Preoperative acute pancreatitis and hyperenzymemia are associated with poor prognosis in patients with nonfunctional pancreatic neuroendocrine tumors

Abstract

Background We aimed to investigate the prevalence of acute pancreatitis (AP) and hyperenzymemia as well as their clinical impact on postoperative survival outcomes in patients with pancreatic neuroendocrine tumors (PNETs). Methods A retrospective cohort study of 218 patients who underwent radical surgical resection for nonfunctional PNETs (NF‐PNETs) was conducted. Multivariate survival analysis was performed by the Cox proportional hazard model, with results expressed as hazard ratio (HR) and 95% confidence interval (CI). Results Of the 151 patients who met the inclusion criteria, the incidences of preoperative AP and hyperenzymemia were 7.9% (12/152) and 23.2% (35/151), respectively. The mean recurrence‐free survival (RFS, 95% CI) for patients in control, AP, and hyperenzymemia groups was 136 (127–144), 88 (74–103), and 90 (61–122) months, with a 5‐year RFS rate of 86.5%, 58.3%, and 68.9%, respectively. In the multivariable‐adjusted Cox hazard model that included tumor grade and lymph node status, the adjusted HR of AP and hyperenzymemia for recurrence was 2.58 (95% CI: 1.47–7.86, p = 0.008) and 2.43 (95% CI: 1.08–7.06, p = 0.040). Conclusion Preoperative AP and hyperenzymemia are associated with poor RFS following radical surgical resection in NF‐PNETs patients.