Preoperative epidural fentanyl reduces postoperative pain after upper abdominal surgery

Doi, Kouki; Yamanaka, Manami; Shono, Atsuko; Fukuda, Noriko; Saito, Yoji

doi:10.1007/s00540-007-0519-9

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Prevalence of maternal adverse reactions (sedation, pruritus, nausea, and vomiting) and use of supplemental analgesics and medication for adverse reactions were gathered from nursing records. An anesthesiologist visited patients on postoperative day (POD) 1 and 2, and assessed pain with the Prince Henry Pain Scale (PHPS) [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

Intrathecal Administration of Morphine Decreases Persistent Pain after Cesarean Section: A Prospective Observational Study

et al. 2016

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PurposeChronic pain after cesarean section (CS) is a serious concern, as it can result in functional disability. We evaluated the prevalence of chronic pain after CS prospectively at a single institution in Japan. We also analyzed perioperative risk factors associated with chronic pain using logistic regression analyses with a backward-stepwise procedure.Materials and MethodsPatients who underwent elective or emergency CS between May 2012 and May 2014 were recruited. Maternal demographics as well as details of surgery and anesthesia were recorded. An anesthesiologist visited the patients on postoperative day (POD) 1 and 2, and assessed their pain with the Prince Henry Pain Scale. To evaluate the prevalence of chronic pain, we contacted patients by sending a questionnaire 3 months post-CS.ResultsAmong 225 patients who questionnaires, 69 (30.7%) of patients complained of persistent pain, although no patient required pain medication. Multivariate analyses identified lighter weight (p = 0.011) and non-intrathecal administration of morphine (p = 0.023) as determinant factors associated with persistent pain at 3 months. The adjusted odds ratio of intrathecal administration of morphine to reduce persistent pain was 0.424, suggesting that intrathecal administration of morphine could decrease chronic pain by 50%. In addition, 51.6% of patients had abnormal wound sensation, suggesting the development of neuropathic pain. Also, 6% of patients with abnormal wound sensation required medication, yet no patients with persistent pain required medication.ConclusionAlthough no effect on acute pain was observed, intrathecal administration of morphine significantly decreased chronic pain after CS.

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Section: Methodsmentioning

confidence: 99%

Intrathecal Administration of Morphine Decreases Persistent Pain after Cesarean Section: A Prospective Observational Study

et al. 2016

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“…Postoperative pain is an important postoperative complication which can cause great sufferings to patients. Fentanyl has obvious analgesic effect, and has little influence on visceral functions, so it is widely used for postoperative analgesia in patients after abdominal surgeries [ 2 ]. However, there are significant individual differences in the postoperative consumption and analgesic effect of fentanyl [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of ADRB1 rs1801253 Polymorphism with Analgesic Effect of Fentanyl After Cancer Surgeries

et al. 2015

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BackgroundOur study aimed to explore the association between β1-adrenoceptor (ADRB1) rs1801253 polymorphism and analgesic effect of fentanyl after cancer surgeries in Chinese Han populations.Material/MethodsPostoperative fentanyl consumption of 120 patients for analgesia was recorded. Genotype distributions were detected by allele specific amplification-polymerase chain reaction (ASA-PCR) method. Postoperative pain was measured by visual analogue scale (VAS) method. Differences in postoperative VAS score and postoperative fentanyl consumption for analgesia in different genotype groups were compared by analysis of variance (ANOVA). Preoperative cold pressor-induced pain test was also performed to test the analgesic effect of fentanyl.ResultsFrequencies of Gly/Gly, Gly/Arg, Arg/Arg genotypes were 45.0%, 38.3%, and 16.7%, respectively, and passed the Hardy-Weinberg Equilibrium (HWE) test. The mean arterial pressure (MAP) and the heart rate (HR) had no significant differences at different times. After surgery, the VAS score and fentanyl consumption in Arg/Arg group were significantly higher than in other groups at the postoperative 2nd hour, but the differences were not obvious at the 4th hour, 24th hour, and the 48th hour. The results suggest that the Arg/Arg homozygote increased susceptibility to postoperative pain. The preoperative cold pressor-induced pain test suggested that individuals with Arg/Arg genotype showed worse analgesic effect of fentanyl compared to other genotypes.ConclusionsIn Chinese Han populations, ADRB1 rs1801253 polymorphism might be associated with the analgesic effect of fentanyl after cancer surgery.

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Neuraxial Analgesia with Hydromorphone, Morphine, and Fentanyl: Dosing and Safety Guidelines

Dabu-Bondoc¹,

Franco²,

Sinatra³

2009

Acute Pain Management

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Preoperative epidural fentanyl reduces postoperative pain after upper abdominal surgery

Cited by 3 publications

References 18 publications

Intrathecal Administration of Morphine Decreases Persistent Pain after Cesarean Section: A Prospective Observational Study

Intrathecal Administration of Morphine Decreases Persistent Pain after Cesarean Section: A Prospective Observational Study

Correlation of ADRB1 rs1801253 Polymorphism with Analgesic Effect of Fentanyl After Cancer Surgeries

Neuraxial Analgesia with Hydromorphone, Morphine, and Fentanyl: Dosing and Safety Guidelines

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