Preoperative differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and non-NIFTP

Hahn, Soo Yeon; Shin, Jung Hee; Lim, Hyun; Jung, So Lyung; Oh, Young Lyun; Choi, In Ho; Jung, Chan Kwon

doi:10.1111/cen.13263

Cited by 78 publications

(92 citation statements)

References 39 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…US evaluation is pivotal in determining the next step of FV PTC management. In a previous study, central nodal metastasis was identified in only one of 34 NIFTP cases (2.9%), none of which exhibited distant metastasis or recurrence [44,45]. Infiltrative FV PTCs are not overlooked when the current system for detecting thyroid nodules based on US features is used.…”

Section: Favorable Variantsmentioning

confidence: 98%

Ultrasonographic imaging of papillary thyroid carcinoma variants

Shin

2017

Ultrasonography

Self Cite

View full text Add to dashboard Cite

Ultrasonography (US) is routinely used to evaluate thyroid nodules. The US features of papillary thyroid carcinoma (PTC), the most common thyroid malignancy, include hypoechogenicity, spiculated/microlobulated margins, microcalcifications, and a nonparallel orientation. However, many PTC variants have been identified, some of which differ from the classic type of PTC in terms of biological behavior and clinical outcomes. This review describes the US features and clinical implications of the variants of PTC. With the introduction of active surveillance replacing immediate biopsy or surgical treatment of indolent, small PTCs, an understanding of the US characteristics of PTC variants will facilitate the individualized management of patients with PTC.

show abstract

Section: Favorable Variantsmentioning

confidence: 98%

Ultrasonographic imaging of papillary thyroid carcinoma variants

Shin

2017

Ultrasonography

Self Cite

View full text Add to dashboard Cite

show abstract

“…These studies will also allow a reevaluation of the reproducibility and robustness of the diagnostic criteria for NIFTP. This need is highlighted by 2 recent studies reporting single cases diagnosed as NIFTP with regional lymph node metastasis 21, 23. The NIFTP diagnostic errors may occur in both follicular and papillary lineage directions.…”

Section: Introductionmentioning

confidence: 99%

AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State‐of‐the‐art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features

et al. 2018

View full text Add to dashboard Cite

The newly introduced pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) will result in less bilateral thyroid surgery as well as deescalation in T4 suppressive and radioactive iodine treatment. Although, NIFTP is a nonmalignant lesion that has nuclear features of some papillary malignancies, the challenge for the surgeon is to identify a lesion as possibly NIFTP before the pathologic diagnosis. NIFTP, due to its reduction of overall rates of malignancy, will result in the initial surgical pendulum swinging toward lobectomy instead of initial total thyroidectomy. This American Head and Neck Society endocrine section consensus statement is intended to inform preoperative evaluation to attempt to identify those patients whose final pathology report may ultimately harbor NIFTP and can be offered a conservative surgical plan to assist in cost‐effective, optimal management of patients with NIFTP.

show abstract

“…Ultrasound [16][17][18] and cytologic studies [19][20][21][22][23][24] useful in the differentiation of NIFTP from PTC are summarized in Table I.…”

mentioning

confidence: 99%

Sonographic and cytologic differences of NIFTP from infiltrative or invasive encapsulated follicular variant of papillary thyroid carcinoma

Yang

Fried

Scognamiglio

2017

Diagnostic Cytopathology

View full text Add to dashboard Cite

We reclassified 179 cases of the follicular variant (FV) of papillary thyroid carcinoma (PTC) into 72 (40.2%) noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 37 (20.7%) encapsulated FVPTC with invasion (EFVPTC), and 70 (39.1%) infiltrative FVPTC (IFVPTC) without a capsule. In the NIFTP group, 5.6% cytology were hypercellular and the remainder low to moderate cellularity. PTC nuclei were absent in 18%, focally present in 37.5%, and diffusely present in 44.4%. In the EFVPTC group, 8.1% cytology were hypercellular and the reminder low to moderate cellularity. PTC nuclei were absent in 24.3%, focally present in 29.7% and diffusely present in 45.9%. In IFVPTC group, 24.3% cytology were hypercellular and the reminder low to moderate cellularity. PTC nuclei were diffusely present in 88.6% and focally present in 11.4%. The ultrasound findings for NIFTP and minimally invasive EFVPTC typically demonstrated a circumscribed oval/round nodule with a hypoechoic rim, and the Doppler was mostly hypervascular. The ultrasound findings for overtly invasive EFVPTC typically showed a round/oval nodule with irregular margins and the Doppler was mostly hypervascular. The ultrasound findings for IFVPTC group showed at least one of the malignant gray-scale features: markedly hypoechoic, taller-than-wide, microcalcifications or blurred margins. The Doppler in this group was mostly avascular. An algorithm is proposed to triage thyroid FNA based on different scenarios of the sampled cells, interpreted in the context of ultrasound features with histology outcomes. Five composite ultrasound-cytology-histology figures illustrate NIFTP, IFVPTC, and IFVPTC with intratumoral fibrosis, microfollicular EFVPTC and normofollicular EFVPTC. Diagn. Cytopathol. 2017;45:533-541. © 2017 Wiley Periodicals, Inc.

show abstract

Preoperative differentiation between noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and non-NIFTP

Abstract: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features lacks malignant US features and is better triaged using US-CNB than using US-FNA to facilitate the surgical management. US evaluation is pivotal in determining the next step of FVPTC management.

Cited by 78 publications

References 39 publications

Ultrasonographic imaging of papillary thyroid carcinoma variants

Ultrasonographic imaging of papillary thyroid carcinoma variants

AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State‐of‐the‐art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features

Sonographic and cytologic differences of NIFTP from infiltrative or invasive encapsulated follicular variant of papillary thyroid carcinoma

Contact Info

Product

Resources

About