Preoperative Iron Supplementation and Intraoperative Transfusion During Colorectal Cancer Surgery

Abstract

Iron supplementation for at least 2 weeks before colorectal cancer surgery increases Hb and Ht values in anemic patients, and reduces the need for intraoperative transfusion.

Impact of Perioperative Allogeneic Red Blood Cell Transfusion on Recurrence and Overall Survival After Resection of Colorectal Liver Metastases

“…our results attract notice to blood management measures, including correction of preoperative anemia by administration of iron, recombinant human erythropoietin, folic acid, and vitamin B 12 to avoid aBt. 8,[34][35][36][37][38] Preoperative correction of anemia by those measures could be an auspicious approach for future randomized trials. the application of low transfusion triggers where appropriate may be another approach.…”

Systematic Review and Meta-Analysis: What Is the Evidence for Oral Iron Supplementation in Treating Anaemia in Elderly People?

“…Only one observational study found oral iron was significantly more effective in patients with anaemia than no treatment. Okuyama et al studied 116 anaemic patients undergoing colorectal surgery with a mean age of 67 years [28]. Oral iron increased haemoglobin by 2 g/dL compared with 0.9 g/dL in the control group without iron (p \ 0.001).…”

“…1). Nineteen studies were subsequently excluded as they compared different types of iron supplementation (N = 6) [15,[20][21][22][23][24], involved erythropoietin being simultaneously commenced (N = 3) [25][26][27], were observational studies only (N = 3) [7,28,29], compared groups with a mean age between 29 and 44 years [30,31], included non-anaemic participants (N = 2) [32,33], had no control or placebo group (N = 2) [34,35] or involved only participants between 40 and 55 years of age and no older people (N = 1) [36]. Therefore, only three studies were included in the full review ( Fig.…”

Short course pre-operative ferrous sulphate supplementation – is it worthwhile in patients with colorectal cancer?

“…Two similar studies have previously been conducted. Okuyama et al 11 identified 116 anaemic patients from a cohort of 569, 32 of whom received iron supplementation and the remaining 84 did not. The iron group were less likely to require an intra-operative transfusion.…”