Prenylated chalcones and flavones from the leaves of dorstenia kameruniana

Abegaz, Berhanu M.; Ngadjui, Bonaventure T.; Dongo, Étienne; Tamboue, Hélène

doi:10.1016/s0031-9422(98)00061-2

Cited by 66 publications

(34 citation statements)

References 9 publications

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“…The post-chlorophyll fractions were combined and purified successively on column openUP (May 2008) chromatography followed by preparative TLC to yield: isobavachalcone (1, 98 mg, MW: 324, mp: 171-172) (Abegaz et al, 1998) and stipulin (2, 20 mg, MW: 392, mp: 122-123) (Abegaz et al, 1998 …”

Section: Isolation and General Proceduresmentioning

confidence: 99%

“…In Cameroon, the leaves and twigs of Dorstenia barteri Bureau are used as decoction in the treatment of mumps, yaws and infected wounds ([Thomas et al, 1989], [Abegaz et al, 1998] and [Tsopmo et al, 1999]). This genus is a rich source of flavonoids such as prenylated and geranylated chalcones, and coumarins ( [Abegaz et al, 2004] and [Ngameni et al, 2007]).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Mbaveng

Ngameni

Kuete

et al. 2008

Journal of Ethnopharmacology

154

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The aim of this study was to evaluate the antimicrobial activity of the crude extract of the twigs of Dorstenia barteri (DBT) as well as that of four of the five flavonoids isolated from this extract. Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and fungi (four species) were used. The agar disc diffusion test was used to determine the sensitivity of the tested samples while the well micro-dilution was used to determine the minimal inhibition concentrations (MIC) and the minimal microbicidal concentration (MMC) of the active samples. The results of the disc diffusion assay openUP (May 2008) showed that DBT, isobavachalcone (1), and kanzonol C (4) prevented the growth of all the 22 tested microbial species. Other compounds showed selective activity. The inhibitory activity of the most active compounds namely compounds 1 and 4 was noted on 86.4% of the tested microorganisms and that of 4-hydroxylonchocarpin (3) Abbreviations

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Section: Isolation and General Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Mbaveng

Ngameni

Kuete

et al. 2008

Journal of Ethnopharmacology

154

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“…2,3) Species of the genus Dorstenia (Moraceae) are perennial, herbaceous plants that are widely distributed in tropical Africa, Asia, Middle-East, Central and South America. 4,5) Moraceae comprises a large family of sixty genera and nearly 1400 species, including important groups such as Artocarpus, Morus, and Ficus. The species of Morus have been shown to exhibit anti-HIV, anti-oxidative, anti-hypotensive, and cytotoxic activities.…”

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confidence: 99%

Inhibitory Effects of Morus alba on Compound 48/80-Induced Anaphylactic Reactions and Anti-Chicken Gamma Globulin IgE- Mediated Mast Cell Activation

Chai

Lee

Han

et al. 2005

Biological & Pharmaceutical Bulletin

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Mast cells are widely distributed throughout vascularized tissues and certain epithelia.1) Mast cells are responsible for a variety of allergic disorders including allergic rhinitis, dermatitis, asthma, and food allergies, as well as catastrophic anaphylactic reactions to insect stings and some drugs. These cells respond to IgE-directed antigens via the high-affinity receptor for IgE, Fce RI, by releasing granules that contain preformed inflammatory mediators and generating inflammatory lipids and cytokines. 2,3) Species of the genus Dorstenia (Moraceae) are perennial, herbaceous plants that are widely distributed in tropical Africa, Asia, Middle-East, Central and South America. 4,5) Moraceae comprises a large family of sixty genera and nearly 1400 species, including important groups such as Artocarpus, Morus, and Ficus. The species of Morus have been shown to exhibit anti-HIV, anti-oxidative, anti-hypotensive, and cytotoxic activities. [6][7][8] Plants of this genus are known to be rich in flavonoids, 9,10) a group of chemicals shown to have potent antiviral activities against herpes simplex virus, rhinovirus, human immunodeficiency virus, and various respiratory viruses. [11][12][13] This herb has been long used as an antiphlogistic, diuretic, and expectorant, 14) and also applied for control of inflammation, diabetes, and bronchial asthma. 15,16) The phenolic constituents and flavonoids of mulberry tree inhibits cAMP phosphodiesterase activity and regulates arachidonate metabolism in rat platelet homogenates. 17) Although studies have demonstrated that various effects of M. alba on numerous disease, the anti-allergic activity of the root bark of M. alba is poorly understood. Since calcium and cAMP have been shown to play a pivotal role in the mast cell activations, we have assessed the effect of the root bark of M. alba on calcium uptake and change of intracellular cAMP in mast cells. In this paper, we show that the root bark of M. alba inhibits the compound 48/80-induced systemic anaphylactic shock and anti-CGG IgE-induced rat peritoneal mast cell activations and the increased vascular permeability while cAMP level is increased. In addition, its effects are compared with disodium cromoglycate (DSCG), a known cell stabilizer which inhibits the release of pre-formed and newly synthesized chemical mediators from a variety of cells involved in allergic and inflammatory responses. 18) MATERIALS AND METHODS MaterialsCompound 48/80, bovine serum albumin (BSA), disodium cromoglycate (DSCG) and HEPES, chicken gamma globulin (CGG) were purchased from Sigma Chemical Co. (MO, U.S.A.). DSCG, an antianaphylactic agent, was used as positive control in order to compare with HEMA activity. Percoll solution was purchased from Pharmacia (Uppsala, Sweden). Anti-CGG IgE antibodies were supplied by Hern-Ku Lee works for department of immunology, Chonbuk National University Medical School.Experimental Animals Male ICR mice and SpragueDawley rats aged 8-10 weeks were purchased from Dae Han Experimental Animal Center (Daejeon, Korea...

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“…The crude organic extract was subjected to repeated columns chromatography yielding two new ceramides (1, 2) together with twenty one known compounds namely lanosta-7,24-dien-3-one (3), 8 lanosta-8,24-dien-3-one (4), 8 β-amyrine (5), 9 lupeol (6), 9 6-prenylpinocembrin (7), 10 bergapten (8), 11 chiricanine A (9), 12 genistein (10), 13 wighteone (11), 13 6-prenylapigenin (12), 14 24 The ceramide core was confirmed by long-range correlations exhibited on the HMBC spectrum between the proton at d H 7.38 and the carbonyl at d C 175.5. Moreover, the proton of oxymethine group at d H 3.47 (H-4) correlated with the carbons at d C 61.3 (C-1), 51.8 (C-2), and 75.8 (C-3) which matched with a trihydroxylamine-sphingosine in the phytoceramide skeleton.…”

Section: Resultsmentioning

confidence: 99%

Ceramides and cytotoxic constituents from Ficus glumosa Del. (Moraceae)

Nana

Sandjo

Keumedjio

et al. 2012

J. Braz. Chem. Soc.

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A investigação química da casca do caule de Ficus glumosa (Moraceae) deu origem a duas novas ceramidas (2R,7E)-2-hidróxi-N-[(2S,3S,4R)-1,3,4-trihidróxihexadecano--dihidróxiheptadec-9-eno-2-il}-2-hidróxipentacosanamida, em conjunto com vinte e um compostos conhecidos. As estruturas foram estabelecidas usando-se dados de RMN, espectrometria de massas, transformação química e por comparação com dados relatados. Vinte e um compostos foram posteriormente testados contra células de câncer de próstata PC-3 e seis deles revelaram efeito citotóxico. Dongnósido E foi o composto mais ativo, com IC 50 de 0,75 µmol L -1 contra células de câncer PC-3, enquanto o medicamento de referência doxorrubicina, apresentou IC 50 de 0.91 µmol L -1 . Este composto também demonstrou inibir o crescimento de células do câncer de fibrossarcoma HT1080 (IC 50 0,7 µmol L -1 ). Chemical investigation of the stem bark of Ficus glumosa (Moraceae) yielded two new ceramides (2R,7E)-2-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyhexadecan-2-yl]hexacos-7-enamide and (2R)-N-{(2S,3S,4R,9Z)-1-O-[(β-D-glucopyranosyl]-3,4-dihydroxyheptadec-9-en-2-yl}-2-hydroxypentacosanamide together with twenty one known compounds. The structures were established using NMR data, mass spectrometry, chemical transformation and by comparison with the reported data. Twenty one compounds were further tested against the prostate cancer PC-3 cell line and six of them revealed cytotoxic effect. Dongnoside E was the most active compound with an IC 50 0.75 µmol L -1 against the cancer cells line PC-3 while the reference drug doxorubicin displayed 0.91 µmol L -1 . This compound also proved to inhibit the cell growth of the fibrosarcoma cancer HT1080 (IC 50 0.7 µmol L -1 ).

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Prenylated chalcones and flavones from the leaves of dorstenia kameruniana

Cited by 66 publications

References 9 publications

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Inhibitory Effects of Morus alba on Compound 48/80-Induced Anaphylactic Reactions and Anti-Chicken Gamma Globulin IgE- Mediated Mast Cell Activation

Ceramides and cytotoxic constituents from Ficus glumosa Del. (Moraceae)

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