Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery

Mazzeffi, Michael; Kassa, Woderyelesh; Gammie, James S.; Tanaka, Kenichi A.; Roman, Philip; Zhan, Min; Griffith, Bartley P.; Rock, Peter

doi:10.1097/sa.0000000000000219

Cited by 5 publications

(11 citation statements)

References 1 publication

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“…In a prospective observational study of 202 adult patients with ARDS, prehospital aspirin therapy was associated with a substantial reduction in overall intensive care unit mortality (OR: 0.38; 95% CI: 0.15-0.96) (13). While these studies do suggest possible protective effects of aspirin in ARDS, other studies have shown no significant association between prehospital aspirin use and the development of ARDS (78) nor any beneficial effect of aspirin in reducing the incidence of ARDS after elective surgery (66). Given the ongoing uncertainty about the potential utility of antiplatelet therapies in ARDS, a multicenter randomized control trial of aspirin for the prevention of ALI (LIPS-A) is currently underway (ClincalTrials.gov ID: NCT01504867) (54).…”

Section: Antiplatelet Therapies In the Prevention Of Lung Injurymentioning

confidence: 81%

Platelets in the pathogenesis of acute respiratory distress syndrome

Yadav

Kor

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

106

135

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Platelets have an emerging and incompletely understood role in a myriad of host immune responses, extending their role well beyond regulating thrombosis. Acute respiratory distress syndrome is a complex disease process characterized by a range of pathophysiologic processes including oxidative stress, lung deformation, inflammation, and intravascular coagulation. The objective of this review is to summarize existing knowledge on platelets and their putative role in the development and resolution of lung injury.

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Section: Antiplatelet Therapies In the Prevention Of Lung Injurymentioning

confidence: 81%

Platelets in the pathogenesis of acute respiratory distress syndrome

Yadav

Kor

2015

American Journal of Physiology-Lung Cellular and Molecular Phys

106

135

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“…Moreover, another prospective trial including patients with ARDS showed that prehospital administration of aspirin led to reduced intensive care unit mortality [133] . Nevertheless, there are several studies showing no significant effects of prehospital aspirin therapy on the incidence of ARDS [134,135] . In order to elucidate the effectiveness of aspirin on the prevention of ARDS, a multicenter randomized control trial was performed, which did not confirm a preventive role of aspirin in the development of ARDS in patients at risk [136] .…”

Section: The Role Of Platelets and Immune Cells In The Resolution Of mentioning

confidence: 99%

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

Frantzeskaki¹,

Armaganidis²,

Orfanos³

2016

Respiration

224

251

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Acute respiratory distress syndrome (ARDS) is defined as a syndrome of acute onset, with bilateral opacities on chest imaging and respiratory failure not caused by cardiac failure, leading to mild, moderate, or severe oxygenation impairment. The syndrome is most commonly a manifestation of sepsis-induced organ dysfunction, characterized by disruption of endothelial barrier integrity and diffuse lung damage. Imbalance between coagulation and inflammation is a predominant characteristic of ARDS, leading to extreme inflammatory response and diffuse fibrin deposition in vascular capillary bed and alveoli. Activated platelets, neutrophils, endothelial cells, neutrophil extracellular traps, microparticles, and coagulation proteases, participate in the complex process of immunothrombosis, which is a key event in ARDS pathophysiology. The present review is focused on the elucidation of immunothrombosis in ARDS and the potential therapeutic implications.

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“…1). [18][19][20][22][23][24][25] Three studies were prospective cohort investigations, 3 were retrospective cohort investigations, and one was a retrospective nested case-control study. These studies were performed in various sample sizes (ranging from 141 to 23,882 subjects), populations, and care settings ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…16,17 However, whether prehospital antiplatelet therapy elicits beneficial effects in patients with ARDS who are critically ill remains controversial. [18][19][20] Therefore, we performed a meta-analysis and provided an update on the scientific literature to explore the effect of pre-hospital antiplatelet drugs on the incidence of ARDS. Our key objectives were to determine if pre-hospital antiplatelet therapy is associated with decreased ARDS risk and ARDS-related mortality in subjects at high risk.…”

Section: Introductionmentioning

confidence: 99%

Effects of Pre-Hospital Antiplatelet Therapy on the Incidence of ARDS

et al. 2020

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BACKGROUND: Clinical observations on the potential of pre-hospital antiplatelet therapy in preventing ARDS have been inconsistent. To further the correlation between antiplatelet therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital antiplatelet therapy on subjects with ARDS. METHODS: A literature search in major data banks was performed. We included prospective and retrospective cohorts, case-control trials, and randomized controlled trials that compared the ARDS incidence in subjects with or without pre-hospital antiplatelet agents. RESULTS: Meta-analysis of 7 studies (a total of 30,291 subjects) showed significantly lower odds of ARDS in the pre-hospital antiplatelet therapy group compared with subjects with no pre-hospital antiplatelet therapy (odds ratio 0.68, 95% CI 0.56-0.83; P < .001). However, ARDS mortalities in the hospital and ICUs were not affected. CONCLUSIONS: These findings indicated that pre-hospital antiplatelet therapy was associated with a reduced rate of ARDS but had no effect on the mortality in the subjects at high risk.

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Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery

Cited by 5 publications

References 1 publication

Platelets in the pathogenesis of acute respiratory distress syndrome

Platelets in the pathogenesis of acute respiratory distress syndrome

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

Effects of Pre-Hospital Antiplatelet Therapy on the Incidence of ARDS

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