cancer O F the Breastmentioning

confidence: 99%

Radiation Therapy for Patients with Metastatic Cancer Primary in the Breast, Colon or Ovary

Parker¹

1970

Oncology

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Breast cancer—Preoperative and postoperative radiation therapy

Powers

1969

Cancer

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Our goal is to develop new methods of breast cancer treatment that produce results better than those usually obtained in patients with operable breast cancer who have a radical mastectomy and patients with inoperable breast cancer who receive desultory and inadequate radiation therapy. We must examine our views “operable patients are curable” and “inoperable patients are incurable” in light of our actual results and recent changes in understanding of the mechanisms of failure to cure breast cancer by surgical treatment and the processes by which radiation therapy cures breast cancer. We must search out ways to increase the cure rate in both operable and inoperable breast cancer patients. Combinations of radiation therapy and surgical resection have been tried with varying successes However, since it is apparent that aggressive radiation therapy cures a significant proportion of patients with inoperable breast cancer,8, 9, 11, 15, 22 it seems reasonable to re‐evaluate this combination therapy and reassess the benefits and failures of such combinations.

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Preoperative irradiation for locally advanced breast cancer

Caldwell

1971

Cancer

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The rationale for preoperative irradiation is sound: eradication of sensitive tumor cells at the periphery of a lesion making complete resection more likely and dissemination of tumor cells by operative manipulation less likely. The dose of irradiation required to achieve this is approximately 80 to 85% of the dose needed to permanently control palpable disease, a dose which does not interfere with subsequent mastectomy healing if 3 to 4 weeks elapse between the conclusion of irradiation and mastectomy. Literature review of series dating back to 1921 indicates that for locally advanced or regionally advanced breast cancer, the preoperative irradiation does reduce local recurrence and probably improves survival as well. A prospective controlled clinical trial to evaluate this more conclusively is needed. Such a trial will require harmonious and honest cooperation between surgeons and radiotherapists.

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Preoperative Irradiation in Management of Locally Advanced Breast Cancer

Cited by 20 publications

References 16 publications

Radiation Therapy for Patients with Metastatic Cancer Primary in the Breast, Colon or Ovary

Radiation Therapy for Patients with Metastatic Cancer Primary in the Breast, Colon or Ovary

Breast cancer—Preoperative and postoperative radiation therapy

Preoperative irradiation for locally advanced breast cancer

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