Preoperative globulin‐to‐albumin ratio predicts outcome after curative resection in patients with gastric cancer

Shioiri, Takayuki; Ishizuka, Mitsuru; Shibuya, Norisuke; Tanaka, Genki; Abe, Akihito; Aoki, Taku; Kubota, Keiichi

doi:10.1002/ags3.12200

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…Globulin's involvement in chronic inflammation was observed via elevated levels associated with inflammatory responses and immunosuppression (18). High serum levels of Globulin (GLB) resulted in the poor prognosis of several cancers (19,20). An increase in CRP has been reported in many cancer cases, which reflects the inflammatory and immune response against tumor cells of the human body (21).…”

Section: Discussionmentioning

confidence: 99%

Development of nomograms related to inflammatory biomarkers to estimate the prognosis of bladder cancer after radical cystectomy

Zhang¹,

Yang²,

Kadier³

et al. 2021

Ann Transl Med

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Background: Bladder cancer is one of the most common carcinomas and it brings about huge social economic burden. There is not a reliable way to predict the prognosis of bladder patients. We develop the nomogram to predict the prognosis of bladder cancer patients.Methods: A total of 127 bladder cancer patients after radical cystectomy were studied retrospectively. Their clinicopathological data were collected for statistical analysis.Results: The level of albumin/globulin ratio (AGR), C-reactive protein/albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) associated with pathological and hematological parameters like T stage and hemoglobin. Furthermore, the AGR was associated with overall survival (OS) and CAR, NLR, and PLR were associated with both OS and progression-free survival (PFS) (P<0.05). The multivariate analysis revealed that tobacco smoking, tumor T stage, M stage, NLR, CAR, and AGR were all independent predictors for OS of patients and tobacco smoking, tumor T stage, NLR, CAR, and AGR were independent predictors for PFS of patients. In addition, AGR, CAR, and NLR, as well as, the clinicopathological parameters in the development of nomograms with a C index of 0.901 (95% CI: 0.505-1.269) for OS, and 0.807 (95% CI: 0.755-0.858) for PFS. The nomograms were able to provide a prognosis of the OS with the area under the curve (AUC) =0.86. Further, tests assessed the PFS with the AUC =0.84.Conclusions: This study demonstrates that the nomograms of the inflammatory biomarkers were able to predict prognosis of bladder cancer patients after radical cystectomy.

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Section: Discussionmentioning

confidence: 99%

Development of nomograms related to inflammatory biomarkers to estimate the prognosis of bladder cancer after radical cystectomy

Zhang¹,

Yang²,

Kadier³

et al. 2021

Ann Transl Med

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“…The Albumin-Globulin ratio increased significantly following the bariatric surgery, indicating a rise in albumin in plasma. A study done to observe if Globulin -Albumin ratio is a good predictor for gastric carcinoma following curative resection noted that a low Globulin -Albumin ratio pointed towards a good outcome 70 . They suggested that a raised globulin level in serum reflects tumor progression and antitumor immunity suppression.…”

Section: Discussionmentioning

confidence: 99%

“…Malnutrition, such as obesity (a state of chronic inflammation), causes albumin production suppression 72,73 . Since bariatric surgery promotes weight loss and improved BMI and reduces inflammation, there may be an improvement in the Albumin-Globulin ratio 70,74,75 . Also, following bariatric surgery, toll-like receptors (TLR-2 and TLR-4) expression, nuclear factor kappa β (inflammatory transcription factor), matrix metallopeptidase, and C-reactive protein decrease leading to lowering of systemic inflammation 76,77 .…”

Section: Discussionmentioning

confidence: 99%

Diverted Mini Gastric Bypass Surgery in Obese Population: Out-turn Over Hepatic and Nephrological Parameters

Singh,

Ahmad,

Sinha

et al. 2023

Bangladesh J Med Sci

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Introduction: Bariatric surgery is the best possible option for reducing weight when lifestyle changes and medication have not brought about lasting success and may reduce morbidity and mortality. Weight loss that may follow bariatric surgery in patients on calory restricted diet would result in reduced inflammation and therefore lowering inflammation-related organ damage, including that of the kidney and liver. The study aimed to observe the consequences of BMI change on Hepatic and Nephrological parameters in patients after One Anastomosis Gastric Bypass surgery. Method: This study was done at a bariatric center with 150 individuals (both male and female) aged 20 to 60 years with obesity grades II and III who were selected randomly. Hepatic and renal function tests were carried out at baseline visit, then 3 months and 6 months following surgically. Result: Bilirubin level significantly increased from baseline to visit 1; Serum glutamic-pyruvic transaminase (SGPT) levels significantly decreased at visits 1 and 2. The albumin to Globulin ratio was significantly increased at visit 2 . Blood Urea level and serum creatinine level reduced considerably at visit 1 and decreased more at visit 2 from baseline. Conclusion: Bariatric surgery may be related to improvement in both hepatic and renal function. The improvement may be attributed to reduced inflammatory organ damage related to obesity. More such studies must be performed to highlight the possible health benefits of bariatric surgery for obese patients whose lifestyle modification and medication have not aided in weight loss. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 743-758

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“…NLR and PLR were set at 4 and 180 respectively, according to the previous description and practical situation. 18,25 The F-NLR-PLR score was calculated based on each cutoff value of plasma fibrinogen level, NLR and PLR counts. High plasma fibrinogen level (!4 g/L) was defined as 1, low plasma fibrinogen level (<4 g/L) was calculated as 0.…”

Section: Evaluation Standardmentioning

confidence: 99%

“…Some previous studies mentioned the association between the outcomes and these pretherapeutic inflammatory markers in several malignant tumors and indicated the significance in predicting the prognosis of various malignant tumors. [16][17][18][19] Recent research also found that the combination of these markers has prognostic values. 20,21 Moreover, the latest study demonstrated that high NLR was an unfavor-able predictor of prognosis for older adults with high-grade glioma.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Survival in the Elderly Patients with Glioblastoma using Cumulative Inflammatory Markers Score

Song,

Chen,

et al. 2024

J Neurol Surg B Skull Base

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Objectives This retrospective study aimed to explore the prognostic effect of cumulative score based on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and fibrinogen in older adults diagnosed with glioblastoma (GBM). Design Retrospective study. Setting Huashan Hospital. Participants Patients aged over 60 years and diagnosed with GBM between 2010 and 2017. Main Outcome Measures Results of preoperative routine biochemistry and coagulation blood examinations were reviewed from medical records. Overall survival (OS) was considered a period from first resection surgery until death. Progression-free survival (PFS) was considered a period from initial operation until the date of tumor progression demonstrated in brain magnetic resonance imaging or death from any cause. If no event occurred, the last follow-up appointment was the end of the observation for OS or PFS. The Kaplan–Meier method was used to evaluate survival curves, and prognostic factors were analyzed by the Cox proportional hazards model. Results A total of 289 patients were included. Patients with higher levels of fibrinogen, NLR, and PLR had significantly shorter median OS (p = 0.001, p = 0.016, and p = 0.002, respectively) and PFS (p = 0.004, p = 0.022, and p = 0.009, respectively) compared with those with lower levels. Multivariate analyses showed a significant association between higher F-NLR-PLR score and reduced OS (adjusted hazard ratios [aHRs]: 1.356, 95% confidence interval [CI] 1.009–1.822 for scores 1–2 compared with 0; 5.974, 95% CI 2.811–12.698 for score 3 compared with 0). Similarly, a significant association between higher F-NLR-PLR score and reduced PFS was observed (aHR: 1.428, 95% CI 1.066–1.912 for scores 1–2 compared with 0; aHR: 2.860, 95% CI 1.315–6.223 for score 3 compared with 0). Conclusion Higher F-NLR-PLR score is associated with reduced OS and PFS in older adults with GBM, which helps identify patients at high risk and guide the individualized treatment in clinical practice.

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Preoperative globulin‐to‐albumin ratio predicts outcome after curative resection in patients with gastric cancer

Cited by 7 publications

References 38 publications

Development of nomograms related to inflammatory biomarkers to estimate the prognosis of bladder cancer after radical cystectomy

Development of nomograms related to inflammatory biomarkers to estimate the prognosis of bladder cancer after radical cystectomy

Diverted Mini Gastric Bypass Surgery in Obese Population: Out-turn Over Hepatic and Nephrological Parameters

Prediction of Survival in the Elderly Patients with Glioblastoma using Cumulative Inflammatory Markers Score

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