Preoperative evaluation of osteosarcoma: value of gadopentetate dimeglumine-enhanced MR imaging.

Seeger, Leanne L.; Widoff, B E; Bassett, Lawrence W.; Rosen, G.; Eckardt, Jeffery J.

doi:10.2214/ajr.157.2.1853820

Cited by 79 publications

(13 citation statements)

References 2 publications

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“…In both benign and malignant tumors, enhancement of marrow and soft tissue edema was equal to or more than that of tumor tissue. This is corroborated by the findings of Seeger and coworkers [32]. We do not know the precise cause of this phenomenon.…”

Section: Discussionsupporting

confidence: 64%

MR imaging of edema accompanying benign and malignant bone tumors

et al. 1994

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To evaluate the incidence, quantity, and presentation of intra- and extraosseous edema accompanying benign and malignant primary bone lesions, the magnetic resonance (MR) studies of 63 consecutive patients with histologically proven primary bone tumors were reviewed. MR scans were assessed for the presence and quantity of marrow and soft tissue edema and correlated with peroperative findings, resected specimens and follow-up data. The signal intensity and enhancement of tumor and edema prior to and after intravenous administration (if any) of gadolinium-labeled diethylene triamine pentaacetate (Gd-DTPA) was analyzed. Marrow edema was encountered adjacent to 8 of 39 malignant tumors and 14 of 24 benign lesions. Soft tissue edema was found accompanying 28 of 39 malignancies and 10 of 24 benign disorders. On unenhanced T1-weighted MR images tumor and edema were difficult to differentiate. Tumor inhomogeneity made this differentiation easier on T2-weighted sequences. In 36 patients the contrast medium Gd-DTPA was used. Edema was present in 27 of these patients and the respective enhancement of tumor and edema could be compared. Edema always enhanced homogeneously, and in most cases it enhanced to a similar degree as or more than tumor. Marrow and, more specifically, soft tissue edema is a frequent finding adjacent to primary bone tumors. The mere presence and quantity of marrow and soft tissue edema are unreliable indicators of the biologic potential of a lesion. Unenhanced MR scans cannot always differentiate between tumor and edema, but the administration of Gd-DTPA is of assistance in differentiating tumor from edema.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 64%

MR imaging of edema accompanying benign and malignant bone tumors

et al. 1994

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“…Radiological examination with CT or MR imaging showed joint invasion in 22-32% of bone sarcomas (Bloem et al 1988, Schurawitzki et al 1989, Seeger et al 1991, Schima et al 1994). In our study, rates for hip joint in ltration varied with the diagnosis; almost half of the CSs, one tenth of the OSs, but none of the 12 ESs showed histological evidence of an intraarticular tumor.…”

Section: Discussionmentioning

confidence: 98%

Infiltration of sarcomas into the hip joint: Comparison of CT, MRI and histologic findings in 67 cases

Ozaki

Putzke

Bürger

et al. 2002

Acta Orthopaedica Scandinavica

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“…Of note, non-dynamic imaging is not reliably helpful in this regard. 13 '14 Awareness of peritumoral edema and means to facilitate its recognition is important to avoid overstaging the soft tissue extent of a sarcoma at …”

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confidence: 99%