Preoperative evaluation of sarcopenia in patients with colorectal cancer: a prospective study

Nunes, Giovana Domingues; Cardenas, Letícia Zumpano; Miola, Thais Manfrinato; Souza, Juliana de Oliveira; Carniatto, Letícia Nascimento; Bitencourt, Almir Galvão Vieira

doi:10.1590/1806-9282.20220339

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Colorectal cancer (CRC) is a disease of high prevalence and great impact on global health, being the third most commonly diagnosed cancer worldwide and the second leading cause of cancer death ( 44 ). Abdominal CT must be routinely performed in colorectal cancer for diagnosis, staging and follow-up ( 17 , 45 , 46 ).…”

Section: Introductionmentioning

confidence: 99%

Body composition assessment with ultrasound muscle measurement: optimization through the use of semi-automated tools in colorectal cancer

Palmas,

Mucarzel,

Ricart

et al. 2024

Front. Nutr.

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Colorectal cancer (CRC) is a disease with a high prevalence and major impact on global health. Body composition (BC) data are of great importance in the assessment of nutritional status. Ultrasound (US) is an emerging, accessible and non-invasive technique that could be an alternative when it is not feasible to perform computed tomography (CT). The aim of this study is to evaluate the correlation between CT, as a reference technique, and US of the rectus femoris (RF) as a “proof of concept,” in a cohort of patients with CRC and assess the optimisation of results obtained by US when performed by our new semi-automated tool. A single-centre cross-sectional study including 174 patients diagnosed with CRC and undergoing surgery was carried out at the Vall d’Hebron Hospital. We found a strong correlation between CT and US of the RF area (r = 0.67; p < 0.005). The latter, is able to discriminate patients with worse prognosis in terms of length of hospital stay and discharge destination (AUC-ROC = 0.64, p 0.015). These results improve when they are carried out with the automatic tool (area AUC-ROC = 0.73, p 0.023), especially when normalised by height and eliminating patients who associate overflow. According to our results, the US could be considered as a valuable alternative for the quantitative assessment of muscle mass when CT is not feasible. These measurements are improved when measuring software is applied, such as “Bat” software.

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Section: Introductionmentioning

confidence: 99%

Body composition assessment with ultrasound muscle measurement: optimization through the use of semi-automated tools in colorectal cancer

Palmas,

Mucarzel,

Ricart

et al. 2024

Front. Nutr.

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Accuracy of surgeons for predicting radiological sarcopenia in colorectal cancer surgery

Gonçalves,

de Barros,

Castro

et al. 2024

Journal of Surgical Oncology

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BackgroundThis study explored the performance of surgeons for predicting radiological sarcopenia as accessed by psoas cross‐sectional area in patients with colorectal cancer (CRC).MethodsA cross‐sectional study was carried out and a diagnostic accuracy strategy was applied using the radiologist team assessment as gold standard.ResultsCohort analysis of 45 consecutive patients found that 31.1% had sarcopenia. Correlation of Total Psoas Index between radiologists and surgeons was very strong for the Junior and strong for the Senior surgeon, with a strong correlation between the surgeons. By the simplistic criterion, agreement between radiologists and surgeons was substantial for both the Junior and Senior surgeons, with a moderate level between the surgeons. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Junior surgeon were 92.9%, 83.9%, 72.2%, 96.3%, and 86.7%, respectively. The corresponding results for the Senior surgeon were 78.6%, 90.3%, 78.6%, 90.3%, and 86.7%, respectively. We found no major differences on agreement levels and performance of surgeons using the composite criterion.ConclusionsSurgeons seem to be accurate for identifying radiological sarcopenia in patients with CRC. The simplistic criterion should be preferred since a composite criterion adds complexity without increasing accuracy or agreement levels.

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The relationship between preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score and right colon cancer surgery outcomes: a retrospective cohort study

Ay,

Erol,

Arıcı

et al. 2024

Eur Res J

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Objectives: This study aims to investigate the association between the preoperative Hemoglobin Albumin Lymphocyte Platelet (HALP) score and surgical outcomes in right colon cancer patients. Methods: This retrospective cohort study included patients undergoing elective right colon adenocarcinoma surgery from January 2017 to June 2023 at Bursa Yuksek Ihtisas Training and Research Hospital. The HALP score, calculated from hemoglobin, albumin, lymphocyte, and platelet levels, aimed to predict perioperative morbidity through receiver operating characteristic (ROC) curve analysis. Results: The study involved 67 patients, mostly male with an average age of 68.28 years, undergoing 46 open and 21 laparoscopic surgeries. Although the HALP score's cutoff value was established, it did not significantly predict perioperative morbidity (P>0.05). However, lower platelet counts (<318×103/L) and open surgery type correlated significantly with higher morbidity (P<0.05). Conclusions: This study reveals that the HALP score may not effectively predict perioperative morbidity in right colon cancer surgeries, highlighting platelet counts as a more promising marker. Our findings also confirm the increased morbidity associated with open surgeries, challenging existing assumptions and guiding clinical practice.

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Preoperative evaluation of sarcopenia in patients with colorectal cancer: a prospective study

Cited by 3 publications

References 29 publications

Body composition assessment with ultrasound muscle measurement: optimization through the use of semi-automated tools in colorectal cancer

Body composition assessment with ultrasound muscle measurement: optimization through the use of semi-automated tools in colorectal cancer

Accuracy of surgeons for predicting radiological sarcopenia in colorectal cancer surgery

The relationship between preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) score and right colon cancer surgery outcomes: a retrospective cohort study

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