Prenatal stress and offspring depression in adulthood: The mediating role of childhood trauma

Liu, Yiwen; Heron, Jon; Hickman, Matthew; Zammit, Stanley; Wolke, Dieter

doi:10.1016/j.jad.2021.10.019

Cited by 12 publications

(5 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These associations may be particularly vulnerable to unobserved confounding and se lection effects, most importantly by maternal mental health and behaviour. Cyclical relationships between poor perinatal men tal health, social adversity, maternal stress, maternal behaviour (in cluding alcohol and substance use), maternal care and prena tal nutrition 83 may lead to a sociodevelopmental cascade that in creases exposure to adverse child outcomes (all of which have been associated with risk of mental disorders), including early life infec tions (with a stronger relationship between some infections and psychosis 68 rather than depression 84 ), obstetric complications 68,85 , altered neurodevelopment 86 , childhood adversities 87 , and behav ioural and mental health difficulties 88 . If proven, this would warrant public mental health strategies focused on improving prenatal ma ternal, parental and familial conditions as an intervention strategy that could benefit multiple parentchild outcomes.…”

Section: Early Life Adversitymentioning

confidence: 99%

The social determinants of mental health and disorder: evidence, prevention and recommendations

Kirkbride,

Anglin,

Colman

et al. 2024

World Psychiatry

View full text Add to dashboard Cite

People exposed to more unfavourable social circumstances are more vulnerable to poor mental health over their life course, in ways that are often determined by structural factors which generate and perpetuate intergenerational cycles of disadvantage and poor health. Addressing these challenges is an imperative matter of social justice. In this paper we provide a roadmap to address the social determinants that cause mental ill health. Relying as far as possible on high‐quality evidence, we first map out the literature that supports a causal link between social determinants and later mental health outcomes. Given the breadth of this topic, we focus on the most pervasive social determinants across the life course, and those that are common across major mental disorders. We draw primarily on the available evidence from the Global North, acknowledging that other global contexts will face both similar and unique sets of social determinants that will require equitable attention. Much of our evidence focuses on mental health in groups who are marginalized, and thus often exposed to a multitude of intersecting social risk factors. These groups include refugees, asylum seekers and displaced persons, as well as ethnoracial minoritized groups; lesbian, gay, bisexual, transgender and queer (LGBTQ+) groups; and those living in poverty. We then introduce a preventive framework for conceptualizing the link between social determinants and mental health and disorder, which can guide much needed primary prevention strategies capable of reducing inequalities and improving population mental health. Following this, we provide a review of the evidence concerning candidate preventive strategies to intervene on social determinants of mental health. These interventions fall broadly within the scope of universal, selected and indicated primary prevention strategies, but we also briefly review important secondary and tertiary strategies to promote recovery in those with existing mental disorders. Finally, we provide seven key recommendations, framed around social justice, which constitute a roadmap for action in research, policy and public health. Adoption of these recommendations would provide an opportunity to advance efforts to intervene on modifiable social determinants that affect population mental health.

show abstract

Section: Early Life Adversitymentioning

confidence: 99%

The social determinants of mental health and disorder: evidence, prevention and recommendations

Kirkbride,

Anglin,

Colman

et al. 2024

World Psychiatry

View full text Add to dashboard Cite

show abstract

“…Any deviation from this sequence may potentially alter brain formation and functions and therefore precipitate pathological conditions that often do not manifest until later in life. Accordingly, perinatal stress consequences have been observed in the offspring only at adulthood both in preclinical and clinical settings − and the same occurs after other types of manipulations such as prenatal infection. − In line, it is possible to hypothesize that, despite the latency in the manifestation of the pathological conditions, molecular alterations may be already present but remain below threshold, leading to increased vulnerability and an inability to cope with a subsequent challenging event.…”

Section: Introductionmentioning

confidence: 97%

Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress

Gallo,

Dolci,

Fumagalli

et al. 2024

ACS Chem. Neurosci.

View full text Add to dashboard Cite

Any deviation from the programmed processes of brain development may modify its formation and functions, thereby precipitating pathological conditions, which often become manifest in adulthood. Exposure to a challenge during crucial periods of vulnerability, such as adolescence, may reveal molecular changes preceding behavioral outcomes. Based on a previous study showing that prenatal fluoxetine (FLX) leads to the development of an anhedonic-like behavior in adult rats, we aimed to assess whether the same treatment regimen (i.e., fluoxetine during gestation; 15 mg/kg/day) influences the ability to respond to acute restraint stress (ARS) during adolescence. We subjected the rats to a battery of behavioral tests evaluating the development of various phenotypes (cognitive deficit, anhedonia, and anxiety). Furthermore, we carried out molecular analyses in the plasma and prefrontal cortex, a brain region involved in stress response, and whose functions are commonly altered in neuropsychiatric conditions. Our findings confirm that prenatal manipulation did not affect behavior in adolescent rats but impaired the capability to respond properly to ARS. Indeed, we observed changes in several molecular key players of the hypothalamic pituitary adrenal axis, particularly influencing genomic effects mediated by the glucocorticoid receptor. This study highlights that prenatal FLX exposure influences the ability of adolescent male rats to respond to an acute challenge, thereby altering the functionality of the hypothalamic-pituitary-adrenal axis, and indicates that the prenatal manipulation may prime the response to challenging events during this critical period of life.

show abstract

“…This study aims to investigate whether stress assessed by maternal psychometrics, socioeconomic status and glucocorticoids affects fetal BDNF measurements in amniotic fluid at birth. Besides depression and anxiety ( Deuschle et al, 2018 ), childhood trauma, low prenatal attachment to the unborn ( Liu et al, 2022 ; Şanlı and Aypar Akbağ, 2022 ), low social support and low socioeconomic status ( Bedaso et al, 2021 ), relate to high maternal stress and are therefore investigated in this study to assess stress during pregnancy. Additionally, the sum of cortisol and cortisone in amniotic fluid represents the overall glucocorticoid load in the amniotic fluid within the direct environment of the fetus ( Beitins et al, 1973 ; Stirrat et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Stress in pregnancy - Implications for fetal BDNF in amniotic fluid at birth

Lamadé,

Pedraz-Petrozzi,

Lindner

et al. 2024

Neurobiology of Stress

View full text Add to dashboard Cite

Prenatal stress and offspring depression in adulthood: The mediating role of childhood trauma

Cited by 12 publications

References 63 publications

The social determinants of mental health and disorder: evidence, prevention and recommendations

The social determinants of mental health and disorder: evidence, prevention and recommendations

Prenatal Fluoxetine Exposure Influences Glucocorticoid Receptor-Mediated Activity in the Prefrontal Cortex of Adolescent Rats Exposed to Acute Stress

Stress in pregnancy - Implications for fetal BDNF in amniotic fluid at birth

Contact Info

Product

Resources

About