Prenylated Flavonoids from Epimedium koreanum Nakai and their Human Neutrophil Elastase Inhibitory Effects

Lee, Soo Min; Song, Yeong Hun; Uddin, Zia; Ban, Yeong Jun; Park, Ki Hun

doi:10.25135/rnp.66.17.05.090

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Compound 23 (tR = 19.10 min) was tentatively identified as Neophellamuretin based on the molecular ion ([M+H + ]) at m / z of 357.13 and two main fragments at m / z 325.10 [M+H-2OH] + and 253.09 [M+H-C5H10O2] + . Neophellamuretin was found in Epimedium koreanum Nakai [ 21 ] and Desmodium caudatum [ 22 ]. This is the first time that Neophellamuretin was found to be present in mulberry seeds or other mulberry matrices.…”

Section: Resultsmentioning

confidence: 99%

Identification and Antioxidant Capacity of Free and Bound Phenolics in Six Varieties of Mulberry Seeds Using UPLC-ESI-QTOF-MS/MS

Gao

Guo

Wang³

et al. 2022

Antioxidants

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Mulberry seeds are a byproduct of juice processing and may be an important resource for its abundant compounds. In this study, we analyzed the qualitative composition of free and bound phenolics from six varieties of mulberry seeds using UPLC-ESI-QTOF-MS/MS. Free phenolics (FPs) and bound phenolics (BPs) were measured using the Folin–Ciocalteu method; antioxidant capacity was determined by measuring 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, using the ferric reducing antioxidant power assay. A total of 28 free and 11 bound phenolics were extracted and identified, wherein five free phenolics were found in mulberry matrices for the first time. The six varieties of mulberry seeds exhibited higher content of FPs than BPs, and there was a correlation between the phenolic content and antioxidant capacity. Consequently, three varieties were selected for their high phenolic content and antioxidant capacity. This study might offer a theoretical basis for the utilization of mulberry seed.

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Section: Resultsmentioning

confidence: 99%

Identification and Antioxidant Capacity of Free and Bound Phenolics in Six Varieties of Mulberry Seeds Using UPLC-ESI-QTOF-MS/MS

Gao

Guo

Wang³

et al. 2022

Antioxidants

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“…Most of the phenolics and flavonoids are able to inhibit elastase activity according to their concentration. 32,33 The major chemical constituents of apricot seeds previously measured are phenolics, flavonoids, carotenoids and amygdalin. From all these results, we can conclude the amygdalin has more powerful anti-ageing effect than ethanol apricot seeds extract.…”

Section: Collagenase and Elastase Enzymes Inhibition Assaymentioning

confidence: 99%

A Potent Anti-Ageing and Immunomodulatory Activity of Apricot Seed Standardized Extract and its Major Compound; Amygdalin

2020

TJNPR

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Apricot seeds are the kernel derived from Prunus armeniaca L. which belongs to family Rosaceae. Apricot is cultivated in South Africa, Asian countries, South Europe, and Australia. 1 The apricot seeds have been used to treat several skin infections, and to dehydrate, nourish, and lubricate the skin. 2 It was reported to have antiseptic, anti-oxidant, and anti-inflammatory remedy. 3 It is used traditionally as antitussive agent in asthma and bronchitis disorders. The oil of these seeds is commonly used in skin care products and in drug combinations as ingredients with medical importance. 4 Amygdalin is a well-known glycoside containing cyanide and present in seeds of plants related to Rosacea family, reported as beneficial adjuvant in cancer treatment. 5 Skin ageing is an unavoidable progression and all living organisms can suffer from it appearing in their skin. There are 2 types of skin ageing according to the cause, intrinsic and extrinsic ageing. Intrinsic skin ageing is due to changes in elasticity over time and known as agedependent/chronological, where extrinsic is caused by the direct exposure to UV light and other destructive agents, so it is known as

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Phytochemistry and pharmacology of natural prenylated flavonoids

Wang

Luo

et al. 2023

Arch. Pharm. Res.

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Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value. Supplementary Information The online version contains supplementary material available at 10.1007/s12272-023-01443-4.

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Prenylated Flavonoids from Epimedium koreanum Nakai and their Human Neutrophil Elastase Inhibitory Effects

Cited by 7 publications

References 21 publications

Identification and Antioxidant Capacity of Free and Bound Phenolics in Six Varieties of Mulberry Seeds Using UPLC-ESI-QTOF-MS/MS

Identification and Antioxidant Capacity of Free and Bound Phenolics in Six Varieties of Mulberry Seeds Using UPLC-ESI-QTOF-MS/MS

A Potent Anti-Ageing and Immunomodulatory Activity of Apricot Seed Standardized Extract and its Major Compound; Amygdalin

Phytochemistry and pharmacology of natural prenylated flavonoids

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