Preoperative findings on non-specific CT in patients with primary acute intestinal ischemia: a case–control study

Straarup, David; Gotschalck, Kåre Andersson; Mikalone, Rasa; Thorlacius-Ussing, Ole

doi:10.1007/s00068-021-01741-w

Cited by 3 publications

(47 citation statements)

References 26 publications

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“…In a study focusing on patients referred for computed tomography -scan without previous clinical suspicion of AMI, radiological changes within the intestinal wall (pneumatosis intestinalis, increased contrast enhancement in the bowel wall), inferior mesenteric artery arteriosclerosis and colonic contraction were predictors of AMI [23].…”

Section: Imagingmentioning

confidence: 99%

Acute mesenteric ischaemia

Blaser

Forbes

Björck

2022

Current Opinion in Critical Care

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Purpose of reviewTo summarize the recent evidence on acute mesenteric ischaemia (AMI).Recent findingsThe overall incidence of AMI is below 10/100 000 person years but increases exponentially with age. The overall mortality of AMI remains high, exceeding 50%, despite continuing progress and increasing availability of imaging and endovascular interventions. However, patients with (early) revascularization have significantly better outcomes. The majority of patients surviving the acute event are still alive at 1 year, but evidence on quality of life is scarce.Clinical suspicion of AMI is the key to timely diagnosis, with biphasic computed tomography-angiography the diagnostic method of choice. Currently, no biomarker has sufficient specificity to diagnose AMI.SummaryImproved awareness and knowledge of AMI are needed to raise the suspicion of AMI in relevant patients and thereby to achieve better outcomes.

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Section: Imagingmentioning

confidence: 99%

Acute mesenteric ischaemia

Blaser

Forbes

Björck

2022

Current Opinion in Critical Care

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“…Initial analytical considerations were built on cut-off levels in the literature as mentioned. Due to a much lower cut-off in our data considerable analytical noise due to lipemic interference was encountered, excluding roughly half of the AIN and control patients from the analysis (170).…”

Section: Preparation and Analysis Of Blood Samplesmentioning

confidence: 98%

“…An initial CT scan was explored, including phases (noncontrast, arterial-, portovenous phase and combinations) and AIN suspicion status in the referral and radiological report. Additionally, the CT scans were re-evaluated by an experienced gastrointestinal radiologist registering radiological findings in relation to the vasculature, intestine, and extraintestinal findings (169).…”

Section: Data Collectionmentioning

confidence: 99%

“…Study two was designed as a cross-sectional case-control study exploring D-lactate elevation as a predictor of AIN case status compared to a large group of non-AIN surgical patients with abdominal pain suffering from a wide variety of surgical diseases. Due to a low number of AIN patients, additional in-hospital high-risk patients suspected to suffer from AIN were included in the study (170).…”

Section: Studies 2 and 3 421 Study Designmentioning

confidence: 99%

“…Surgical verification of acute intestinal necrosis or ischaemia was retrospectively registered from the surgical report. Control patients were defined as non-AIN patients in the same cohort (170,171).…”

Section: Patient Selectionmentioning

confidence: 99%

See 2 more Smart Citations

Acute Intestinal Necrosis: The Preoperative Diagnostic Approach: Particularly References to Acute Vascular Intestinal Necrosis

Straarup

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Standing in a proud tradition of research with constant development in numerous medical fields, the feeling of "standing" is more appropriate than "progressing" regarding the research of diagnosing acute intestinal necrosis (AIN). After a century where the prognosis and treatment have evolved for AIN patients, the statement of Cokkinis remains painfully relevant due to the diagnostic process. The search for a blood-based biomarker has for decades been a desert walk. Similarly, despite "sensitivity and specificity rates of 1.00" of an abdominal CT scan with respect to AIN, no general change in mortality has occurred.Growing from this painful experience in my own clinical work with AIN patients, this study is a humble supplement to the fight against its terribly high mortality rate.This study explores radiological findings in the most difficult AIN patients and tries to settle research questions in some proposed blood-based biomarkers and to add support to other biomarker research through 3 studies in AIN patients.

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Acute mesenteric ischemia: diagnostic and therapeutic challenges

Demetriades

2023

Eur J Trauma Emerg Surg

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Preoperative findings on non-specific CT in patients with primary acute intestinal ischemia: a case–control study

Cited by 3 publications

References 26 publications

Acute mesenteric ischaemia

Acute mesenteric ischaemia

Acute Intestinal Necrosis: The Preoperative Diagnostic Approach: Particularly References to Acute Vascular Intestinal Necrosis

Acute mesenteric ischemia: diagnostic and therapeutic challenges

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