Preoperative Colonic Lesion Localization with Charcoal Nanoparticle Tattooing for Laparoscopic Colorectal Surgery

Abstract

The efficiency and safety of charcoal nanoparticle tattooing in localizing unpalpable colonic small lesions for later laparoscopy is described. Twenty six patients were enrolled for this prospective study. Tumor sites were localized with charcoal nanoparticles during colonoscopy for later laparoscopic colorectal operations. In all patients, the entire colon was examined preoperatively by colonoscopy and 0.5 ml (5 mg) of charcoal nanoparticle was injected submucosally near lesions or polypectomy sites. During laparoscopic colorectal operations for these biopsy-proven tumors, tumors were easily identified. The mean resection margin was 3.13 +/- 2.01 cm. The mean length of resected intestinal segment was 12.69 +/- 4.39 cm. No tumor was found at the resection line as indicated by postoperative pathological examination. Most importantly, no wrong segment was resected. Thus we show that easy identification of tumor can be achieved by preoperative tattooing with charcoal nanoparticles. Further studies regarding the long-term tattooing of tumor with charcoal nanoparticles are warranted.

Application of nano-carbon and titanium clip combined labeling in robot-assisted laparoscopic transverse colon cancer surgery

“…Intraoperative colonoscopy can also be used for positioning, but it is a more complex method that requires experienced endoscopists and speci c equipment in the operating room, which can increase the time of surgery and increase the risk of anesthesia and the probability of infection [7]. In addition, colonoscopy will in ate the intestines, increasing the di culty of surgery [13]. In recent years, the most common method of positioning has been to inject a stain into the intestinal wall.…”

“…However, the above methods have their own shortcomings and limitations, such as radioactivity, inaccurate positioning, easy removal of titanium clips, and dispersion of stains [10,11,12]. In recent years, with the development of nanotechnology, carbon nanoparticles have been applied to tumor markers, such as colorectal cancer [13], breast cancer [14]. The injected carbon nanoparticle suspension contains nanometer carbon particles with an average diameter of 150 nm.…”

Application of carbon nanoparticles to mark locations for re-inspection after colonic polypectomy

“…Recently, carbon nanoparticles have been used as lymph node tracers in gastric cancer and colorectal cancer patients. A study showed that preoperative colon tattooing with carbon nanoparticles marked gastric features for 14 days [9], which was longer than other common dyestuffs.…”

Successful closure of gastrocolic fistula using preoperative localization with charcoal nanoparticles tattooing

“…In our previous studies, we have successfully used charcoal nanoparticles tattooing for preoperative localization during colon and breast cancer surgery and have proved its effectiveness and security (4,5). Charcoal nanoparticles have also been reported to be used for Delphian lymph node tracking in thyroid surgery.…”