Preoperative C-reactive protein levels to predict early and late mortalities after coronary artery bypass surgery: Eight years of follow-up

Abstract

Preoperative C-reactive protein levels can be used in risk stratification in coronary artery bypass grafting surgery. A C-reactive protein level greater than 10 mg/L is a risk factor for early mortality, whereas a level greater than 5 mg/L is a risk factor for late mortality.

suPAR is associated with risk of future acute surgery and post-operative mortality in acutely admitted medical patients

“…There is a limited amount of research that has used acute surgery as an outcome measurement, and the use of biomarkers for risk prediction in surgery is generally directed towards predicting post-operative outcomes, such as morbidity and mortality [ 24 , 25 ]. A British study found associations between increasing CRP levels during admittance and the risk of undergoing acute surgery in patients presenting with acute renal colic.…”

Impact of Preoperative C-Reactive Protein on Midterm Outcomes after Off-Pump Coronary Artery Bypass Grafting

“…4,5 In cardiac surgery field, several investigators evaluated the impact of preoperative CRP level on postoperative outcomes. [6][7][8][9][10][11]14 Cappabianca et al 14 suggested a value of 0.5 mg/dL or greater as a predictor of in-hospital mortality, postoperative infection, and midterm mortality. They included 597 patients with all types of cardiac procedures including on-pump/off-pump coronary bypass surgery and valvular and aortic root surgery.…”

“…4,5 In coronary artery bypass grafting (CABG) field, increased preoperative CRP has been reported as an independent predictor of early and long-term mortality as well as early graft occlusion. [6][7][8][9][10][11] Most studies evaluating the relation between preoperative CRP and postoperative clinical outcomes focused on on-pump CABG. Conventional on-pump CABG using cardiopulmonary bypass (CPB) and cardiac arrest has diverse range of perioperative inflammatory reaction that may affect postoperative adverse outcomes.…”

Off‐Pump Coronary Artery Bypass Grafting: 30 Years of Debate

“…Inflammation has been proposed to have an important role in determining early postoperative complications (eg, low‐output syndrome, myocardial injury, and atrial fibrillation or stroke). Indeed, increased preoperative CRP (C‐reactive protein) levels are independently associated with early and late mortality in CABG patients 24. In other studies, preoperative levels of IL‐6, IL‐8, and MCP‐1 (monocyte chemoattractant protein 1) predict postoperative atrial fibrillation development in CABG patients 25.…”