Preoperative Cytodiagnosis of Pleomorphic Adenoma with Extensive Lipometaplasia

Siddaraju, Neelaiah; Singh, Neha; Muniraj, Femela; Jothilingam, Prabhavati; Kumar, Surendra; Basu, Debdatta; Saxena, Sunil

doi:10.1159/000325353

Cited by 9 publications

(9 citation statements)

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“…Although scattered, isolated adipocytes might be encountered in classical pleomorphic adenomas more commonly if thoroughly searched for, pleomorphic adenomas and myoepitheliomas with extensive lipometaplasia comprising C20 % of the tumor is exceedingly uncommon with less than 15 reported cases in the English literature to date (10 pleomorphic adenomas and 5 myoepitheliomas) [3][4][5][6][7][8][9][10]. Approximately 80 % of tumors involved major salivary glands (11/12 in the parotid) with only three cases in minor glands.…”

Section: Pleomorphic Adenoma and Myoepithelioma With Lipometaplasiamentioning

confidence: 99%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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Fat-containing tumors of the salivary glands are uncommon. Their wide histological spectrum varies from pure lipomatous neoplasms similar to their cutaneous and soft tissue counterparts to mixed lipoepithelial lesions specific to the salivary glands. With few exceptions, these uncommon lesions affect mainly the elderly, with a mean age at presentation of C50 years and show a predilection for males. A few cases occur in childhood; some of them represent congenital lesions. In decreasing order of frequency, ordinary (soft-tissue type) lipoma, oncocytic lipoadenoma, non-oncocytic sialolipoma, and pleomorphic adenoma/myoepithelioma with extensive lipometaplasia are the main variants of fat containing tumors encountered in the salivary glands. While pleomorphic adenoma/myoepithelioma with lipometaplasia behave in the same way as their non-fat-containing counterparts, other lipomatous salivary gland tumors listed above are cured with simple excision and do not carry a risk of recurrence. Other lipoma variants (spindle cell lipoma, osteolipoma, fibrolipoma, angiolipoma, pleomorphic lipoma, lipoblastoma and hibernoma) are exceptionally rare in the salivary gland. Atypical lipomatous tumors/liposarcoma have been only rarely reported in the salivary gland and they behave in a similar fashion to their soft-tissue counterparts. Diffuse lipomatosis and lobular fatty atrophy are the two tumor-like lesions that might closely mimic sialolipoma, particularly in limited biopsy material without knowledge of the gross findings. This review summarizes the clinicopathological features of the main types of salivary fat-containing lesions and discusses their differential diagnoses.

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Section: Pleomorphic Adenoma and Myoepithelioma With Lipometaplasiamentioning

confidence: 99%

Fat-Containing Salivary Gland Tumors: A Review

Agaimy

2013

Head and Neck Pathol

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“…Of these, FNA practice was reported in two cases and cytopathological image was available in only one case. [35] In our case, radiological findings were not available and FNA was the first-step diagnostic method.…”

Section: Discussionmentioning

confidence: 81%

“…The less frequent localizations were minor salivary glands (4/11, 33.3%) and submandibular gland in one case (8.4%). [12345] Three LPA cases, located out of the salivary glands, were also reported in the literature; external auditory canal and skin of the scalp and breast were the sites in these cases. These cases were seen in elderly (65-74 yrs.).…”

Section: Discussionmentioning

confidence: 99%

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Lipomatous pleomorphic adenoma in the hard palate: Report of a rare case with cyto-histo correlation and review

Musayev

Önal

Hasanov

et al. 2014

J Cytol

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Pleomorphic adenoma is the most common benign tumor of the salivary glands. They are usually composed of epithelial/myoepithelial cells and chondromyxoid stroma. Extensive lipomatous differentiation is very rare. We report a case of lipomatous pleomorphic adenoma (LPA) that presented with a mass in the hard palate of a 32-year-old woman. The fine-needle aspiration cytology material was reported as benign cytology consistent with adenoma with major adipocytic component. Histopathological examination of the excision material displayed that more than 90% of the tumor was adipocytic in texture, containing scant epithelial and myoepithelial cells and chondromyxoid stromal fragments. Preoperative cytodiagnosis of lipomatous pleomorphic adenoma on FNA is based on cytomorphology intimately associated pleomorphic adenomatous and lipomatous tissue elements. LPA should be on the mental list of the (cyto)pathologist in differential diagnosis of lipomatous tumors or non-tumorous lipomatosis or carcinoma invasion in the adipose tissue of the minor salivary gland of the hard palate.

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“…The case presented by Nepka et al, 3 from Greece, details how morphologic changes suggestive of peripheral nerve sheath tumor supported by immunocytochemical studies are helpful in the diagnosis of this uncommon tumor. Siddaraju et al 4 from India describe a rare case of pleomorphic adenoma with extensive lipometaplasia, Daneshbod and Khademi 5,6 from Iran describe a rare case of hydatid disease of the submandibular gland and also an intraductal papilloma of the parotid gland. Ohta et al 7 from Japan report a case of mature cystic teratoma arising in the parotid gland, and primary malignant melanoma arising in the parotid gland, a very rare lesion, is reported by Bangerter 8 from Germany.…”

Section: Editorialmentioning

confidence: 99%

Fine Needle Aspiration of Salivary Glands

Bibbo¹

2009

Acta Cytologica

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Preoperative Cytodiagnosis of Pleomorphic Adenoma with Extensive Lipometaplasia

Cited by 9 publications

References 10 publications

Fat-Containing Salivary Gland Tumors: A Review

Fat-Containing Salivary Gland Tumors: A Review

Lipomatous pleomorphic adenoma in the hard palate: Report of a rare case with cyto-histo correlation and review

Fine Needle Aspiration of Salivary Glands

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