Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer

Abstract

* Neoplasm Recurrence, Local [prevention & control]; Randomized Controlled Trials as Topic; Rectal Neoplasms [ * drug therapy; pathology; * radiotherapy; surgery] 20 Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer (Review)

Impact of Duration of Neoadjuvant Radiation on Rectal Cancer Survival: A Real World Multi-center Retrospective Cohort Study

“…These findings are in line with a previously published Cochrane review. 17 In turn, complete pathologic response was associated with better OS in the current analysis; this is also consistent with previously published studies demonstrating improved outcomes with complete pathologic response. [18][19][20] Although pathologic complete response occurred exclusively in patients receiving LC therapy in our study, this did not consistently translate to better overall outcomes for the LC group.…”

Impact of Duration of Neoadjuvant Radiation on Rectal Cancer Survival: A Real World Multi-center Retrospective Cohort Study

“…These findings are in line with a previously published Cochrane review. 17 In turn, complete pathologic response was associated with better OS in the current analysis; this is also consistent with previously published studies demonstrating improved outcomes with complete pathologic response. [18][19][20] Although pathologic complete response occurred exclusively in patients receiving LC therapy in our study, this did not consistently translate to better overall outcomes for the LC group.…”

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…LCRT was associated with higher rates of polymerase chain reaction (pCR; 7.9% vs 4.3%) and lower rates of positive CRM (5.2% vs 8.3%) compared with SCRT. The decreased pCR rate with SCRT is consistent with a previously published systematic review 17 and randomized comparisons between SCRT and LCR. 9 , 10 Although the correlation between pathological complete response and better survival outcomes has been shown, 18 , 19 , 21 randomized studies have shown no differences in survival between patients receiving SCRT and LCRT.…”

Identification of Predictors of Recurrence in Patients with Lower Rectal Cancer Undergoing Neoadjuvant Chemotherapy: A Direct Comparison of Short-Course and Long-Course Chemoradiotherapy

“…Accumulating evidence reveals the clinical impacts of these therapies for surgical and oncological outcomes in patients with advanced rectal cancer. The pathological response in surgical specimens for preoperative RT was superior in long-course RT compared with short-course RT; however, previous studies revealed no difference between these two therapies in terms of survival and local recurrence [2,6,7].…”

Impact of Duration of Neoadjuvant Radiation on Rectal Cancer Survival: A Real World Multi-center Retrospective Cohort Study

“…These findings are in line with a previously published Cochrane review. 17 In turn, complete pathologic response was associated with better OS in the current analysis; this is also consistent with previously published studies demonstrating improved outcomes with complete pathologic response. [18][19][20] Although pathologic complete response occurred exclusively in patients receiving LC therapy in our study, this did not consistently translate to better overall outcomes for the LC group.…”

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…LCRT was associated with higher rates of polymerase chain reaction (pCR; 7.9% vs 4.3%) and lower rates of positive CRM (5.2% vs 8.3%) compared with SCRT. The decreased pCR rate with SCRT is consistent with a previously published systematic review 17 and randomized comparisons between SCRT and LCR. 9 , 10 Although the correlation between pathological complete response and better survival outcomes has been shown, 18 , 19 , 21 randomized studies have shown no differences in survival between patients receiving SCRT and LCRT.…”

Identification of Predictors of Recurrence in Patients with Lower Rectal Cancer Undergoing Neoadjuvant Chemotherapy: A Direct Comparison of Short-Course and Long-Course Chemoradiotherapy

“…Accumulating evidence reveals the clinical impacts of these therapies for surgical and oncological outcomes in patients with advanced rectal cancer. The pathological response in surgical specimens for preoperative RT was superior in long-course RT compared with short-course RT; however, previous studies revealed no difference between these two therapies in terms of survival and local recurrence [2,6,7].…”

Impact of Duration of Neoadjuvant Radiation on Rectal Cancer Survival: A Real World Multi-center Retrospective Cohort Study

“…These findings are in line with a previously published Cochrane review. 17 In turn, complete pathologic response was associated with better OS in the current analysis; this is also consistent with previously published studies demonstrating improved outcomes with complete pathologic response. [18][19][20] Although pathologic complete response occurred exclusively in patients receiving LC therapy in our study, this did not consistently translate to better overall outcomes for the LC group.…”

Utilization of short-course radiation therapy for patients with nonmetastatic rectal adenocarcinoma in the United States

“…LCRT was associated with higher rates of polymerase chain reaction (pCR; 7.9% vs 4.3%) and lower rates of positive CRM (5.2% vs 8.3%) compared with SCRT. The decreased pCR rate with SCRT is consistent with a previously published systematic review 17 and randomized comparisons between SCRT and LCR. 9 , 10 Although the correlation between pathological complete response and better survival outcomes has been shown, 18 , 19 , 21 randomized studies have shown no differences in survival between patients receiving SCRT and LCRT.…”

Identification of Predictors of Recurrence in Patients with Lower Rectal Cancer Undergoing Neoadjuvant Chemotherapy: A Direct Comparison of Short-Course and Long-Course Chemoradiotherapy

“…Accumulating evidence reveals the clinical impacts of these therapies for surgical and oncological outcomes in patients with advanced rectal cancer. The pathological response in surgical specimens for preoperative RT was superior in long-course RT compared with short-course RT; however, previous studies revealed no difference between these two therapies in terms of survival and local recurrence [2,6,7].…”