Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex

Szymańska, Magdalena; Suska, Anna; Budziszewska, Bogusława; Jaworska-Feil, L; Basta‐Kaim, Agnieszka; Leśkiewicz, Monika; Kubera, Marta; Gergont, Aleksandra; Kroczka, Sławomir; Kaciński, Marek; Lasoń, Władysław

doi:10.1016/s1734-1140(09)70113-6

Cited by 31 publications

(27 citation statements)

References 41 publications

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“…Prenatal stress is one of the well-characterized animal models of depression, and the face, predictive and construct validities of this model have previously been reported [8,25,28,29,32,33,34]. In addition to depression-like behavioral changes, hyperactivity of the HPA axis and increases in blood glucose levels were observed in this model.…”

Section: Discussionmentioning

confidence: 58%

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

et al. 2014

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Introduction: Recent data indicate that there is a link between depression and diabetes and that excess glucocorticoids may play an underlying role in the pathogenesis of both of these diseases. The aim of the present study was to determine whether there are any alterations in glucose, glycogen, glucose transporters, insulin, insulin receptors or corticosterone concentrations in the hippocampus and frontal cortex in a prenatal stress rat model of depression. Methods: Male rats whose mothers had been subjected to stress and control animals were subjected to the Porsolt test to verify the experimental model. Next, some of the rats were subjected to acute stress and/or were administered glucose. Glucose, glycogen, corticosterone, insulin, insulin receptor, phospho-insulin receptor and glucose transporter (GLUT1, GLUT3 and GLUT4) concentrations were assayed. Results: Prenatally stressed rats exhibited glucose and glycogen concentrations in both investigated brain structures that exceeded those of the control animals. Prenatal stress also increased the levels of glucose transporters - GLUT1 in both tissues and GLUT4 in the frontal cortex. The changes in the prenatally stressed rats were more prominent in the animals that were subjected to stress or glucose loading in adulthood. Conclusion: The increase in carbohydrate brain concentrations evoked by prenatal stress may result from changes in the amounts of glucose transporters, especially GLUT1. Moreover, the obtained results support the hypothesis that stress during the perinatal period permanently increases the sensitivity of brain tissue to factors that act in adulthood.

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Section: Discussionmentioning

confidence: 58%

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

et al. 2014

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“…Mice overexpressing GSK-3β shows prodepressant-like phenotype and increased sensitivity to chronic mild stress; these behaviour changes can be prevented by chronic, but not by acute treatment with fluoxetine (Zhang et al 2013). In prenatally stressed rats GSK-3β levels were significantly elevated in the frontal cortex, but not in the hippocampus (Szymańska et al 2009), while concentration of phosphorylated GSK-3β was decreased only in the former structure. Chronic treatment with antidepressant drugs diminished stress-induced alterations in GSK-3β and phospho-GSK-3β only in the frontal cortex (Szymańska et al 2009).…”

Section: Discussionmentioning

confidence: 94%

“…In prenatally stressed rats GSK-3β levels were significantly elevated in the frontal cortex, but not in the hippocampus (Szymańska et al 2009), while concentration of phosphorylated GSK-3β was decreased only in the former structure. Chronic treatment with antidepressant drugs diminished stress-induced alterations in GSK-3β and phospho-GSK-3β only in the frontal cortex (Szymańska et al 2009). In addition, chronic treatment with citalopram alleviated the depression-like behaviors and reversed the decrease of the phosphorylated GSK-3β in stressed rats (Liu et al 2012).…”

Section: Discussionmentioning

confidence: 94%

“…Increase in GSK-3β activity results from up-regulation of GSK-3β gene expression or down-regulation of GSK-3β phosphorylation and hence decrease in the ratio between phosphorylated GSK-3β and total GSK-3β. Evidence for the involvement of GSK-3β in major depression is obtained from both animal models (Szymańska et al 2009) and depressed patients (Pláteník et al 2014). Increase in GSK-3β activity in depressed animals can be reversed by treatment with SSRIs.…”

Section: Discussionmentioning

confidence: 99%

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Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine

Bai

Song

et al. 2017

Psychopharmacology

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Here we present the data indicating that chronic treatment with fluoxetine regulates Cav-1/PTEN/PI3K/AKT/GSK-3β signalling pathway and glycogen content in primary cultures of astrocytes with bi-phasic concentration dependence. At lower concentrations fluoxetine down-regulates gene expression of Cav-1, decreases membrane content of PTEN, increases activity of PI3K/AKT, and elevates GSK-3β phosphorylation thus suppressing its activity. At higher concentrations fluoxetine acts in an inverse fashion. As expected, fluoxetine at lower concentrations increased while at higher concentrations decreased glycogen content in astrocytes. Our findings indicate that bi-phasic regulation of glycogen content via Cav-1/PTEN/AKT/GSK-3β pathway by fluoxetine may be responsible for both therapeutic and side effects of the drug.

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“…Patients with schizophrenia spectrum had a larger pituitary volume (larger in female than male patients), reflecting hyperactivity of the HPA axis, which may be related to a common vulnerability to stress in patients [63]. Dysregulation of HPA axis activity can be detected not only in depressed but also in schizophrenic patients [64,65], and the hypothesis of HPA axis hyperactivity in schizophrenia was supported by an experiment using a neurodevelopmental model of schizophrenia in rats [66]. HPA axis activity is associated with the severity of multiple types of symptoms in first-episode psychosis, and patients' diagnosis and clinical phase partially influence these associations [67].…”

Section: Hypothalamusmentioning

confidence: 99%

Females with schizophrenia have abnormal functional cortical connectivity in the gamma frequency during an auditory oddball task using magnetoencephalography

Fujimoto¹,

Okumura²,

Takeuchi³

et al. 2014

OJPsych

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We studied differences in imaginary coherence (IC) of the gamma band between brain regions of female schizophrenia patients during the auditory oddball task using magnetoencephalography (MEG). Subjects were 12 right-handed female schizophrenia patients, who were evaluated by the Positive and Negative Syndrome Scales (PANSS). Functional connectivity during an auditory oddball task was reconstructed in low gamma (30 -50 Hz) and high gamma (50 -100 Hz and 100 -150 Hz) bands, and represented by IC using seeds determined by the significant oscillatory power changes obtained by event-related synchronization (ERS) and event-related desynchronization (ERD) power measurements. Gamma ERS (30 -50 Hz) power was decreased in the left precuneus at 500 -750 ms and in the right precuneus at 750 -1000 ms. IC in the gamma band (50 -100 Hz) was decreased between the right precuneus (seed) and right paracentral lobule (target) and between the right precuneus and right hypothalamus at 0 -250 ms. IC in the gamma band (100 -150 Hz) was increased between the left precuneus and right cuneus (Brodmann area 7) at 250 -500 ms, between the left precuneus and right culmen at 500 -750 ms, and between the left precuneus and right cuneus (Brodmann area 17), between the left precuneus and right posterior cingulate cortex, and between the left precuneus and right caudate nucleus at 750 -1000 ms. In the high gamma band (50 -100 Hz) at 0 -250 ms, significant positive correlations were shown between IC and conceptual disorganization in PANSS scores, between IC and unusual thought content score, and between IC and positive scale score. IC within the high gamma band in female schizophrenia patients showed two types of functional disconnection, intrahemispheric and interhemispheric. IC between the right or left precuneus and other specific cortical areas showed dysfunction, suggesting that the parietal lobe plays an important role in dysfunction in connectivity in the gamma band during the oddball task.

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Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex

Cited by 31 publications

References 41 publications

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

Elevated Brain Glucose and Glycogen Concentrations in an Animal Model of Depression

Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine

Females with schizophrenia have abnormal functional cortical connectivity in the gamma frequency during an auditory oddball task using magnetoencephalography

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