Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior

Wallace, Erin; Ni, Yu; Loftus, Christine T.; Sullivan, Alexis; Masterson, Erin E.; Szpiro, Adam A.; Day, Drew B; Robinson, Morgan; Kannan, Kurunthachalam; Tylavsky, Fran; Sathyanarayana, Sheela; Bush, Nicole R.; LeWinn, Kaja Z.; Karr, Catherine J.

doi:10.1016/j.envint.2021.107039

Cited by 16 publications

(10 citation statements)

References 82 publications

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“…For samples with concentrations below the limit of detection (LOD), the concentration was reported as the LOD/√2. Only those OH-PAH metabolites that were detected in > 70% of samples were included in the analysis, in alignment with prior studies by our group and others which have analyzed urinary metabolites of PAHS ( Freije et al 2022 ; A. L. Cathey et al 2020 ; Wallace et al 2022 ; Dobraca et al 2018 ; Loftus et al 2022 ). Cotinine was measured in maternal urine, as previously described (Ni Yu et al, 2021; Paquette et al, 2021).…”

Section: Methodsmentioning

confidence: 86%

“…Samples were processed and stored at −80 °C in the study repository of the University of Tennessee Health Science Center Department of Pathology. Detailed methods of OH-PAH measurements within this cohort have been described previously ( Freije et al 2022 ; Wallace et al 2022 ; Loftus et al 2022 ). Twelve OH-PAH metabolites were determined using a Waters Acquity I-class ultra-performance liquid chromatography system (Waters; Milford, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Prenatal exposure to PAH metabolites 1-hydroxypyrene (1-OH-PYR) and 2-naphthol was associated with decreased mental development scores ( Ha et al 2011 ). In the CANDLE cohort, 1-OH-PYR was associated with increased risk of neuro-developmental delay, and mixtures of OH-PAH metabolites were associated with lower language scores at age 2 ( Wallace et al 2022 ). Taken together, these observational studies suggest that maternal PAH exposure during pregnancy may cause alterations to the placental in-utero environment that result in perinatal complications and lasting effects on offspring into childhood.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette

Lapehn²,

Freije

et al. 2023

Environment International

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Section: Methodsmentioning

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette

Lapehn²,

Freije

et al. 2023

Environment International

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“…However, at the later study visit, CANDLE median pCRH levels rose to 360.3 pg/mL, whereas PROTECT levels stayed flat at 54.9 pg/mL. While some of this difference may be attributable to differences in the timing of the later visit (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) weeks in CANDLE vs 24-28 weeks in PROTECT), a more likely explanation is the use of enzymelinked immunosorbent assay (ELISA) to perform the assays in PROTECT as compared to RIA in CANDLE. A recent study of 169 women with a prior preterm birth compared pCRH measured both by RIA and ELISA, showed that pCRH concentrations measured by ELISA were stable across gestation, whereas the same samples assayed using RIA showed a steep rise in late pregnancy (64).…”

Section: Discussionmentioning

confidence: 99%

Prenatal polycyclic aromatic hydrocarbon (PAH) exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE pregnancy cohort

Barrett

Workman²,

Hazlehurst³

et al. 2022

Front. Endocrinol.

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Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous endocrine-disrupting combustion by-products that have been linked to preterm birth. One possible mechanism is through disruption of placental corticotropin releasing hormone (pCRH), a key hormone implicated in parturition. As an extension of recent research identifying pCRH as a potential target of endocrine disruption, we examined maternal PAH exposure in relation to pCRH in a large, diverse sample. Participants, drawn from the CANDLE cohort, part of the ECHO-PATHWAYS Consortium, completed study visits at 16-29 weeks (V1) and 22-39 weeks (V2) gestation (n=812). Seven urinary mono-hydroxylated PAH metabolites (OH-PAHs) were measured at V1 and serum pCRH at V1 and V2. Associations between individual log-transformed OH-PAHs (as well as two summed PAH measures) and log(pCRH) concentrations across visits were estimated using mixed effects models. Minimally-adjusted models included gestational age and urinary specific gravity, while fully-adjusted models also included sociodemographic characteristics. We additionally evaluated effect modification by pregnancy complications, fetal sex, and maternal childhood trauma history. We observed associations between 2-OH-Phenanthrene (2-OH-PHEN) and rate of pCRH change that persisted in fully adjusted models (β=0.0009, 0.00006, 0.0017), however, positive associations with other metabolites (most notably 3-OH-Phenanthrene and 1-Hydroxypyrene) were attenuated after adjustment for sociodemographic characteristics. Associations tended to be stronger at V1 compared to V2 and we observed no evidence of effect modification by pregnancy complications, fetal sex, or maternal childhood trauma history. In conclusion, we observed modest evidence of association between OH-PAHs, most notably 2-OH-PHEN, and pCRH in this sample. Additional research using serial measures of PAH exposure is warranted, as is investigation of alternative mechanisms that may link PAHs and timing of birth, such as inflammatory, epigenetic, or oxidative stress pathways.

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“…Population studies have found that PAH affects multiple systems such as the nervous (Feng et al 2022), cardiovascular (Mallah et al 2022), and renal (Rahman et al 2022) systems, and may lead to the occurrence of chronic diseases such as diabetes (Srivastava 2022) and hypertension (Wang et al 2022a). Moreover, the mixture toxicity of PAH with a series of compounds, is also well studied (Eriksson et al 2022, Kreutzer et al 2022, Wallace et al 2022. Few of these studies have focused on the mixed toxicity of PAH by adding HAA for analysis.…”

Section: Discussionmentioning

confidence: 99%

Association Between Urinary Heterocyclic Aromatic Amines and Mortality in Adults

Zhang

Lin

et al. 2022

Preprint

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Heterocyclic aromatic amines (HAA) are mutagenic compounds; however, their long-term effects on humans remain poorly studied. This study investigated the association between HAA concentration and mortality in adults. Data from the National Health and Nutrition Examination Survey 2013-2014 were linked to mortality data from 2019 and analyzed using Cox regression analysis to determine the association of different HAA with all-cause, cardiovascular disease (CVD), and cancer mortality. Age, sex, education level, race, poverty income ratio, body mass index, smoking status, drinking status, and serum cotinine were included as covariates in three different Cox regression models. This study included 1,713 adults with a median age of 47 years (49.5% men). During a median follow-up at 71 months, 100 deaths occurred. Owing to detection limits, only four had discernible detection rates and were included in our analysis. Among them, only norharman concentration was significantly associated with all-cause and CVD mortality. The hazard ratio (HR) was 1.50 (95% confidence interval: 1.10–2.04) for all-cause mortality when analyzing norharman concentration as a natural log-transformed continuous variable and 3.33 (95% confidence interval: 2.24–4.95) for CVD mortality. Associations remained consistent when norharman concentrations were analyzed as binary variables (split by median). Urinary harman concentration seemed to show a negative association with cancer mortality. No definitive evidence was found of an association between other HAA and mortality. Urinary norharman concentration is associated with all-cause mortality and CVD mortality in adults.

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Prenatal urinary metabolites of polycyclic aromatic hydrocarbons and toddler cognition, language, and behavior

Cited by 16 publications

References 82 publications

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Prenatal polycyclic aromatic hydrocarbon (PAH) exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE pregnancy cohort

Association Between Urinary Heterocyclic Aromatic Amines and Mortality in Adults

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