“…42,49 Only a minority of studies had specific cardiac exclusion criteria. 24,30,34,38,40,43,49 Most of the included studies were observational using either cross-sectional 22,[24][25][26]28,34,40,41,45,46,48 or retrospective cohort designs (Table 1). 27,30,32,33,37,38,[42][43][44]47,49 Of those with an intervention, 23,29,31,35,36,39 none was a randomized controlled trials although one was a nonrandomized controlled trial (Supporting Information: Table 8).…”