Preoperative Estimated Glomerular Filtration Rate is an Independent Predictor of Late Cardiovascular Morbidity after Mitral Valve Surgery

Nakazato, Taro; Nakamura, Teruya; Sekiya, Naosumi; Sawa, Yoshiki

doi:10.5761/atcs.oa.13-00187

Cited by 5 publications

(2 citation statements)

References 24 publications

(22 reference statements)

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“…Some studies have reported that preoperative renal insufficiency was associated with increased postoperative complications after various types of surgery including cardiac and general surgery . Furthermore, large‐scale retrospective analyses have also demonstrated severe preoperative renal insufficiency as an independent risk factor associated with increased risk of morbidity after pancreatic resection, although the precise mechanisms are not yet known in any type of surgery .…”

Section: Discussionmentioning

confidence: 99%

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Impact of preoperative asymptomatic renal dysfunction on clinical course after pancreatoduodenectomy

Nagai

Sho

Akahori

et al. 2015

J Hepatobiliary Pancreat Sci

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Background Although recent large-scale clinical studies have shown that preoperative renal insufficiency is associated with increased risk of postoperative complications after pancreatoduodenectomy (PD), it is unknown whether asymptomatic renal dysfunction has an impact on postoperative course after PD. Methods Two hundred and fifty-four patients who underwent PD between 2007 and 2013 were enrolled. Renal function was evaluated by the preoperative estimated glomerular filtration rate (eGFR). Patients were divided into two groups according to the cutoff value of 55 of eGFR. Results Thirty-five patients were classified as the low eGFR group, while 219 were classified as the normal group. There were differences between groups in age, comorbidity and pancreatic texture. The incidence of overall postoperative complication, grade B/C pancreatic fistula and severe complication in the low eGFR group was significantly higher than that in the normal group. Multivariate analysis identified low eGFR as an independent risk factor for severe postoperative complications and grade B/C pancreatic fistula after PD. However, there were no differences in mortality and survival between the low and normal eGFR groups. ConclusionsWe have demonstrated for the first time that preoperative asymptomatic renal dysfunction may be a significant risk factor for severe morbidity and clinically relevant pancreatic fistula after PD.

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Section: Discussionmentioning

confidence: 99%

“…Preoperative renal insufficiency is a well‐known risk factor for postoperative complications after cardiac and vascular surgery . Furthermore, a few recent large‐scale clinical studies have also shown the negative impact of preoperative renal insufficiency on postoperative outcomes after pancreatic resection .…”

Section: Introductionmentioning

confidence: 99%