Preoperative Evaluation of Sellar and Parasellar Macrolesions by [ 18 F]Fluorodeoxyglucose Positron Emission Tomography

Tosaka, Masahiko; Higuchi, Tetsuya; Horiguchi, Keishi; Osawa, Tadashi; Arisaka, Yukiko; Fujita, Hiroaki; Tsushima, Yoshito; Yoshimoto, Yuhei

doi:10.1016/j.wneu.2017.04.032

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…However, magnetic resonance imaging is the imaging technique of choice, as it produces multiplanar high-contrast images, while more recent advanced magnetic resonance imaging techniques such as diffusion-weighted imaging and perfusion-weighted imaging [3][4][5] can better define the morphological characteristics of the lesion. 18 F-fluoro-deoxyglucose and 68 Ga-positron emission tomography can be used for functional imaging, but only in specific tumour settings [6,7].…”

Section: Introductionmentioning

confidence: 99%

Late Effects of Parasellar Lesion Treatment: Hypogonadism and Infertility

et al. 2020

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Central hypogonadism, also defined as hypogonadotropic hypogonadism, is a recognized complication of hypothalamic-pituitary-gonadal axis damage following treatment of sellar and parasellar masses. In addition to radiotherapy and surgery, CTLA4-blocking antibodies and alkylating agents such as temozolomide can also lead to hypogonadism, through different mechanisms. Central hypogonadism in boys and girls may lead to pubertal delay or arrest, impairing full development of the genitalia and secondary sexual characteristics. Alternatively, cranial irradiation or ectopic hormone production may instead cause early puberty, affecting hypothalamic control of the gonadostat. Given the reproductive risks, discussion of fertility preservation options and referral to reproductive specialists before treatment is essential. Steroid hormone replacement can interfere with other replacement therapies and may require specific dose adjustments. Adequate gonadotropin stimulation therapy may enable patients to restore gametogenesis and conceive spontaneously. When assisted reproductive technology is needed , protocols must be tailored to account for possible long-term gonadotropin insufficiency prior to stimulation. The aim of this review was to provide an overview of the risk factors for hypogonadism and infertility in patients treated for parasellar lesions and to give a summary of the current recommendations for management and follow-up of these dysfunctions in such patients. We have also briefly summarized evidence on the physiological role of pituitary hormones during pregnancy, focusing on the management of pituitary deficiencies.

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Section: Introductionmentioning

confidence: 99%

Late Effects of Parasellar Lesion Treatment: Hypogonadism and Infertility

et al. 2020

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“…Regarding pituitary adenoma, findings that are occasionally observed and are suggestive of pituitary adenoma include cystic degeneration, hemorrhage, and heterogeneous contrast enhancement. Regarding third-ventricle meningioma, low 18 F-FDG uptake can be a differential point 2 . We found that the combination of 18 F-FDG PET/CT and MRI is useful for diagnosing PCP.…”

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confidence: 82%

“…Nagata et al 1 suggested that PCP could be included in the differential diagnosis of suprasellar tumors with high 18 F-FDG uptake. In their study of 11 craniopharyngioma patients, Tosaka et al 2 reported that the 18 F-FDG uptake in the PCPs was significantly higher than that of the adenomatous type. Regarding other PET tracers, Zhu et al 3 reported a case of 18 F-choline uptake in the third ventricular PCP on PET/CT, and they suggested that craniopharyngioma should be included in the differential diagnosis of 18 F-choline–avid brain lesions.…”

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confidence: 96%

“…It has been shown to affect multiple signal pathways that upregulate glucose transport and glycolysis, thus facilitating tumor growth, which may be related to the high 18 F-FDG uptake in PCP. 2,7,8 We speculate that 18 F-FDG PET/CT could be a monitor for evaluating the treatment of PCPs with BRAF inhibitors. 9 The main differential diagnosis of PCP extends to chordoid glioma of the third ventricle, because this tumor and PCP present similar MRI features.…”

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confidence: 97%

“…The other differential diagnoses are malignant lymphoma, ectopic pituitary adenoma, and meningioma. Although malignant lymphoma and pituitary adenoma are high- 18 F-FDG-avidity tumors, 1,2,13 a low apparent diffusion coefficient value (hyperintensity on DWI) on MRI indicates malignant lymphoma 14 . Regarding pituitary adenoma, findings that are occasionally observed and are suggestive of pituitary adenoma include cystic degeneration, hemorrhage, and heterogeneous contrast enhancement.…”

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confidence: 99%

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High 18F-FDG Uptake in a Papillary Craniopharyngioma of the Third Ventricle

Kaida

Matsukubo

et al. 2023

Clin Nucl Med

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Craniopharyngioma is a benign tumor classified as grade 1 by the World Health Organization Classification of Tumors of the Central Nervous System. We present a rare case of a high-18F-FDG-avidity papillary craniopharyngioma of the third ventricle. A 65-year-old man underwent CT and MRI examinations for gait disturbance, lower-limb weakness, and urinary incontinence, and an oval solid tumor that extended from the suprasellar region to the third ventricle was identified. 18F-FDG PET/CT showed high accumulation (SUVmax, 22.3) in the tumor. A transventricular endoscopic tumor biopsy led to the diagnosis of papillary craniopharyngioma.

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Pituitary metastasis from renal cell carcinoma presenting with significant hyperprolactinemia, case report

Mazar‐Atabaki,

Mohamadzadeh,

Sadrehosseini

et al. 2023

Clinical Case Reports

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Key Clinical MessageKidney metastasis to the pituitary gland can cause hyperprolactinemia even above 250 ng/mL. Although the treatment of metastasis is palliative, surgical decompression could play a major role in the recovery of symptoms and improve quality of life. Pituitary metastasis should be considered in the evaluation of an unusual pituitary mass.AbstractPituitary tumors are frequently encountered in the neurosurgical setting. Although the majority of them are pituitary adenomas, rare entities encompass pituitary metastasis. They should be differentiated from pituitary adenomas because their management and prognosis are different. We report a 53‐year‐old female who complained of headache and had remarkable hyperprolactinemia (271.1 ng/mL). Having considered macroprolactinoma as the initial diagnosis, medical treatment was initiated with Cabergoline. Subsequently, the patient's vision deteriorated which prompted us to perform endoscopic endonasal transsphenoidal surgery. Histologic examination of the resected tumor revealed metastatic renal cell carcinoma. Main treatment for these subjects is palliative; and unlike the pituitary adenoma, the prognosis is unfortunately poor. Pituitary metastasis should be considered in the evaluation of an unusual pituitary mass associated with hyperprolactinemia.

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Preoperative Evaluation of Sellar and Parasellar Macrolesions by [ 18 F]Fluorodeoxyglucose Positron Emission Tomography

Cited by 10 publications

References 31 publications

Late Effects of Parasellar Lesion Treatment: Hypogonadism and Infertility

Late Effects of Parasellar Lesion Treatment: Hypogonadism and Infertility

High 18F-FDG Uptake in a Papillary Craniopharyngioma of the Third Ventricle

Pituitary metastasis from renal cell carcinoma presenting with significant hyperprolactinemia, case report

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