Prenatal tobacco smoke exposure, risk of schizophrenia, and severity of positive/negative symptoms

Σταθοπούλου, Αναστασία; Beratis, Ion; Beratis, Stavroula

doi:10.1016/j.schres.2013.04.031

Cited by 26 publications

(23 citation statements)

References 49 publications

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“…This is consistent with limited prior studies indicating that PEMS may elevate risk for psychotic symptoms/disorders (Spauwen et al, 2004; Zammit et al, 2009; Ekblad et al, 2010). We found a lower severity of deficit symptoms, which is inconsistent with the prior report indicating that PEMS was associated with greater negative symptom severity (Stathopoulou et al, 2013). …”

contrasting

confidence: 99%

“…PEMS could conceivably impact illness manifestation among individuals with psychotic disorders. Smith et al (2010) showed no association with symptom type or severity, or with symptom change across one year, among first-episode psychosis (FEP) patients, but Stathopoulou et al (2013) found that PEMS was related to greater severity of negative symptoms.…”

mentioning

confidence: 99%

“…Although one study did not demonstrate a link between PEMS and risk for schizophrenia (Baguelin-Pinaud et al, 2010), Stathopoulou et al (2013) found that prenatal tobacco exposure was independently associated with a later schizophrenia diagnosis. Ekblad et al (2010) reported that the exposure is associated with increased risk of psychiatric morbidity including broadly defined psychosis.…”

mentioning

confidence: 99%

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Prenatal exposure to maternal smoking and symptom severity among offspring with first-episode nonaffective psychosis

Bernardini

Wan

Crisafio

et al. 2015

Schizophrenia Research

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Prenatal exposure to maternal smoking and symptom severity among offspring with first-episode nonaffective psychosis

Bernardini

Wan

Crisafio

et al. 2015

Schizophrenia Research

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“…While one study had found prenatal maternal smoking to be strongly correlated with increased tic severity, this may have been confounded by not taking SES into account (Mathews et al, 2006). Also in other neurodevelopmental disorders in which a role for maternal smoking had been implicated (Hultman et al, 2002; Kalkbrenner et al, 2012; Stathopoulou et al, 2013), studies conducted with larger sample sizes or with appropriate correction for confounding factors such as SES did not confirm an effect of smoking (Cannon et al, 2002; Knopik, 2009; Larsson et al, 2005; Lee et al, 2012). Still, there may be an effect of heavy maternal smoking (>10 cigarettes per day) on co-occurring ADHD (Motlagh et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Abdulkadir

Tischfield

King

et al. 2016

Journal of Psychiatric Research

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Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1,113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR=1.72) and morning sickness requiring medical attention (OR=2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR=1.07). Furthermore, neonatal complications were related to the presence (OR=1.46) and severity (b=2.27) of co-occurring OCD and also to ADHD severity (b=1.09). Delivery complications were only related to co-occurring OCD (OR=1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

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“…We identified a priori several potential maternal/paternal, socioeconomic and offspring confounding variables based on previous literature in this area: mother's age at delivery, maternal education level, maternal social class, marital status, low income, maternal history of depression, exposure to influenza, use of cannabis, alcohol and illicit drugs during pregnancy, offspring sex, birth weight and gestation at delivery [10,11].…”

Section: Confounding Variablesmentioning

confidence: 99%

Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort study

et al. 2017

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Objectives Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood.Methods We used data on 2,957 participants from a large birth cohort (Avon Longitudinal Study of Parents and Children, ALSPAC). The primary outcome of interest was hypomania, and the secondary outcome was 'hypomania plus previous psychotic experiences (PE)'. Maternally-reported smoking during pregnancy, paternal smoking and exposure to environmental tobacco smoke (ETS) in childhood were the exposures of interest. Multivariable logistic regression was used and estimates of association were adjusted for socio-economic, lifestyle and obstetric factors.Results There was weak evidence of an association between exposure to maternal smoking in utero and lifetime hypomania. However, there was a strong association of maternal smoking during pregnancy within the sub-group of individuals with hypomania who had also experienced psychotic symptoms (OR = 3·45, 95%CI 1·49=7·98, P = 0·004). There was no association between paternal smoking, or exposure to ETS during childhood, and hypomania outcomes. ConclusionsExposure to smoking in utero may be a risk factor for more severe forms of psychopathology on the mood-psychosis spectrum, rather than DSM-defined bipolar disorder.

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Prenatal tobacco smoke exposure, risk of schizophrenia, and severity of positive/negative symptoms

Cited by 26 publications

References 49 publications

Prenatal exposure to maternal smoking and symptom severity among offspring with first-episode nonaffective psychosis

Prenatal exposure to maternal smoking and symptom severity among offspring with first-episode nonaffective psychosis

Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Exposure to tobacco smoke in utero or during early childhood and risk of hypomania: Prospective birth cohort study

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