Prenylflavonoids from Artocarpus elasticus

Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)

“…From benzene-and chloroform-soluble fractions of the methanol extract from the heartwood of A. lanceifolius, several prenylflavone derivatives basically based on 3,6,8-triprenylated flavone possesing a 2¢,4¢-dioxygenated B-ring were isolated [39]. They included three new compounds, trivially named artoindonesianins G-I (26-28), together with known compounds, artelastofuran (29) [40] and artelasticin (30) [41] (Fig. 10).…”

“…This new compound, named artoindonesianin Z-3 (40), was isolated as a minor constituent from a preliminary benzene-soluble fraction of the acetone extract together with artonol B (38), resorcyl aldehyde (41) and gallyl aldehyde (42) [48] (Fig. 14).…”

The natural prenylated flavone artelastin is an inhibitor of ROS and NO production

“…1), previously isolated by us from Artocarpus elasticus [9], on the production of ROS and NO. Two different stimuli (OPZ and PMA) were selected for ROS production by human PMNs in order to have a representative of each of the two different pathways of respiratory burst activation.…”

An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells

“…In this region, particularly in the west part of Java, this plant has been used to treat inflammation, female contraception (bark), dysentery (latex), and tuberculosis (young leaves) (Heyne, 1987). A literature survey disclosed that a number of chemical and biological studies have been carried out on this plant (Kijjoa et al, 1996;Nascimento et al, 1997;Cidade et al, 2001;Pedro et al, 2005;Ko et al, 2005;Cerqueira et al, 2008), and revealed that 3-prenylflavones, pyranoflavones, furanodihydrobenzoxanthonetype of flavones, and oxepinoflavones are the major flavonoids isolated. In continuation of our work aimed at finding new cytotoxic metabolites of Artocarpus (Hakim et al, 2006;Syah et al, 2006a;2006b, 2006c, we have examined wood samples of this plant and have isolated a new oxepinoflavone, which we named artoindonesianin E1 (1) (Fig.…”