Preoperative 18F-FDG PET/CT predicts disease-free survival in patients with primary invasive ductal breast cancer

Abstract

A high primary tumor SUVmax on 18F-FDG PET/CT was an independent factor associated with worse disease-free survival in patients with primary invasive ductal breast cancer.

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I-III breast cancer: Multicenter study

“…As for tumor subtype in the present cohort, the mean maximum SUVmax values for HER2-positive and triple-negative tumors were 7.92 ± 4.59 and 7.16 ± 4.40, respectively, both higher than that for ER-positive/HER2negative tumors (4.59 ± 3.40) (p < 0.001 and p < 0.001, respectively), findings similar to previous reports [4,6,18]. Other studies of breast cancer have found that primary tumor quantitative FDG-PET/CT parameters are correlated with known prognostic pathological parameters, while those were also shown useful for prognosis prediction without the need for division according to molecular subtype [2,[4][5][6]. More recently, reports regarding the usefulness of volume-based quantitative parameters (SUVmax, MTV, TLG) for predicting prognosis using major receptor types have been presented.…”

“…Although previous studies of stage operable breast cancer patients only evaluated primary tumor quantitative FDG-PET/CT values as imaging biomarkers [2,[4][5][6][18][19][20][21], cases with a lower primary tumor SUVmax value as compared to that for nodal SUVmax are commonly encountered in clinical situations. In the present cohort as well, it was observed in 10.2-30.9% and we defined that as maximum SUVmax, which is considered to be a strong point of this report.…”

“…Recently, noninvasive diagnostic tools have been gaining popularity for prediction of tumor behavior, with magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) with magnetic resonance imaging (MRI) reported to provide surrogate imaging biomarkers showing correlations with clinicopathological prognostic factors [2,3]. In addition, standardized uptake value (SUV), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG) derived from 18 F-fluorodeoxyglucose positron emission tomography/ computed tomography (FDG-PET/CT) findings are reported to have correlations with clinicopathological prognostic factors and considered to be prognosis prediction factors [2][3][4][5][6].…”

Low-dose High-resolution 18F-FDG-PET/CT Using Time-of-flight and Point-spread Function Reconstructions: A Role in the Detection of Breast Carcinoma Axillary Lymph Node Metastases

“…However, this is not a diagnostic imaging modality for the presence of metastatic lymph node involvement, but only a sign of the degree of lymphatic drainage. In contrast, 18 F-FDG-PET/CT is a method that directly evaluates metastatic infiltration (2,3,5) and is also relevant for prognosis of the disease (5,6). When evaluating axillary nodes, false-negative and false-positive findings may be obtained.…”

Present and future role of FDG-PET/CT imaging in the management of breast cancer

“…Mastectomy performed upon completion of NAC (eight courses) showed no pCR 1 3 controversial. Several authors have suggested that SUV in primary breast cancer [10,[96][97][98][99] or in axillary LN metastasis [34,100] could be predictive of outcome. Jo et al [99] evaluated whether preoperative SUV max of the primary tumor was associated with DFS in 508 patients with invasive ductal breast cancer, along with histological and biological factors such as tumor size, histological grade, or hormonal receptor expression status, and concluded that a high primary tumor SUV max is an independent factor associated with recurrence.…”