Prenatal sonographic diagnosis of single umbilical artery

Wu, Meng Hsing; Chang, Feng-Cheng; Shen, Meng‐Ru; Yao, Bor Lin; Chang, Cheng-Yen; Chen, Yu; Hsu, Chao Chin; Huang, Kuo Yuan

doi:10.1002/(sici)1097-0096(199710)25:8<425::aid-jcu3>3.0.co;2-l

Cited by 21 publications

(11 citation statements)

References 13 publications

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“…Owing to the lack of population‐based studies, we summarized the results of case series on aneuploidy in iSUA fetuses (Table 1). Among 695 iSUA cases reported on in 16 studies, there were four cases of aneuploidy (0.58%). The average maternal age in these studies was 30.1 years.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta‐analysis

Voskamp

Fleurke‐Rozema

Oude-Rengerink

et al. 2013

Ultrasound in Obstet & Gyne

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Section: Resultsmentioning

confidence: 99%

“…Therefore there is no certainty about the true number of iSUAs. As the reported specificity of prenatal ultrasound in detecting SUA is high (average 98.9 (range, 93.4–100.0)%), it is unlikely that TVC fetuses in the SUA group positively biased the outcome findings.…”

Section: Discussionmentioning

confidence: 99%

Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta‐analysis

Voskamp

Fleurke‐Rozema

Oude-Rengerink

et al. 2013

Ultrasound in Obstet & Gyne

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“…The literature includes conflicting recommendations regarding management when SUA is recognized prenatally. 1,3,4,[11][12][13][14][15][16] There is general agreement that targeted ultrasound, if not already done, is indicated due to the high incidence of associated anomalies, 1,3,4,13,15,16 but many believe that if no other anomalies are detected on ultrasound, further testing is unnecessary.…”

Section: Resultsmentioning

confidence: 99%

Single umbilical artery: What does it mean for the fetus? A case-control analysis of pathologically ascertained cases

Prucka

Clemens

Craven

et al. 2004

Genetics in Medicine

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Purpose: To ascertain the frequency of chromosomal and other anomalies in fetuses with single umbilical artery.Methods: Placentas with single umbilical artery were identified from hospital pathology laboratory records. For each identified case, the next consecutive placenta with two umbilical arteries served as a control. Pathology records, maternal histories, and prenatal ultrasounds when available were reviewed for congenital anomalies, pregnancy complications, and maternal characteristics. When indicated, placental specimens, amniocytes, or neonatal bloods were karyotyped. Results: Single umbilical artery existed in 2.0% (97/4846) of pathological specimens.Fetuses with single umbilical artery had significantly more chromosomal (10.3% vs. 1.0%) and other congenital anomalies (27% vs. 8%). Conclusions: The high incidence of major chromosomal and congenital anomalies justifies detailed fetal ultrasonography, echocardiography, and amniocentesis for karyotype when single umbilical artery is discovered during routine ultrasound. Genet Med 2004:6(1):54 -57. Key Words: single umbilical artery, chromosome anomalies, detailed ultrasound, karyotype, fetal echocardiographyThe umbilical cord forms between 13 and 38 days after conception and normally serves as the conduit for two umbilical arteries and one umbilical vein. 1,2 In some cases only a single umbilical artery (SUA) is present. Some report that this umbilical abnormality can be observed as early as 13 weeks. However, it is typically diagnosed in the third trimester. 1,3 There are three theories to explain how a SUA may form during development. 1,4 The first is that a primary agenesis of one umbilical artery results in a SUA. Another theory attributes the phenomenon to a secondary atrophy or atresia of a previously normal umbilical artery. A third theory describes a persistence of the original allantoic artery of the body stalk as an explanation for SUA. Embryological considerations, as well as the detection of occluded remnants of a second umbilical artery in some SUA fetuses, suggest that the second theory is the most likely explanation. 1,4,5 In a review of eight studies of SUA in the literature, Persutte and Hobbins 1 reported an incidence of SUA in 1.5% in spontaneous abortuses, 7% of pregnancies that were terminated because of a serious malformation, 0.2% to 1.6% of euploid fetuses who underwent prenatal ultrasound examination, 9% to 11% of aneuploid fetuses, and 0.5% to 2.5% of uncomplicated neonates. The reported incidence of SUA varies depending on the method used to identify its occurrence, being highest in abortuses and autopsies and relatively low on ultrasound and in term neonates. 1,6 -8 Although there has been no evidence supporting any genetic etiology or familial tendency of this condition, it is known that SUA occurs more frequently in twin births (4.6%) versus singletons (1%). 4,9 The risk for congenital anomalies in infants with SUA also depends on the method of ascertainment, being highest at autopsy, but cases diagnosed at ultrasound or at t...

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“…However, in the presence of concurrent structural anomalies, chances of chromosomal anomalies being present are high. [48] The incidence of single umbilical artery is 0.2–1%. Probable etiologies include primary agenesis of one of the arteries, secondary atrophy of a previously normal artery, or persistence of the original single allantoic artery of the body stalk.…”

Section: Single Umbilical Arterymentioning

confidence: 99%

Fetal environment

Kinare

2008

Indian J Radiol Imaging

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The intrauterine environment has a strong influence on pregnancy outcome. The placenta and the umbilical cord together form the main supply line of the fetus. Amniotic fluid also serves important functions. These three main components decide whether there will be an uneventful pregnancy and the successful birth of a healthy baby. An insult to the intrauterine environment has an impact on the programming of the fetus, which can become evident in later life, mainly in the form of cardiovascular diseases, diabetes, and certain learning disabilities. The past two decades have witnessed major contributions from researchers in this field, who have included ultrasonologists, epidemiologists, neonatologists, and pediatricians. Besides being responsible for these delayed postnatal effects, abnormalities of the placenta, umbilical cord, and amniotic fluid also have associations with structural and chromosomal disorders. Population and race also influence pregnancy outcomes to some extent in certain situations. USG is the most sensitive imaging tool currently available for evaluation of these factors and can offer considerable information in this area. This article aims at reviewing the USG-related developments in this area and the anatomy, physiology, and various pathologies of the placenta, umbilical cord, and the amniotic fluid.

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Prenatal sonographic diagnosis of single umbilical artery

Cited by 21 publications

References 13 publications

Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta‐analysis

Relationship of isolated single umbilical artery to fetal growth, aneuploidy and perinatal mortality: systematic review and meta‐analysis

Single umbilical artery: What does it mean for the fetus? A case-control analysis of pathologically ascertained cases

Fetal environment

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