Prenatal ultrasonic diagnosis of obstructive bowel disease: A retrospective analysis

Abstract

Fetal obstructive bowel disease was diagnosed in 29 patients at 22-37 weeks (median 32 weeks) of gestation, seven (24 per cent) of whom also displayed other anomalies. Polyhydramnios was present in 20/29 cases (69 per cent). An abnormal karyotype existed in 7/29 cases (24 per cent), of which six were diagnosed prenatally (trisomy 21, n = 5; 69,XXX, n = 1) and one postnatally (trisomy 21). There was always an association with the ultrasonic 'double bubble' sign. Obstructive bowel disease was confirmed postnatally in 20/29 (69 per cent) cases, i.e., oesophageal atresia (n = 1), duodenal obstruction (n = 12), and small bowel obstruction (n = 7). Other anomalies existed in 6/29 (21 per cent) cases, i.e., multicystic kidney (n = 1) and multiple congenital anomalies (n = 5). The perinatal mortality rate was 35 per cent (7/20).

Solution Structure of Quinoline‐ and Pyridine‐Derived Oligoamide Foldamers

“…There was no significant difference in perinatal outcome between the prenatally diagnosed isolated and non‐isolated subsets except for the high incidence of intrauterine and neonatal death in the non‐isolated subset. This is in agreement with previous studies in which intrauterine death has been reported in non‐isolated DO32, 33. Brantberg et al , however, described two cases of intrauterine death occurring in isolated DO7.…”

Application of noninvasive prenatal testing in pregnancies with fetal double bubble sign: Is it feasible?

“…The survival rate was 91.3% in our study, whereas it was 66% of prenatal cases in a previous report, in which 21 out of 29 (72.4%) prenatal cases had associated anomalies . Polyhydramnios was in 54.3% of pregnancies in our study, less common than 69% (20/29) and 75% (12/16) in other 2 studies, respectively . Accordingly, preterm birth was less frequent (39.3%) in our patients compared with that (72.%; 8/11) reported by Cohen‐Overbeek et al We believe that NIPT as an alternative to diagnostic testing would result in a substantially decreased number of invasive sample procedures.…”

“…18 Polyhydramnios was in 54.3% of pregnancies in our study, less common than 69% (20/29) and 75% (12/16) in other 2 studies, respectively. 19,20 Accordingly, preterm birth was less frequent (39.3%) in our patients compared with that (72.%; 8/11) reported by Cohen-Overbeek et al 21 We believe that NIPT as an alternative to diagnostic testing would result in a substantially decreased number of invasive sample procedures. Some cases with preterm labor induced by invasive procedures would be saved.…”

Transient Bowel Ischaemia of the Fetus

“…At sonography, overt dilatation of the fetal bowel loops is generally a sign of anatomic obstruction [5,6] . We herein report 2 cases in which dilatation of the fetal bowel was not associated to anatomic obstruction but was apparently caused by paralytic ileum.…”