Prenatal Triclosan Exposure and Anthropometric Measures Including Anogenital Distance in Danish Infants

Lassen, Tina Harmer; Frederiksen, Hanne; Kyhl, Henriette Boye; Swan, Shanna H.; Main, Katharina M.; Andersson, Anna‐Maria; Lind, Dorte Vesterholm; Husby, Steffen; Wohlfahrt-Veje, Christine; Skakkebæk, Niels E.; Jensen, Tina Kold

doi:10.1289/ehp.1409637

Cited by 80 publications

(48 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the significant association between prenatal TCS and head circumference in the Lassen et al (2016) study was observed in boys, but not girls; the two other studies limited to boys (Philippat et al , 2014 reported null results, as did the two studies that examined boys and girls together Geer et al 2017).…”

Section: Birth Outcomesmentioning

confidence: 87%

“…Tier 2 included 13 publications. Twelve of those publications (Wolff et al , 2010(Wolff et al , 2015Philippat et al 2012Philippat et al , 2014Watkins et al 2015;Aker et al 2016;Ashley-Martin et al 2016;Buckley et al 2016;Lassen et al 2016;Smarr et al 2017;Geer et al 2017) were based on seven different cohorts assembled in France, Puerto Rico, Denmark, Canada, and various parts of the US. One paper ) presented a case-control study that used incident cases identified among members of a French cohort.…”

Section: Methodsmentioning

confidence: 99%

“…Of the 43 studies, 24 were conducted in North America (Wolff et al , 2010(Wolff et al , 2015Clayton et al 2011;You et al 2011;Buttke et al 2012;Savage et al 2012Savage et al , 2014Koeppe et al 2013;Lankester et al 2013;Buser et al 2014;Spanier et al 2014;Adgent and Rogan 2015;Li et al 2015;Ihde et al 2015;Shiue 2015aShiue , 2015bVelez et al 2015;Ashley-Martin et al 2016;Buckley et al 2016;Poole et al 2016;Scinicariello and Buser 2016;Smarr et al 2017;Geer et al 2017), two studies in the Caribbean (Watkins et al 2015;Aker et al 2016), 10 studies in Europe (Allmyr et al 2009;Chevrier et al 2012;Philippat et al 2012Philippat et al , 2014Bertelsen et al 2013;Buhl et al 2014;Den Hond et al 2013, 2015Geens et al 2015;Lassen et al 2016), four in Asia (Chen et al 2013;Wang et al 2015;Xue et al 2015;Zhu et al 2016), and three in Australia (Cullinan et al 2012(Cullinan et al , 2015a…”

Section: Overview Of Studiesmentioning

confidence: 99%

“…For example, Wolff et al (2008) and Geer et al (2017) reported the associations between prenatal TCS and birth weight in boys and girls adjusted for sex, Philippat et al (2012) and Philippat et al (2014) excluded girls from their analyses, and Lassen et al (2016) reported findings separately for boys and girls.…”

Section: Birth Outcomesmentioning

confidence: 99%

“…For example, Lassen et al (2016) recruited women into their study starting in January 2010 and some samples were not analyzed until December 2012. No information was given on the length of time the samples were maintained at room temperature or whether any assessment of analyte stability was conducted in order to ascertain that two years is an acceptable storage time.…”

Section: Exposure Assessmentmentioning

confidence: 99%

See 4 more Smart Citations

Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

View full text Add to dashboard Cite

The ability of epidemiologic evidence to inform regulatory decisions is largely dependent on the coherence and quality of the published literature. This systematic review examines the quality and consistency of studies assessing health outcomes associated with exposure to triclosan (TCS), an antimicrobial chemical with a short physiologic half-life. We used elements of the Biomonitoring, Environmental Epidemiology, and Short-Lived Chemicals instrument to evaluate aspects of study quality. Each methodological domain -overall design, exposure assessment, and data analysis -was categorized according to three tiers where Tier 1 indicated the highest quality. We also examined consistency of methods, results and reporting as considerations for weight of evidence (WOE) assessment. Studies were considered sufficiently comparable if they addressed the same or similar research questions. Forty-two studies met the criteria for inclusion. Only one randomized cross-over clinical trial of TCS was assigned to Tier 1 for all three domains. Most other studies were assigned to Tier 3 for at least one domain. Although the available literature examined more than 100 different health endpoints and reported hundreds of different measures of association, few studies were considered comparable. For reported measures of association, most were not significantly different from the null; the few statistically significant results represented isolated findings without a discernable across-or within-study pattern. We conclude that the current body of epidemiologic literature does not allow a meaningful WOE assessment due to methodological limitations of individual studies and lack of inter-study consistency. On the other hand, methodologically stronger studies may be used to inform future research. ARTICLE HISTORY

show abstract

Section: Birth Outcomesmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Overview Of Studiesmentioning

confidence: 99%

Section: Birth Outcomesmentioning

confidence: 99%

Section: Exposure Assessmentmentioning

confidence: 99%

See 3 more Smart Citations

Systematic review of the literature on triclosan and health outcomes in humans

Goodman

Naiman

LaKind

2017

Critical Reviews in Toxicology

View full text Add to dashboard Cite

show abstract

Developmental toxicity induced by triclosan exposure in zebrafish embryos

Iannetta

Caioni

Vito

et al. 2022

Birth Defects Research

View full text Add to dashboard Cite

Objectives: The present study aimed to investigate the acute toxicity and the developmental alterations induced by triclosan (TCS) exposure in zebrafish early-life stages using fish embryo acute toxicity tests as a methodological approach.Material and Methods: Zebrafish embryos were exposed to five concentrations of TCS and the four lethal alterations were daily recorded to determine the toxicological endpoints of acute toxicity. Furthermore, sublethal alterations were recorded to assess the effect of exposure concentrations on zebrafish embryo's development.Results: The TCS toxicity was determined at 96 h of exposure as lethal concentration 10, lethal concentration 20, lethal concentration 50, lowest observed effects concentration, and no observed effects concentration, reported the following values: 168, 197.2, 267.8, 300, and 200 μg/L. Exposed larvae showed a delay in hatching rate and developed sublethal alterations including reduced blood flow, pericardial oedemata, reduced heartbeat, blood congestion, and craniofacial malformations. The number of zebrafish larvae developing cardiovascular alterations changed according to the tested concentrations and time of evaluation. Conclusion:The data confirmed the developmental toxicity of TCS on aquatic organisms and the sublethal alterations developed by zebrafish larvae, indicated its cardiotoxicity and neurotoxicity. Moreover, the developmental toxicity was strongly influenced by the concentration tested and the number of survived zebrafish developing this alteration varying according to the time of exposure. K E Y W O R D S aquatic toxicology, in vivo model, personal care products toxicity, sublethal alterations 1 | INTRODUCTION Triclosan (5-chloro-2-(2,4-dichloro phenoxy)phenol; TCS) is a nonionic, broad-spectrum antimicrobial used as ingredient in disinfectants, soap, detergent, toothpaste, mouthwash, fabric, deodorant, shampoo, and plastic additives, in addition to innumerable other personal care, veterinary, industrial, and household products (Dann &

show abstract

Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders

et al. 2018

View full text Add to dashboard Cite

Male reproductive development is intricately dependent on fetal androgen action. Consequently, disrupted androgen action during fetal life can interfere with the development of the reproductive system resulting in adverse effects on reproductive function later in life. One biomarker used to evaluate fetal androgen action is the anogenital distance (AGD), the distance between the anus and the external genitalia. A short male AGD is strongly associated with genital malformations at birth and reproductive disorders in adulthood. AGD is therefore used as an effect readout in rodent toxicity studies aimed at testing compounds for endocrine activity and anti-androgenic properties, and in human epidemiological studies to correlate fetal exposure to endocrine disrupting chemicals to feminization of newborn boys. In this review, we have synthesized current data related to intrauterine exposure to xenobiotics and AGD measurements. We discuss the utility of AGD as a retrospective marker of in utero anti-androgenicity and as a predictive marker for male reproductive disorders, both with respect to human health and rodent toxicity studies. Finally, we highlight four areas that need addressing to fully evaluate AGD as a biomarker in both a regulatory and clinical setting.

show abstract

Prenatal Triclosan Exposure and Anthropometric Measures Including Anogenital Distance in Danish Infants

Cited by 80 publications

References 51 publications

Systematic review of the literature on triclosan and health outcomes in humans

Systematic review of the literature on triclosan and health outcomes in humans

Developmental toxicity induced by triclosan exposure in zebrafish embryos

Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders

Contact Info

Product

Resources

About