2011
DOI: 10.1590/s0100-879x2011007500109
|View full text |Cite
|
Sign up to set email alerts
|

Prenatally programmed hypertension: role of maternal diabetes

Abstract: Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of di… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
4
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(4 citation statements)
references
References 58 publications
0
4
0
Order By: Relevance
“…Studies in rats demonstrate that male but not female offspring of dams made diabetic prior to mating or on the 7th day of pregnancy are hypertensive by 2–3 months of age 1214 . Findings of these studies and others suggest changes in baroreflex sensitivity, vascular responsiveness, activity of the renin-angiotensin and NO systems and arachidonic acid metabolism may contribute to the development of hypertension in ODM 15,16 . Because gestational onset diabetes, characterized by maternal hyperglycemia during the last third of gestation, is the most common form of diabetes to affect pregnancy, our laboratory has focused on a rat model whereby maternal hyperglycemia is induced by streptozotocin at the beginning of the third and final week of gestation.…”
mentioning
confidence: 87%
“…Studies in rats demonstrate that male but not female offspring of dams made diabetic prior to mating or on the 7th day of pregnancy are hypertensive by 2–3 months of age 1214 . Findings of these studies and others suggest changes in baroreflex sensitivity, vascular responsiveness, activity of the renin-angiotensin and NO systems and arachidonic acid metabolism may contribute to the development of hypertension in ODM 15,16 . Because gestational onset diabetes, characterized by maternal hyperglycemia during the last third of gestation, is the most common form of diabetes to affect pregnancy, our laboratory has focused on a rat model whereby maternal hyperglycemia is induced by streptozotocin at the beginning of the third and final week of gestation.…”
mentioning
confidence: 87%
“…Environmental perturbations during pregnancy predispose offspring to altered vascular function, leading to hypertension [ 6 , 7 , 8 , 9 ] and cardiovascular disease later in life [ 10 ]. It is well known that the vascular tone of small arteries (i.e.…”
Section: Introductionmentioning
confidence: 99%
“…Mesenteric arteries of 3-month old CMO and DMO rats were split into 4 groups and incubated at 37°C during 24 h in 100 μL buffer containing Leibovitz medium with 10% fetal bovine serum, a mix of antibiotic-antimycotic solution (1%, 15240062, Gibco, Courtaboeuf, France), Dapi (5 μg/mL, Molecular Probes, Carlsab, USA) and either Alexa Fluor594/Cadaverine (10 μmol/L, A-30678, Invitrogen, Carlsab, USA), or (Aceti et al, 2012 ) Alexa Fluor594/Cadaverine + SNP ( 10 −3 mol/L), or (Bunt et al, 2005 ) Alexa Fluor594/Cadaverine + dithiothreitol (DTT, 2 mmol/L, 43816, Sigma, St Quentin Fallavier, France), or (Gomes and Gil, 2011 ) Alexa Fluor594/Cadaverine + DTT (2 mmol/L) + SNP (10 −3 mol/L). Vessels were mounted on Mowiol and imaged on a confocal microscope (Nikon Eclipse TE2000S).…”
Section: Methodsmentioning
confidence: 99%
“…Consequently, the relationship between in utero exposure to maternal diabetes and the incidence of cardiovascular diseases in offspring, and especially that of hypertension, has been the subject of clinical and experimental studies. Indeed, numerous works show that offspring of diabetic mothers have a higher systolic blood pressure (SBP) than offspring of control mothers (Bunt et al, 2005 ; Rocha et al, 2005 ; Wichi et al, 2005 ; Nehiri et al, 2008 ; Gomes and Gil, 2011 ; Aceti et al, 2012 ).…”
Section: Introductionmentioning
confidence: 99%