Prenylated flavonoids from the stem wood of Commiphora opobalsamum (L.) Engl. (Burseraceae)

Suleiman, Mohamed Hammad Adam

doi:10.1016/j.jksus.2014.04.005

Cited by 10 publications

(7 citation statements)

References 19 publications

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“…All the compounds were first tested for their potential toxicity on cell monolayer at different concentrations: furanodienone (1), curzerene (3) and β-elemene (4) at a range of 30-500 µg/mL; furanoeudesma-1,3-diene (2) at 2.5-30 µg/mL (due to the availability of a low amount of the standard compound). We found that compounds 1 and 3 showed toxicity at higher doses (starting from 100 µg/mL), while compound 4 was highly toxic at all the concentrations used.…”

Section: Resultsmentioning

confidence: 99%

“…Compounds were added at different concentrations (30, 60 and 100 µg/mL) after the infection and maintained for the following 24 h. Viral replication was measured by means of HAU/mL. As shown in Table 4, compounds furanodienone (1) and curzerene (3) were Figure 3. The mixture myrrh oil and Vit.…”

Section: Resultsmentioning

confidence: 99%

“…However, the highest concentration of 100 µg/mL was quite toxic for both compounds, therefore, we chose a lower concentration to exclude that the antiviral activity may be in part due to the cytotoxicity of compounds. Therefore, to deepen the mechanism of action of furanodienone (1) and curzerene (3), 80 µg/mL was added to cells at different steps of infection: only before infection (2 h, PRE), only during infection (1 h, DUR), immediately after infection and maintained for the following 24 h (POST). Compounds were also maintained for all the time of infection (before, during and after) but in this condition, they both became toxic for the cells, and data were not considered valid.…”

Section: Resultsmentioning

confidence: 99%

“…Commiphora genus (Burseraceae) includes more than 150 species especially occurring in northeastern Africa, southern Arabia and India [ 1 ]. The species Commiphora myrrha (Nees) Engl.…”

Section: Introductionmentioning

confidence: 99%

“…Compounds 1 and 3 affect different steps of virus lifecycle. A549 cells were infected with PR8 and treated or not with furanodienone(1) or curzerene (3) at different phases of the virus life cycle: the compounds were added for 2 h before (PRE); during viral adsorption for 1 h (DUR); immediately after viral adsorption and maintained for 24 h (POST). After 24 h infection, supernatants were recovered and used to infect a fresh monolayer of MDCK cells.…”

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confidence: 99%

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Investigation of Commiphora myrrha (Nees) Engl. Oil and Its Main Components for Antiviral Activity

et al. 2021

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The resinous exudate produced by Commiphora myrrha (Nees) Engl. is commonly known as true myrrh and has been used since antiquity for several medicinal applications. Hundreds of metabolites have been identified in the volatile component of myrrh so far, mainly sesquiterpenes. Although several efforts have been devoted to identifying these sesquiterpenes, the phytochemical analyses have been performed by gas-chromatography/mass spectrometry (GC–MS) where the high temperature employed can promote degradation of the components. In this work, we report the extraction of C. myrrha by supercritical CO2, an extraction method known for the mild extraction conditions that allow avoiding undesired chemical reactions during the process. In addition, the analyses of myrrh oil and of its metabolites were performed by HPLC and GC–MS. Moreover, we evaluated the antiviral activity against influenza A virus of the myrrh extracts, that was possible to appreciate after the addition of vitamin E acetate (α-tocopheryl acetate) to the extract. Further, the single main bioactive components of the oil of C. myrrha commercially available were tested. Interestingly, we found that both furanodienone and curzerene affect viral replication by acting on different steps of the virus life cycle.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Commiphora genus (Burseraceae) includes more than 150 species especially occurring in northeastern Africa, southern Arabia and India [ 1 ]. The species Commiphora myrrha (Nees) Engl.…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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