Preoperative diagnosis and management of inherited bleeding disorders in female adolescents and adults

Abstract

Although inherited bleeding disorders (IBDs) affect both females and males, this review of the preoperative diagnosis and management of IBDs focuses on genetic and gynecologic screening, diagnosis and management of affected and carrier females. A PubMed literature search was conducted, and the peer-reviewed literature on IBDs was evaluated and summarized. Best-practice considerations for screening, diagnosis and management of IBDs in female adolescents and adults, with GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) evidence level and ranking of recommendation strength, are presented. Health care providers need to increase their recognition of and support for female adolescents and adults with IBDs. Improved access to counselling, screening, testing and hemostatic management is also required. Patients should be educated and encouraged to report abnormal bleeding symptoms to their health care provider when they have a concern. It is hoped that this review of preoperative IBD diagnosis and management will enhance access to women-centred care to increase patients’ understanding of IBDs and decrease their risk of IBD-related morbidity and mortality.

Impact of Replacement Therapy on Pregnancy Outcomes in Hemophilia Carriers: A Historical Cohort Study in Saudi Arabia

“…Pregnancy in hemophilia carriers poses unique challenges due to the increased risk of bleeding, which can exacerbate the underlying condition [17]. While hemophilia primarily affects males, female carriers can experience varying degrees of bleeding symptoms, which may intensify during pregnancy due to hormonal changes and increased blood volume [18,19]. The most common complication is an enhanced risk of hemorrhage during delivery, which necessitates careful planning and monitoring.…”