Preoperative Albumin–Bilirubin Grade Predicts Recurrences After Radical Gastrectomy in Patients with pT2‐4 Gastric Cancer

Kanda, Mitsuro; Tanaka, Chie; Kobayashi, Daisuke; Uda, Hiroaki; Inaoka, Kenichi; Tanaka, Yuri; Hayashi, Masamichi; Iwata, Nakao; Yamada, Suguru; Fujii, Tsutomu; Sugimoto, Hiroyuki; Murotani, Kenta; Fujiwara, Michitaka; Kodera, Yasuhiro

doi:10.1007/s00268-017-4234-x

Cited by 44 publications

(51 citation statements)

References 41 publications

(45 reference statements)

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“…Thus, a proper preoperative assessment of the nutritional status of gastric cancer patients should be performed. Numerous studies have sought to develop a reliable, valid scoring system that can identify patients with poor nutritional status and some systems have been used successfully to predict complications after gastrectomy [36][37][38].…”

Section: Nutritionmentioning

confidence: 99%

Preoperative predictors of postoperative complications after gastric cancer resection

Kanda¹

2019

Surg Today

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Risk management is becoming an increasingly important healthcare issue. Gastrectomy with lymphadenectomy is still the mainstay of treatment for localized gastric cancer, but it is sometimes associated with postoperative complications that compromise the patient's quality of life, tolerability of adjuvant treatment, and prognosis. Parameters based exclusively on preoperative factors can identify patients most at risk of postoperative complications, whereby surgeons can provide the patient with precise informed consent information and optimal perioperative management. Ultimately, these predictive tools can also help minimize medical costs. In this context, many studies have identified factors that predict postoperative complications, including indicators based on body constitution, nutrition, inflammation, organ function and hypercoagulation. This review presents our current understanding and discusses some future perspectives of preoperatively identified factors predictive of complications after resection for gastric cancer.

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Section: Nutritionmentioning

confidence: 99%

Preoperative predictors of postoperative complications after gastric cancer resection

Kanda¹

2019

Surg Today

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“…Moreover, several studies have found that ALBI is associated with prognostic factors for disease-free survival and overall survival 13. Kanda et al18 reported that ALBI grade 2 patients were more likely to have shorter disease-specific and disease-free survival after radical gastrectomy, compared with that for ALBI grade 1 patients. Additionally multivariable analysis identified ALBI grade 2 as an independent prognostic factor for disease-free survival.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the albumin-bilirubin score as a prognostic factor for early recurrence after curative hepatic resection for hepatocellular carcinoma

Lee

Koh

Hur

et al. 2018

Ann Hepatobiliary Pancreat Surg

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Backgrounds/AimsThe albumin-bilirubin (ALBI) score has been validated as a predictor of disease-free survival and overall survival in hepatocellular carcinoma (HCC). The purpose of this study was to assess the ALBI score as a risk factor for early recurrence (ER) after curative liver resection in HCC.MethodsPatients who underwent liver resection with curative intent for HCC without previous treatment between January 2004 and December 2014 were included in this retrospective study. The utility of the ALBI score in predicting ER and late recurrence (LR) was evaluated.ResultsA total of 465 HCC patients were enrolled; multivariate analysis identified ALBI grade ≥2 (p=0.003) as a risk factor for ER, in addition to hepatitis B virus surface antigen (HBsAg)-positive status (p<0.001), tumor size ≥3.5cm (p≤0.001), lymph-vascular invasion (p=0.001), and the presence of satellite lesions (p=0.009). In subgroup analysis for ALBI grade 1, Model for End-stage Liver Disease score >9 (p=0.046), HBsAg positive status (p=0.004), tumor size ≥3.5 cm (p<0.001), lymph-vascular invasion (p=0.001), presence of satellite lesions (p=0.002), and poor tumor differentiation (p=0.007) were independent risk factors for ER; however, in subgroup analysis for ALBI grade 2, no significant associations with ER were found. Kaplan-Meier curve analysis showed that long-term survival in HCC with ER was significantly shorter than in patients with LR.ConclusionsThe ALBI score was a preoperative risk factor for ER and may be useful in determining appropriate management according to liver function when recurrence develops.

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“…Alb and bilirubin concentrations to determine the ALBI score are easily measured using standard laboratory tests in most hospitals. Moreover, the ALBI score can serve as a prognostic factor for certain malignancies [91315]. This study revealed that high ALBI scores are associated with shorter time to failure of postoperative adjuvant S-1 monotherapy and caused shorter DFS.…”

Section: Discussionmentioning

confidence: 93%

“…These parameters can be determined by preoperative routine blood test at any hospital and were potentially correlated to nutritional status and functions of the liver, kidney and bone marrow. The following data were retrospectively retrieved from the medical records: white blood cell count, neutrophil count, total lymphocyte count (TLC), platelet count (Plt), total protein, albumin (Alb), cholinesterase, total bilirubin (T-Bil), aspartate aminotransferase, alanine aminotransferase, indices as candidate predictors: CCr (Cockroft-Gault method), ALBI score [ALBI=log10 T-Bil (µmol/L)×0.66+Alb (g/L)×−0.0852], platelet-lymphocyte ratio (PLR) (PLR=TLC/Plt×100), Onodera's prognostic nutritional index (PNI) (PNI=10×Alb g/dL+0.005×TLC) [1213].…”

Section: Methodsmentioning

confidence: 99%

Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy

et al. 2019

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Purpose Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in gastric cancer (GC) patients, we evaluated the predictive values of blood indicators. Materials and Methods We analyzed 98 patients with pStage II/III GC who underwent postoperative adjuvant S-1 monotherapy. We retrospectively analyzed correlations between 14 parameters obtained from perioperative routine blood tests to assess their influence on the withdrawal of postoperative adjuvant S-1 monotherapy, within 6 months after discontinuation. Results Postoperative adjuvant chemotherapy was discontinued in 21 patients (21.4%) within 6 months. Univariable analysis revealed that high preoperative albumin-bilirubin (ALBI) scores had the highest odds ratio (OR) for predicting the failure of adjuvant S-1 chemotherapy (OR, 6.47; 95% confidence interval [CI], 2.08–20.1; cutoff value, –2.696). The high ALBI group had a significantly shorter time to failure of postoperative adjuvant S-1monotherapy (hazard ratio, 3.48; 95% CI, 1.69–7.25; P=0.001). Multivariable analysis identified high preoperative ALBI score as an independent prognostic factor for tolerability (OR, 10.3; 95% CI, 2.33–45.8; P=0.002). Conclusions Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC.

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Preoperative Albumin–Bilirubin Grade Predicts Recurrences After Radical Gastrectomy in Patients with pT2‐4 Gastric Cancer

Abstract: ALBI grade serves as a simple and promising predictive factor for disease-free and disease-specific survival in patients with pT2-4 GC after radical gastrectomy.

Cited by 44 publications

References 41 publications

Preoperative predictors of postoperative complications after gastric cancer resection

Preoperative predictors of postoperative complications after gastric cancer resection

Effectiveness of the albumin-bilirubin score as a prognostic factor for early recurrence after curative hepatic resection for hepatocellular carcinoma

Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy

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