Preoperative elevation of serum C‐reactive protein as an indicator of poor prognosis for early‐stage esophageal squamous cell carcinoma

Song, Zhengbo; Lin, Bing; Li, Bo; He, Chunxiao; Zhang, Beibei; Shao, Lan; Zhang, Yiping

doi:10.1016/j.kjms.2013.01.016

Cited by 17 publications

(16 citation statements)

References 15 publications

(18 reference statements)

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“…After further investigating the studies, 24 studies were screened out due to insufficient data or different cancers. Finally, 11 studies were eligible for meta-analysis (Nozoe et al, 2001;Ikeda et al, 2003;Shimada et al, 2003;Guillem et al, 2005;Gockel et al, 2006;Wang et al, 2009;Fujiwara et al, 2011;Miyata et al, 2011;Feng et al, 2013;Meng et al, 2013;Song et al, 2013). The flow chart of search process was shown in Figure 1.…”

Section: Search Resultsmentioning

confidence: 99%

“…Some researches showed that the overall survival (OS) was significantly shorter in the esophageal cancer patients with elevated serum CRP level (Feng et al, 2013;Song et al, 2013). However, some researches showed that the correlation between elevated serum CRP level and shorter OS was not statistically significant (Miyata et al, 2011).…”

Section: Tian-liang Zhengmentioning

confidence: 99%

“…Eight studies reported the relationship between serum CRP level and OS in esophageal cancer patients (Nozoe et al, 2001;Ikeda et al, 2003;Shimada et al, 2003;Wang et al, 2009;Miyata et al, 2011;Feng et al, 2013;Meng et al, 2013;Song et al, 2013). The heterogeneity (Figure 2).…”

Section: Serum Crp Level and Os In Esophageal Cancermentioning

confidence: 99%

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Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Zheng

Cao²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The classical inflammatory biomarker, C-reactive protein (CRP), has been identified to be related to progression of esophageal cancer. Some research showed that elevated pretreatment serum CRP indicated a poor prognosis, but results have been inconsistent. Materials and Methods: We searched the Medline, Embase and the Cochrane Central Search Library for suitable studies and a meta-analysis of eleven (1,886 patients) was conducted to examine the relationship between elevated serum CRP level and overall survival (OS) in esophageal cancer cases. Moreover, correlation analyses were conducted to assess links between pretreatment serum CRP level and tumor node metastasis (TNM) stage as well as T, N, M grade, respectively. Results: The pooled analysis showed that elevated pretreatment serum CRP level was significantly associated with poorer overall survival (HR 2.09, 95%CI 1.52-2.87, p<0.01). Subgroup analyses were conducted by "country", "cut-off value", "treatment" and "number of patients", and no single factor could alter the result. Elevated pretreatment serum CRP was significantly correlated with more advanced TNM stage and T, N, M grade respectively. Conclusions: Elevated pretreatment serum CRP levels are associated with poorer prognosis in esophageal cancer patients, and could serve as a useful biomarker for outcome prediction.

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Section: Search Resultsmentioning

confidence: 99%

Section: Tian-liang Zhengmentioning

confidence: 99%

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Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Zheng

Cao²,

Cui³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…As a sensitive and undeniable prognostic marker for systemic inflammation, CRP has been shown to be significant in the prediction of outcomes of head and neck squamous cell carcinoma 22, oesophageal squamous cell carcinoma 23, pancreatic cancer patients 14, and metastatic nasopharyngeal carcinoma 24. The production of CRP by the liver is strongly induced by cytokines (including interleukin-1, interleukin-6, and tumour-necrosis factor), which recruit and suppress anti-tumour immune cells 25.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal Carcinoma

Wang

Chen

et al. 2016

J. Cancer

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Background: The C-reactive protein/albumin (CRP/ALB) ratio has recently been associated with clinical outcomes in patients suffering various types of cancer. In this retrospective study, we investigated the prognostic value of the pre-treatment CRP/ALB ratio (CAR) in non-metastatic nasopharyngeal carcinoma (NPC) patients.Methods: The cohort included 2685 patients with non-metastatic NPC. Univariate and multivariate COX proportional hazards analyses were applied to evaluate the associations of CAR with overall survival (OS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and locoregional recurrence-free survival (LRRFS) in patients with NPC. Kaplan-Meier survival analyses was used to compare groups classified by CAR.Results: Patients were categorised by the CAR using a cut-off value of 0.064. Multivariate Cox proportional hazard analysis verified that high CAR level was a significant predictor for inferior OS (P = 0.003), DMFS (P = 0.035), and LRRFS (P = 0.024), but not for DFS (P = 0.093). CAR was also an independent prognostic factor for OS when stratified by Epstein-Barr virus DNA level ( ≥ 2560 or < 2560 copies ml-1).Conclusions: High CAR provides prognostication regarding OS, DMFS, DFS, and LRRFS in patients with NPC. CAR is a valuable coadjutant for Epstein-Barr virus DNA levels for identifying survival differences.

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“…Some researchers showed that the overall survival (OS) was significantly shorter in the EC patients with elevated serum CRP level. 17,18 However some researches showed that the correlation between elevated serum CRP level and shorter OS was not statistically significant. 19 Due to the small sample size of the individual studies, the current opinion is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of serum C-reactive protein in carcinoma oesophagus

2019

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Background: Oesophageal cancer (EC) is the eighth most common cancer around the world. EC incidence and mortality are affected by geography. Eastern Asia, eastern and southern Africa has the highest rates, whereas Europe and North America show lower rates.Methods: The study was conducted on 30 cases of EC diagnosed in Sri Guru Ram Das Institute of Medical Sciences and Research, Sri Amritsar. The study was carried during period starting from January 2017 to June 2018. Serum C - reactive protein levels measurement was made in addition to the other routine investigations.Results: The sample consisted of 30 patients presenting with EC. Total number of males was 7 (23.33%) and there were 23 (76.66%) females. It was found in present study that the most common age group presenting with oesophageal cancer was 41-60 years followed by 61-80 years. It was also observed in the present study that majority of patients 15 (50%) were housewives. It was also observed that 17 (56.67%) of patients had more than 6 mg/l level of preoperative C-reactive proteins. Among the poorly differentiated histological grade patients 14 (73.68%) had high level of C-reactive proteins. Moreover hospital stay was also more among the patients having high pre-operative levels of C-reactive proteins (CRPs).Conclusions: The prognosis for patients with preoperative serum elevation of CRP was significantly more unfavourable than that for patients without serum CRP elevation.

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Preoperative elevation of serum C‐reactive protein as an indicator of poor prognosis for early‐stage esophageal squamous cell carcinoma

Cited by 17 publications

References 15 publications

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal Carcinoma

Prognostic role of serum C-reactive protein in carcinoma oesophagus

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