Prenatal Ultrasound Detection of Mirror Twins With a Fused Proximal Umbilical Cord

Kütük, Mehmet Serdar; Şahin, Nurhan; Takmaz, Taha

doi:10.1002/jum.15160

Cited by 1 publication

(1 citation statement)

References 10 publications

(16 reference statements)

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“…The question remains if this is also the case in conjoined twins, where there is one duplicated entity within a single amniotic sac and single umbilical cord. From this perspective, forked umbilical cords in monoamniotic twins with growth discordances [99] and mirror-image anomalies [100] are-to say the least-quite intriguing. As it is assumed that conjoined twinning lies on the same etiological horizon as MZ twins, one could argue that MZ twinning should be interpreted as a congenital anomaly in itself in which concomitant (discordant) anomalies are potentially causally related to different phenotypical patterns in conjoined twins.…”

Section: The Twinning Dogma and The Occurrence Of Structural (Discord...mentioning

confidence: 99%

Phenotypically Discordant Anomalies in Conjoined Twins: Quirks of Nature Governed by Molecular Pathways?

Boer,

Winter,

Gorissen

et al. 2023

Diagnostics

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A multitude of additional anomalies can be observed in virtually all types of symmetrical conjoined twins. These concomitant defects can be divided into different dysmorphological patterns. Some of these patterns reveal their etiological origin through their topographical location. The so-called shared anomalies are traceable to embryological adjustments and directly linked to the conjoined-twinning mechanism itself, inherently located within the boundaries of the coalescence area. In contrast, discordant patterns are anomalies present in only one of the twin members, intrinsically distant from the area of union. These dysmorphological entities are much more difficult to place in a developmental perspective, as it is presumed that conjoined twins share identical intra-uterine environments and intra-embryonic molecular and genetic footprints. However, their existence testifies that certain developmental fields and their respective developmental pathways take different routes in members of conjoined twins. This observation remains a poorly understood phenomenon. This article describes 69 cases of external discordant patterns within different types of otherwise symmetrical mono-umbilical conjoined twins and places them in a developmental perspective and a molecular framework. Gaining insights into the phenotypes and underlying (biochemical) mechanisms could potentially pave the way and generate novel etiological visions in the formation of conjoined twins itself.

show abstract

Section: The Twinning Dogma and The Occurrence Of Structural (Discord...mentioning

confidence: 99%

Phenotypically Discordant Anomalies in Conjoined Twins: Quirks of Nature Governed by Molecular Pathways?

Boer,

Winter,

Gorissen

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

Prenatal Ultrasound Detection of Mirror Twins With a Fused Proximal Umbilical Cord

Cited by 1 publication

References 10 publications

Phenotypically Discordant Anomalies in Conjoined Twins: Quirks of Nature Governed by Molecular Pathways?

Phenotypically Discordant Anomalies in Conjoined Twins: Quirks of Nature Governed by Molecular Pathways?

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