Preoperative Anemia as a Prognostic Factor in Endometrioid-Type Endometrial Carcinoma

Abu‐Zaid, Ahmed; Alsabban, Mohannad; Abuzaid, Mohammed; Alomar, Osama; Salem, Hany; Al‐Badawi, Ismail A.

doi:10.1016/j.jogc.2018.05.005

Cited by 4 publications

(1 citation statement)

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“…Patients whose disease progressed to more advanced stages and those who presented with an unfavorable differentiation grade, myometrial invasion ≥50%, lymphovascular invasion, or tumor recurrence had significantly lower preoperative hemoglobin levels when compared with patients who did not present with anemia in the preoperative period. This study indicated that patients with preoperative anemia had significantly lower recurrence-free survival rates after five years and significantly lower OS rates when compared with patients without preoperative anemia, demonstrating that the preoperative hemoglobin rate is a prognostic factor with an important clinical significance 23 . By evaluating the association of laboratory parameters with prognostic factors in uterine cancer, lower hemoglobin values were related to stages II to IV when compared with stage I and nonendometrioid histological type and also when compared with endometrioid subtype.…”

Section: Discussionmentioning

confidence: 68%

Association of laboratorial parameters and prognostic factors in uterine corpus cancer

Bezerra

Martins-Filho

Sousa

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aims were to compare the red blood cells, platelet count, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, red cell distribution width, and fasting glucose in peripheral blood of patients with benign and malignant uterine neoplasms and to relate these laboratory parameters with prognostic factors and overall survival in cancer. METHODS:The results of the laboratory parameters were analyzed using the Mann-Whitney U test. Receiver operating characteristic curves were used to find the cutoff values. Overall survival was estimated using the Kaplan-Meyer method.RESULTS: Higher values of neutrophil-lymphocyte ratio and fasting glucose were found in cancer patients. Higher platelet-lymphocyte ratio values were associated with other subtypes when compared with endometrioid subtype; higher values of red cell distribution width were found in stage II/IV when compared with stage I; lower hemoglobin values were related to stage II/IV and nonendometrioid histological type. Platelet-lymphocyte ratio <145.56 was associated with longer overall survival.CONCLUSION: Hemoglobin and platelet-lymphocyte ratio values are prognostic factors in uterine corpus cancer.

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Section: Discussionmentioning

confidence: 68%

Association of laboratorial parameters and prognostic factors in uterine corpus cancer

Bezerra

Martins-Filho

Sousa

et al. 2021

Rev. Assoc. Med. Bras.

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Preoperative anemia predicts poor prognosis in patients with endometrial cancer: A systematic review and meta-analysis

Abu‐Zaid

Alomar

Abuzaid

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

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Association of Myometrial Invasion With Lymphovascular Space Invasion, Lymph Node Metastasis, Recurrence, and Overall Survival in Endometrial Cancer: A Meta-Analysis of 79 Studies With 68,870 Patients

Wang

Yang

et al. 2021

Front. Oncol.

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BackgroundMyometrial invasion has been demonstrated to correlate to clinicopathological characteristics and prognosis in endometrial cancer. However, not all the studies have the consistent results and no meta-analysis has investigated the association of myometrial invasion with lymphovascular space invasion (LVSI), lymph node metastasis (LNM), recurrence, and overall survival (OS). Therefore, a meta-analysis was performed to evaluate the relationship between myometrial invasion and clinicopathological characteristics or overall survival in endometrial cancer.Materials and MethodsA search of Pubmed, Embase, and Web of Science was carried out to collect relevant studies from their inception until June 30, 2021. The quality of each included study was evaluated using Newcastle–Ottawa scale (NOS) scale. Review Manager version 5.4 was employed to conduct the meta-analysis.ResultsA total of 79 articles with 68,870 endometrial cancer patients were eligible including 9 articles for LVSI, 29 articles for LNM, 8 for recurrence, and 37 for OS in this meta-analysis. Myometrial invasion was associated with LVSI (RR 3.07; 95% CI 2.17–4.35; p < 0.00001), lymph node metastasis (LNM) (RR 4.45; 95% CI 3.29–6.01; p < 0.00001), and recurrence (RR 2.06; 95% CI 1.58–2.69; p < 0.00001). Deep myometrial invasion was also significantly related with poor OS via meta-synthesis of HRs in both univariate survival (HR 3.36, 95% CI 2.35–4.79, p < 0.00001) and multivariate survival (HR 2.00, 95% CI 1.59–2.53, p < 0.00001). Funnel plot suggested that there was no significant publication bias in this study.ConclusionDeep myometrial invasion correlated to positive LVSI, positive LNM, cancer recurrence, and poor OS for endometrial cancer patients, indicating that myometrial invasion was a useful evaluation criterion to associate with clinical outcomes and prognosis of endometrial cancer since depth of myometrial invasion can be assessed before surgery. The large scale and comprehensive meta-analysis suggested that we should pay more attention to myometrial invasion in clinical practice, and its underlying mechanism also deserves further investigation.

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Preoperative Anemia as a Prognostic Factor in Endometrioid-Type Endometrial Carcinoma

Cited by 4 publications

References 12 publications

Association of laboratorial parameters and prognostic factors in uterine corpus cancer

Association of laboratorial parameters and prognostic factors in uterine corpus cancer

Preoperative anemia predicts poor prognosis in patients with endometrial cancer: A systematic review and meta-analysis

Association of Myometrial Invasion With Lymphovascular Space Invasion, Lymph Node Metastasis, Recurrence, and Overall Survival in Endometrial Cancer: A Meta-Analysis of 79 Studies With 68,870 Patients

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