Preoperative diagnosis of tubular adenoma of breast - 10 years of experience

Abstract

Background:Tubular adenomas are rare benign neoplasms of female breast affecting women, predominantly of child-bearing age group. Definitive diagnosis of this tumor is usually achieved after histopathological study. Clinical, radiological, and even cytological features are often insufficient for accurate diagnosis.Aim:The aim of the present study was planned to analyze clinical and radiological features of histologically confirmed cases of tubular adenoma of breast to find out a clue for accurate preoperative cytological diagnosis. Materials and Methods: In our 10-year research program, all histologically confirmed tubular adenoma cases of breast were studied. Clinico-radio-cytological features, if available, were analyzed and tabulated.Results:Thirty-three cases of tubular adenoma of breast were studied. Radiological and cytological assessments are available for 12 and 26 cases, respectively. Tubular adenoma could be diagnosed in only two cases (7.7%) by cytological assessment, but in none by radiological assessment.Conclusions:Clinico-cyto-radiological assessment could identify the benign nature of the tumors in most cases, but final confirmation was possible only after histopathological study.

Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases

“… 3 , 4 The preoperative diagnosis of tubular adenoma is quite impossible, only the histology can achieve a definitive correct diagnosis. 5 The cytologic examination is not reliable as it often fails to diagnose correctly the tubular adenoma. 5 , 6 Biopsies or lumpectomy provide a sufficient tumoral tissue to allow a correct diagnosis.…”

“… 5 The cytologic examination is not reliable as it often fails to diagnose correctly the tubular adenoma. 5 , 6 Biopsies or lumpectomy provide a sufficient tumoral tissue to allow a correct diagnosis. The classical histologic aspect of tubular adenoma is a proliferation of packed tubular structures within a small amount of fibrous stroma.…”

“…Little is known about tubular adenoma as in the current literature only some case reports or small series are described. 1 , 2 , 5 , 6 Our aim is to provide clinicopathologic features of breast tubular adenoma through a retrospective study.…”

Tubular adenoma of the breast: radiological and ultrasound findings

“…Although four cases of malignant transformation of tubular adenoma have been reported in the literature, studies indicate that there is no high risk for carcinoma ( 1 ) . Tubular adenoma accounts for 0.13-1.7% of all benign neoplasms of the breast ( 3 ) . Although the size of the tumor ranges from 1 cm to 7.5 cm, it rarely exceeds 5 cm ( 4 ) .…”

“…Sengupta et al. ( 3 ) , analyzing 32 confirmed cases of tubular adenoma, concluded that, although radiological and cytological studies can distinguish between benign and malignant lesions, the final diagnosis depends on the histopathology ( 3 ) .…”