Preoperative dysphagia risk in community‐dwelling adults aged ≥50 years: Prevalence and risk factors

Canick, Julia; Campbell, James C.; Jones, Hilary; Leiman, David A.; Raman, Sudha R.; Starr, Kathryn

doi:10.1002/ncp.10889

Cited by 3 publications

(1 citation statement)

References 55 publications

(154 reference statements)

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“…In this case, dysphagia was subjectively classified by self-report and obtaining objective evidence of swallowing dysfunction was not possible. However, patients with normal swallowing on objective testing with self-reported dysphagia still demonstrate signs and symptoms of aspiration, reduced dietary intake, and reduced activity (Canick et al, 2022; Dewan et al, 2021). Thus, self-reported dysphagia and its association with FI and being homebound have substantial implications for the health of older adults that will contribute to future research.…”

Section: Discussionmentioning

confidence: 99%

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound

et al. 2023

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Objective: Our aim was to evaluate relationships between swallowing difficulty (dysphagia) and social determinants of health (SDOH) in older adults ≥65 years. Method: Cross-sectional analyses were performed in community-dwelling Medicare beneficiaries from the National Health & Aging Trends Study (NHATS). The primary exposure was self-reported difficulty chewing/swallowing in the prior month. Dependent measures included a variety of SDOH outcomes (e.g., food insecurity [FI]). Weighted logistic regression models were estimated to determine associations between dysphagia and SDOH outcomes. Results: Of 4041 participants, 428 (10.6%) self-reported dysphagia. In the adjusted model, dysphagia was associated with significantly increased odds for FI (odds ratio [OR] = 1.48, 95% confidence interval [CI] = 1.06, 2.07, p = .023) and being homebound (OR = 1.32, 95% CI = 1.13, 1.55, p= < .001). Discussion: Older adults with dysphagia had increased odds of FI and being homebound. These associations have implications for health-promoting interventions at the individual and policy levels in older adults.

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Section: Discussionmentioning

confidence: 99%

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound

et al. 2023

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Self-Reported Dysphagia and Psychosocial Health Among Community-Dwelling Older Adults: Results of a National Study

et al. 2023

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Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China

Li,

Wei

et al. 2024

BMC Cancer

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Background While there is an understanding of the association between the expression of Porphyromonas gingivalis (P. gingivalis) and prognosis of oral squamous cell carcinoma (OSCC), significance specially to address the relevance between different immunohistochemical intensities of P. gingivalis and tumor-associated macrophages (TAMs) in OSCC tissue and related clinicopathologic characteristics has not been well investigated. The present study aimed to investigate the pathological features related to M2-TAM in P. gingivalis-infected OSCC and ascertain its clinical relevance with patients’ prognosis. Methods A prospective cohort study was designed to comparatively analyze 200 patients from June 2008 to June 2020. Bioinformatics analyses were implemented to identify DOK3 as a key molecule and to appraise immunocyte infiltration using Gene Expression Omnibus and The Cancer Genome Atlas databases. Immunohistochemical evaluation was performed to analyze the association between the expression levels of P. gingivalis, DOK3, and M2-TAM and clinicopathological variables using Fisher’s exact test or Pearson’s chi-square test. Cox analysis was used to calculate hazard ratios (HR) with corresponding 95% confidence interval (CI) for various clinicopathological features. The Kaplan–Meier approach and log-rank test were used to plot the survival curves. Results The expression level of P. gingivalis was positively associated with DOK3 and M2-TAMs expression level (P < 0.001). Parameters, including body mass index, clinical stage, recurrence, tumor differentiation, and P. gingivalis, DOK3, and M2-TAM immunoexpression levels, affected the prognosis of patients with OSCC (all P < 0.05). In addition, P. gingivalis (HR = 1.674, 95%CI 1.216–4.142, P = 0.012), DOK3 (HR = 1.881, 95%CI 1.433–3.457, P = 0.042), and M2-TAM (HR = 1.649, 95%CI 0.824–3.082, P = 0.034) were significantly associated with the 10-year cumulative survival rate. Conclusions Elevated expression of P. gingivalis and DOK3 indicates M2-TAM infiltration and unfavorable prognosis of OSCC, and could be considered as three novel independent risk factors for predicting the prognosis of OSCC.

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Preoperative dysphagia risk in community‐dwelling adults aged ≥50 years: Prevalence and risk factors

Cited by 3 publications

References 55 publications

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound

Dysphagia in Older Adults is Associated With Food Insecurity and Being Homebound

Self-Reported Dysphagia and Psychosocial Health Among Community-Dwelling Older Adults: Results of a National Study

Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China

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