Prenatal ultrasound findings of lissencephaly associated with Miller–Dieker syndrome and comparison with pre‐ and postnatal magnetic resonance imaging

Fong, Katherine; Ghai, Sangeet; Toi, Ants; Blaser, Susan; Winsor, Elizabeth J.T.; Chitayat, David

doi:10.1002/uog.1777

Cited by 100 publications

(67 citation statements)

References 14 publications

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“…Overproduction of CSF is observed in cases of choroid plexus papilloma (Di Rocco and Iannelli, 1997;Nejat et al, 2007) thus defining a 'nonobstructive' lesion. VM can be secondary to disorders of neuronal proliferation (megalencephaly, microcephaly), neuronal migration (schizencephaly, lissencephaly), agenesis of the corpus callosum (ACC) or disorders of organogenesis, such as holoprosencephaly (Ashwal, 2001;Fong et al, 2004;Malinger et al, 2007;Pastorino et al, 2007). Finally, it can be the consequence of destructive processes of the cerebral matter, resulting from vascular insults or infections (Pilu and Hobbins, 2002;Zimmerman and Bilaniuk, 2005).…”

Section: Prenatal Definitionsmentioning

confidence: 99%

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

Gaglioti¹,

Oberto²,

Todros³

2009

Prenatal Diagnosis

134

119

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Fetal cerebral ventriculomegaly (VM) is diagnosed when the width of one or both ventricles, measured at the level of the glomus of the choroid plexus (atrium), is ≥10 mm. VM can result from different processes: abnormal turnover of the cerebrospinal fluid (CSF), neuronal migration disorders, and destructive processes. In a high percentage of cases, it is associated with structural malformations of the central nervous system (CNS), but also of other organs and systems. The rate of associated malformations is higher (≥60%) in severe VM (>15 mm) and lower (10-50%) in cases of borderline VM (10-15 mm). When malformations are not present, aneuploidies are found in 3-15% of borderline VM; the percentage is lower in severe VM. The neurodevelopmental outcome of isolated VM is normal in >90% of cases if the measurement of ventricular width is between 10 and 12 mm; it is less favorable when the measurement is >12 mm.

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Section: Prenatal Definitionsmentioning

confidence: 99%

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

Gaglioti¹,

Oberto²,

Todros³

2009

Prenatal Diagnosis

134

119

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“…Intracranial arachnoid cyst (IAC) in the quadrigeminal cistern and ventriculomegaly have been reported previously in a Lhasa Apso dog with lissencephaly [14]. Ventriculomegaly is a relatively common finding in human lissencephaly, and the possible cause was thought to be a diminished cerebral volume [3]. Previously, IAC was suspected to be of developmental origin in dogs [17].…”

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confidence: 99%

Clinical and MRI Findings of Lissencephaly in a Mixed Breed Dog

et al. 2011

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ABSTRACT. A 7-year-old castrated male mixed-breed dog was presented with a complaint of acute pain. The dog had suffered from isolated seizures for two years. Magnetic resonance imaging (MRI) of the brain revealed a smooth brain surface due to lack of gyri and sulci formation of the cerebrum and thick cortical grey matter. Additionally, ventriculomegaly and an arachnoid cyst were noted. Multiple spinal cord compressions induced by intervertebral disc protrusion were observed on a cervical MRI. Based on these findings, the dog was diagnosed as having lissencephaly concurrent with intervertebral cervical disease. After therapy for seizure and cervical pain, the clinical signs were completely resolved. To the author's knowledge, this is the case report to diagnose lissencephaly in a mixedbreed dog.

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“…rhage, known as one of the most important causes of prenatal death as well as neonatal cerebral palsy [6,7] . Therefore, a method that can provide an accurate and early diagnosis is of great need.…”

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confidence: 99%

Contribution of MRI to Detect Further Anomalies in Fetal Ventriculomegaly

Yin

Chen

et al. 2009

Fetal Diagn Ther

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Objectives: The purpose of this study was to determine the contribution of magnetic resonance imaging (MRI) in detecting further anomalies in fetal ventriculomegaly (VM). Methods: From March 2006 to March 2008, fasting MRI scanning was performed on 70 women in whom ultrasonography (US) diagnosed fetal VM at Shengjing Hospital affiliated to the China Medical University. The US and MRIs were then compared. Result: US diagnosed 41 cases of unilateral VM and 29 cases of bilateral VM; 51 cases (72.86%) being mild, 17 cases moderate and 2 cases severe VM. Eight fetuses showed additional brain hemorrhage and other anomalies on MRI. Among these 8 cases, 1 (2.44%, 1/41) had unilateral VM, whereas 7 (24.13%, 7/29) had bilateral VM (Fisher’s exact test, p = 0.007). On the other hand, 2 of 8 cases (25%) had mild VM, whereas 6 of 8 cases (75%) had moderate/severe VM (Fisher’s exact test, p = 0.002). Conclusion: MRI mainly modified the US diagnoses when the fetus had bilateral VM or moderate/severe VM. The most common additional diagnosis was brain hemorrhage.

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Prenatal ultrasound findings of lissencephaly associated with Miller–Dieker syndrome and comparison with pre‐ and postnatal magnetic resonance imaging

Abstract: Objective To report on the prenatal ultrasound findings in fetuses with lissencephaly associated with Miller-Dieker syndrome (MDS) and to compare these findings with those of magnetic resonance imaging (MRI). Methods

Cited by 100 publications

References 14 publications

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

The significance of fetal ventriculomegaly: etiology, short‐ and long‐term outcomes

Clinical and MRI Findings of Lissencephaly in a Mixed Breed Dog

Contribution of MRI to Detect Further Anomalies in Fetal Ventriculomegaly

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