Prenylation of oncogenic human PTPcaax protein tyrosine phosphatases

Cates, Carolyn A.; Michael, Rodney L.; Stayrook, Keith R.; Harvey, Kevin; Burke, Yvette D.; Randall, Stephen K.; Crowell, Pamela L.; Crowell, Dring N.

doi:10.1016/s0304-3835(96)04459-x

Cited by 194 publications

(198 citation statements)

References 18 publications

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“…Overexpression of this gene in epithelial cells induced a transformed phenotype in culture and tumor growth in nude mice. 39 In contrast, cluster 7A comprises genes which were more weakly expressed in cervical cancers compared to CIN3. An interesting gene in this cluster is 14-3-3sigma (cluster 7A, B03m), which is also known as stratifin and HME1.…”

Section: Discussionmentioning

confidence: 99%

Detection of cancer‐related gene expression profiles in severe cervical neoplasia

Sopov

Magbagbeolu

et al. 2004

Intl Journal of Cancer

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The molecular signatures of 20 severe cervical intraepithelial neoplasia (CIN3) cases and 10 cervical squamous cell cancers were determined to define cancer-related gene expression profiles. RNAs extracted from microdissected tissues were amplified by SMART technology and used as probes for hybridization of commercially available cDNA array filters comprising 1,176 cancer-related genes. Ninetytwo differentially expressed genes were identified by comparison of pooled cDNA from CIN3 vs. cervical cancer. Heterogeneity in expression of this subset of genes was then analyzed for each biopsy using an algorithm for self-organizing maps. For several gene clusters, the expression pattern for CIN3 differed significantly from that of cancer. Moreover, hierarchical clustering revealed significant differences in distribution of CIN and cancer. Several CIN cases were more strongly related to cancer, suggesting that gene expression profiling may be useful for subdividing pathologically indistinguishable precancers into different biologic entities. This approach also provides a basis for the identification of putative prognostic markers and for targeted molecular therapy.

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Section: Discussionmentioning

confidence: 99%

Detection of cancer‐related gene expression profiles in severe cervical neoplasia

Sopov

Magbagbeolu

et al. 2004

Intl Journal of Cancer

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“…PRL-3 has been shown to influence proliferation, migration, and metastasis of cancer cells in vitro and in vivo (Cates et al, 1996;Wang et al, 2002;Zeng et al, 2003). Several studies have demonstrated the relevance of tumour angiogenesis for these particular tumour cell properties (Folkman and Klagsbrun, 1987;Hanahan and Weinberg, 2000;Alberts, 2002;Ambler et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…PRL-1 was the first to be identified, originally as an immediate early gene, the expression of which was induced in mitogen-stimulated cells and in regenerating liver, therefore named 'protein of regenerating liver' (PRL) (Mohn et al, 1991;Montagna et al, 1995). Overexpression of PRL-1 and PRL-2 has been found to transform mouse fibroblasts and pancreatic epithelial cell in vitro and to promote tumour growth in nude mice, suggesting that they might play a role in tumourigenesis (Diamond et al, 1994;Cates et al, 1996). Migration and invasion have been shown to be enhanced by PRL-3 and PRL-1 expression in Chinese hamster ovary cells and overexpression of these proteins induced metastatic tumour formation in mice (Zeng et al, 2003).…”

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confidence: 99%

Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer

et al. 2006

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The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-PTP mRNA expression was examined in malignant (n ¼ 7) and nonmalignant (n ¼ 7) cryoconserved breast tissue samples as well as in eight breast cancer cell lines by RT -PCR. Furthermore, protein expression of PRL-3 was analysed semiquantitatively by immunohistochemistry in ductal breast carcinoma in situ (n ¼ 135) and invasive breast cancer (n ¼ 147) by use of tissue microarray technology (TMA). In 24 lymph node-positive patients we selected the corresponding lymph node metastases for analysis of PRL-3 expression, and a validation set (n ¼ 99) of invasive breast cancer samples was examined. Staining results were correlated with clinicopathological parameters and long-term follow-up. PRL-3 mRNA expression was significantly higher in malignant compared to benign breast tissue. For PRL-1 and PRL-2 expression no significant differences were observed. Staining of TMAs showed PRL-3 expression in 85.9% ductal carcinoma in situ and 75.5% invasive breast carcinomas. Analysis of survival parameters revealed a shorter disease-free survival (DFS) in patients with PRL-3-positive carcinomas, and in particular a significantly shorter DFS in nodal-positive patients with PRL-3 overexpressing tumours as compared to PRL-3-negative breast carcinomas (6677 months (95% CI, 52 -80) vs 9779 months (95% CI, 79 -115); P ¼ 0.032). Moreover, we found a more frequent expression of PRL-3 in lymph node metastases as compared to the primary tumours (91.7 vs 66.7%; P ¼ 0.033). Our results suggest that PRL-3 might serve as a novel prognostic factor in breast cancer, which may help to predict an adverse disease outcome.

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“…4,5 Overexpression of PRL-1 and PRL-2 in epithelial cells results in a transformed phenotype in culture and tumor growth in nude mice. 6,7 By PCR-based subtractive hybridization, PRL-2 was shown to be upregulated 1.8, 2.7 and 4.0 times in advanced prostate cancer cell lines LNCaP, PC-3 and DU-145, respectively, in comparison with normal epithelial cells. Subsequently, PRL-2 was suggested to be associated with prostate tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Catalytic domain of PRL-3 plays an essential role in tumor metastasis: Formation of PRL-3 tumors inside the blood vessels

Guo¹,

Li²,

Tang³

et al. 2004

Cancer Biology & Therapy

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Prenylation of oncogenic human PTPcaax protein tyrosine phosphatases

Cited by 194 publications

References 18 publications

Detection of cancer‐related gene expression profiles in severe cervical neoplasia

Detection of cancer‐related gene expression profiles in severe cervical neoplasia

Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer

Catalytic domain of PRL-3 plays an essential role in tumor metastasis: Formation of PRL-3 tumors inside the blood vessels

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