Preoperative Glasgow Prognostic Score as additional independent prognostic parameter for patients with esophageal cancer after curative esophagectomy

Lindenmann, Joerg; Fink-Neuboeck, Nicole; Avian, Alexander; Pichler, Martin; Habitzruther, M.; Maier, Andrea B.; Smolle‐Jüttner, Freyja‐Maria

doi:10.1016/j.ejso.2016.10.015

Cited by 31 publications

(31 citation statements)

References 27 publications

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“…GPS is an inflammation‐based prognostic score that consists of albumin and CRP levels. GPS has been shown to be useful for prognosis in various cancers . However, to our knowledge, the role of GPS in IPF‐AE has not been previously examined.…”

Section: Discussionmentioning

confidence: 49%

“…GPS has been shown to be useful for prognosis in various cancers. 12,14,16 However, to our knowledge, the role of GPS in IPF-AE has not been previously examined.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that GPS may reliably represent prognostic factors in patients with various malignancies including lung, nasopharyngeal and oesophageal cancer. [11][12][13][14][15][16] However, the prognostic value of GPS in IPF-AE has never been investigated. In the present study, therefore, we evaluated the clinical significance of GPS in IPF-AE patients requiring hospital admission.…”

Section: Summary At a Glancementioning

confidence: 99%

“…The Glasgow prognostic score (GPS) is an inflammation‐based prognostic scoring system that is based on albumin and CRP levels. Recent studies have shown that GPS may reliably represent prognostic factors in patients with various malignancies including lung, nasopharyngeal and oesophageal cancer . However, the prognostic value of GPS in IPF‐AE has never been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

et al. 2017

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Section: Discussionmentioning

confidence: 49%

“…GPS has been shown to be useful for prognosis in various cancers. 12,14,16 However, to our knowledge, the role of GPS in IPF-AE has not been previously examined.…”

Section: Discussionmentioning

confidence: 99%

Section: Summary At a Glancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

et al. 2017

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“…A number of studies have also found similar results for the prognostic role CAR or GPS in various types of cancers. [7][8][9][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] This highlighted the general prognostic role of these two inflammation-based scores in malignancies.…”

Section: Discussionmentioning

confidence: 99%

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

Chen

Liu

Feng

et al. 2020

CMAR

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The prognostic significance of inflammation-based biomarkers for neuroblastoma (NB) has not been investigated before. The aim of this study was to evaluate the prognostic value of pre-treatment inflammation biomarkers in children patients with NB. Patients and Methods: Patients diagnosed with NB from 2008 to 2016 in our institution were enrolled in this study. The clinical data and survival outcomes were retrospectively reviewed. Inflammation biomarkers or scores including C-reactive protein (CRP), albumin (ALB), Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), high-sensitivity modified Glasgow Prognostic Score (Hs-mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and system inflammation index (SII) were tested in this study. Univariate and multivariate survival analyses were performed to assess the prognostic value of these inflammation indicators for overall survival (OS) of children with NB. Kaplan-Meier survival curves were also conducted. Results: A total of 70 children diagnosed with neuroblastoma were enrolled in this study. NLR, PLR, LMR and SII were found to be not predictive of OS for NB patients. However, CRP, ALB, GPS and CAR were significantly associated with OS of NB patients. Multivariate analysis adjusting for age, sex, histology, tumor size, tumor stage and metastasis revealed that ALB, CAR, GPS and Hs-mGPS were significantly associated with OS of NB patients. Receiver operating characteristic (ROC) curves and Akaike Information Criterion (AIC) analyses revealed that Hs-mGPS is superior to other inflammation biomarkers in predicting OS of NB patients. Subgroup survival analysis for immature NB patients revealed similar results. Conclusion: Hs-mGPS is an effective prognostic factor for OS of patients with NB and is promising to be used as a factor for risk stratification and an indicator for more aggressive therapy.

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A nomogram illustrating the probability of anastomotic leakage following cervical esophagogastrostomy

et al. 2020

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Background Early diagnosis of anastomotic dehiscence following cervical esophagogastrostomy may become difficult. Estimation of an individual probability could help to establish preventive and diagnostic measures. The predictive impact of epidemiological, surgery-related data and laboratory parameters on the development of anastomotic dehiscence was investigated in the immediate perioperative period. Methods Retrospective study in 412 patients with cervical esophagogastrostomy following esophagectomy. Epidemiological data, risk factors, underlying disease, pre-treatment- and surgery-related data, C-reactive protein and albumin levels pre-and post-operatively were evaluated. We applied univariable and multivariable logistic regression analysis and developed a nomogram for individual risk assessment. Results There were 345 male, 67 female patients, mean aged 61.5 years; 284 had orthotopic, 128 retrosternal gastric pull-up; 331 patients had carcinoma, 81 non-malignant disease. Mean duration of operation was 184 min; 235 patients had manual, 113 mechanical and 64 semi-mechanical suturing; 76 patients (18.5%) developed anastomotic dehiscence clinically evident at mean 11.4 days after surgery. In univariable testing young age, retrosternal conduit transposition, manual suturing, high body mass index, high ASA and high postoperative levels of C-reactive protein were predictors for anastomotic leakage. These six parameters which had yielded a p < 0.1 in the univariable analysis, were entered into a multivariable analysis and a nomogram allowing the determination of the patient’s individual risk was created. Conclusion By using the nomogram as a supportive measure in the perioperative management, the patient’s individual probability of developing an anastomotic leak could be quantified which may help to take preventive measures improving the outcome.

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Preoperative Glasgow Prognostic Score as additional independent prognostic parameter for patients with esophageal cancer after curative esophagectomy

Cited by 31 publications

References 27 publications

Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

Prognostic significance of Glasgow prognostic score in patients with acute exacerbation of idiopathic pulmonary fibrosis

<p>Prognostic Value of Inflammation Biomarkers for Survival of Patients with Neuroblastoma</p>

A nomogram illustrating the probability of anastomotic leakage following cervical esophagogastrostomy

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