Preoperative Aspirin Does Not Increase Transfusion or Reoperation in Isolated Valve Surgery

Goldhammer, Jordan E.; Herman, Corey R.; Berguson, Mark; Torjman, Marc C.; Epstein, Richard H.; Sun, Jianyong

doi:10.1053/j.jvca.2017.05.011

Cited by 7 publications

(13 citation statements)

References 19 publications

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“…Pooling the results of both RCTs and observational studies, preoperative aspirin did not show any substantial difference in the rates of surgical re‐exploration due to bleeding (OR 1.02; 95%CI 0.86‐1.21; P = 0.79; I 2 = 0 %; P heterogeneity = 0.83) (Figure ). The evidence was derived from the analysis of 26 146 patients, of who 94.11% underwent an isolated CABG, 0.61% underwent CABG +/− concomitant heart valve surgery, and 4.5% underwent valve surgery.…”

Section: Resultsmentioning

confidence: 98%

“…A total of 3922 patients from 12 RCTs and 30 893 patients coming from 28 observational studies met our inclusion criteria and were included in the meta‐analysis. Characteristics of the studies are presented in Tables and .…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen observational studies reported 30‐day mortality with an aggregate of 27 944 patients. Pooling the results of the observational studies, preoperative aspirin showed a significant decrease in postoperative mortality by 32% (OR 0.68; 95%CI 0.55‐0.85; P = 0.0004; I 2 = 23%; P heterogeneity = 0.19) (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Pooling the results of both RCTs and observational studies, preoperative aspirin showed a significant decrease in postoperative mortality by 29% (OR 0.71; 95%CI 0.6‐0.84; P = 0.0001; I 2 = 7%; P heterogeneity = 0.36). A total of 31 306 patients have been pooled to assess 30‐day mortality of which 93.03% underwent CABG with or without heart valve surgery (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen observational studies reported PRBC transfusion rates. The analysis was based on the results from 18 392 patients.…”

Section: Resultsmentioning

confidence: 99%

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The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

et al. 2017

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Preoperative aspirin increases the risk for postoperative bleeding. However, this did not result in an increased need for chest re-exploration and did not increase the rates of PRBC transfusion when preoperative low-dose (≤160 mg/d) aspirin was administered. Aspirin at any dose is associated with decreased mortality and AKI and low-dose aspirin (≤160 mg/d) decreases the incidence of perioperative MI.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Nineteen observational studies reported PRBC transfusion rates. The analysis was based on the results from 18 392 patients.…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

et al. 2017

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Effect of Perioperative Antithrombotics on Postoperative Transfusion and Hematoma in Head and Neck Free Flaps

Hicks,

Vasudev,

Bishop

et al. 2023

OTO Open

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ObjectiveTo explore if antiplatelet or anticoagulant therapy increases the risk of transfusion requirement or postoperative hematoma formation in patients undergoing microvascular reconstruction for head and neck defects.Study DesignRetrospective cohort study.SettingDepartments of Otolaryngology–Head and Neck Surgery at the University of Alabama at Birmingham, the University of Colorado, and the University of California Irvine.MethodsA multi‐institutional, retrospective review on microvascular reconstruction of the head and neck between August 2013 to July 2021. Perioperative antithrombotic data were collected to examine predictors of postoperative transfusion and hematoma.ResultsA total of 843 free flaps were performed. Preoperative hemoglobin, hematocrit, operative time, and flap type were positive predictors of postoperative transfusion in both bivariate (P < .0001) and multivariate analyses (P < .0001). However, neither anticoagulation nor antiplatelet therapy were predictive of postoperative transfusion rates and hematoma formation.ConclusionAntithrombotic regimens do not increase the risk of postoperative transfusion or hematoma in head and neck microvascular reconstruction. Based on this limited data, perioperative antithrombotic regimens can be considered in patients who may otherwise be at risk for these postoperative complications.

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Postoperative Bleeding and Acute Kidney Injury in Esophageal Cancer Patients Receiving Ketorolac

Corsini

Zhou

Antonoff

et al. 2021

The Annals of Thoracic Surgery

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Preoperative Aspirin Does Not Increase Transfusion or Reoperation in Isolated Valve Surgery

Cited by 7 publications

References 19 publications

The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

The use of preoperative aspirin in cardiac surgery: A systematic review and meta-analysis

Effect of Perioperative Antithrombotics on Postoperative Transfusion and Hematoma in Head and Neck Free Flaps

Postoperative Bleeding and Acute Kidney Injury in Esophageal Cancer Patients Receiving Ketorolac

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