Preoperative depressive symptoms are not predictors of postoperative seizure control in patients with mesial temporal lobe epilepsy and hippocampal sclerosis

Lackmayer, Katharina; Lehner-Baumgartner, Eva; Pirker, Susanne; Czech, Thomas; Baumgartner, Christoph

doi:10.1016/j.yebeh.2012.06.022

Cited by 44 publications

(12 citation statements)

References 34 publications

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“…The results suggest that common pathogenetic mechanisms are operant in psychiatric disorders and epilepsy. Unlike some smaller studies based only on patients with MTS, 22,23 we saw negative effects of psychiatric histories on seizure outcome regardless of the morphology of the resected tissue. More than two thirds of patients in our cohort received a psychiatric diagnosis.…”

Section: Discussioncontrasting

confidence: 96%

“…In fact, the prognostic value of depression with respect to seizure outcome is not clear. One study reported that low preoperative depression scores were associated with seizure freedom after surgery, whereas another found no correlation between depressive symptoms and postoperative outcome …”

Section: Discussionmentioning

confidence: 99%

“…11 However, one study failed to find a global association between psychiatric diagnosis and unfavorable surgical outcome, although it did report an association between failure to achieve Engel class IA and presence of anxiety or personality disorders. 21 Two studies (both n < 80), exclusively on MTS patients, failed to detect a significant correlation between seizure outcome and depressive symptoms 22 or psychiatric disorders. 23 We analyzed presurgical psychiatric diagnoses and 2-year postoperative seizure outcome in a series of >400 patients who underwent temporal resection.…”

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confidence: 99%

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Psychiatric lifetime diagnoses are associated with a reduced chance of seizure freedom after temporal lobe surgery

et al. 2017

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Patients with and without psychiatric comorbidities can benefit from temporal lobe epilepsy surgery; however, psychiatric comorbidities are negatively associated with postoperative seizure-freedom rates. Surgical outcome is related to the type and extent of preoperative psychiatric morbidity, which underscores the prognostic value of presurgical psychiatric evaluation. The data support the argument that there are common pathogenetic mechanisms underlying both epilepsy and psychiatric conditions.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Psychiatric lifetime diagnoses are associated with a reduced chance of seizure freedom after temporal lobe surgery

et al. 2017

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“…A history of psychiatric disorder, in particular depression, was not associated with a poorer surgical outcome in patients with MTS. Others [38] also showed that depressive symptoms, identified by the BDI, do not seem to have a predictive value for postoperative seizure outcome in this highly selected patient population with MTS.…”

Section: Discussionmentioning

confidence: 99%

Severe hippocampal atrophy is not associated with depression in temporal lobe epilepsy

Hečimović¹,

Santos²,

Price³

et al. 2014

Epilepsy & Behavior

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Depression in temporal lobe epilepsy (TLE) is common, is a strong predictor of subjective disability, and may have unique pathophysiological characteristics. Previous studies showed that reduced hippocampal volume is associated with significant depressive symptoms in TLE patients. We utilized regions of interest analysis of high-resolution brain MRI and a reliable and valid measure of depressive symptoms to evaluate 28 consecutive adult subjects with video/EEG confirmed TLE. Regions of interest were based on prior human and animal studies of mood and behavioral dysfunction. Forty-three percent of the entire group had significant symptoms of depression, defined by a Beck Depression Inventory (BDI) score of greater than 15. Total hippocampal volumes were significantly smaller in the group with BDI< 15, (p< 0.007). None of the subjects in the quartile with the smallest left hippocampal volume had a BDI score greater than 15, compared to 57% of the subjects in the upper three quartiles (p< 0.008). No other limbic brain structures that we assessed: amygdala, subcallosal gyrus, subgenual gyrus, gyrus rectus, or total cerebral volume, were associated with depressive symptoms. Adequate hippocampal integrity may be necessary to maintain depression symptoms in mesial temporal lobe epilepsy. This finding also supports the possibility of a unique mechanism for depression in mesial temporal lobe epilepsy, such as hyerexcitable neuronal influence on the limbic network.

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“…Psychiatric disorders and cognitive impairment in patients with epilepsy thus may be considered to reflect the degree of brain dysfunction and to be predictive for the epilepsy outcome. In light of these findings, several studies tried to use comorbidities as biomarkers for epilepsy outcome but with inconsistent findings (Lackmayer et al, 2013;Talos et al, 2012).…”

Section: Selected Referencesmentioning

confidence: 99%

Untangling the pathomechanisms of temporal lobe epilepsy—The promise of epileptic biomarkers and novel therapeutic approaches

Szilágyi¹,

Száva²,

Metz³

et al. 2014

Brain Research Bulletin

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Preoperative depressive symptoms are not predictors of postoperative seizure control in patients with mesial temporal lobe epilepsy and hippocampal sclerosis

Cited by 44 publications

References 34 publications

Psychiatric lifetime diagnoses are associated with a reduced chance of seizure freedom after temporal lobe surgery

Psychiatric lifetime diagnoses are associated with a reduced chance of seizure freedom after temporal lobe surgery

Severe hippocampal atrophy is not associated with depression in temporal lobe epilepsy

Untangling the pathomechanisms of temporal lobe epilepsy—The promise of epileptic biomarkers and novel therapeutic approaches

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