Preoperative Controlling Nutritional Status (CONUT) score predicts short-term outcomes of patients with gastric cancer after laparoscopy-assisted radical gastrectomy

Abstract

Background An emerging prediction tool, the Controlling Nutritional Status (CONUT) score, has shown good assessment ability of postoperative outcomes in cancer patients. This study evaluated the role of the preoperative CONUT score regarding the short-term outcomes of gastric cancer (GC) after laparoscopic gastrectomy. Methods Three hundred and nine GC patients undergoing laparoscopic gastrectomy from January 2016 to June 2019 were analysed, retrospectively. The patients were divided into two groups according to the CONUT optimal cut-off value. Clinical characteristics and postoperative complications in the two groups were analysed and evaluated. Risk factors for complications were identified by univariate and multivariate analyses. Results A total of 309 patients underwent laparoscopic gastrectomy; 91 (29.4%) patients experienced postoperative complications. The preoperative CONUT score showed a good predictive ability for postoperative complications (area under the curve (AUC) = 0.718, Youden index = 0.343) compared with other indices, with an optimal cut-off value of 2.5. Patients with high CONUT score had a significantly higher incidence of overall complications (P < 0.001). Age, haemoglobin, C-reactive protein, red blood cell levels, CONUT scores, surgical procedure type, T1, T4, N0 and N3 pathological TNM classification, and pathological stages of I and III were associated with postoperative complications (P < 0.05). Furthermore, the preoperative CONUT score was identified as an independent risk predictor of postoperative complications (P = 0.012; OR = 2.433; 95% CI, 1.218-4.862) after multivariate analysis. Conclusions The preoperative CONUT score is a practical nutritional assessment for predicting short-term outcomes in GC patients after laparoscopy-assisted gastrectomy.

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

“…As a member of the inflammatory cell family, LYM is involved in altering the tumor microenvironment. Patients with low LYM levels were reported to have a worse prognosis than those with high LYM levels (22)(23)(24). In this study, we further explored the factors that affect the development of HIV infectionassociated lymphoma.…”

Value of the Controlling Nutritional Status score in predicting the prognosis of patients with lung cancer: A multicenter, retrospective study

“…The CONUT score can also be used as a prognostic predictor for many other solid tumors. Studies have found that the CONUT score is a strong independent predictor of postoperative complications and longterm prognosis in colorectal cancer, 13,[22][23][24] cholangiocarcinoma, 25,26 kidney cancer, 27 esophageal cancer, 28 gastric cancer, 12,29 pancreatic cancer, 30 and liver cancer. 31,32 We established a nomogram based on the CONUT score for accurate prediction of the prognosis of patients with lung cancer.…”

Controlling Nutritional Status (CONUT) as a Novel Postoperative Prognostic Marker in Breast Cancer Patients: A Retrospective Study

“…BC cancer prognosis appears to be closely related to the degree of systemic inflammation and nutritional status [29,30]. Although the use of CONUT was previously confined to assessing nutritional status only, more and more evidence has highlighted its ability to predict cancer patient survival [31][32][33]. The various components of the CONUT score-TLC, ALB, and TC, reflect impaired immune defenses, protein reserves, and caloric depletion, respectively.…”