Prenatal selenium status, neonatal cerebellum measures and child neurodevelopment at the age of 18 months

Močenić, Ivona; Kolić, Ivana; Nišević, Jelena Radić; Belančić, Andrej; Tratnik, Janja Snoj; Mazej, Darja; Falnoga, Ingrid; Vlašić-Cicvarić, Inge; Štimac, Tea; Špirić, Zdravko; Horvat, Milena; Prpić, Igor

doi:10.1016/j.envres.2019.108529

Cited by 21 publications

(12 citation statements)

References 37 publications

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“…In a recent Croatian study aiming to evaluate the association of maternal and cord blood Se levels with neonatal cerebellum measures and child neurodevelopment at the age of 18 months, 205 mother-child pairs from the Croatian Mother and Child Cohort were investigated [30]. Mean Se levels in maternal blood and cord blood were 92.6 ng/g and 97.0 ng/g, respectively.…”

Section: Se and Impact On The Fetus And Childmentioning

confidence: 99%

Selenium and at-risk pregnancy: challenges and controversies

Duntas

2020

Thyroid Res

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Selenium (Se), an essential trace element, is inserted as selenocysteine into an array of functional proteins and forms the core of various enzymes that play a cardinal role in antioxidant defense mechanisms, in redox regulation, and in thyroid hormone metabolism. Variations in plasma Se are due to nutritional habits, geographic and ethnic differences, and probably to genetic polymorphisms, the latter still to be conclusively established. Se concentrations were reported to be low in women of reproductive age in the UK, decreasing further during pregnancy, this resulting in low plasma and placental antioxidant enzyme activities. Since low serum Se levels have been found in women with preeclampsia, it has been hypothesized that low maternal Se status during early gestation may be an indicator of preterm birth. Moreover, it is documented that Se administration during pregnancy tendentially reduced the markers of thyroid autoimmunity and the incidence of maternal hypothyroidism in the postpartum period. Importantly, low Se levels in pregnant women affect fetal growth and augment the risk of delivering a small-for-gestational age infant by reducing placental antioxidant defense, while low Se in the third trimester is thought to indicate increased demands by the placenta, an issue which requires further confirmation. There is evidently a need for double-blind, placebo-controlled studies to better determine the efficacy and safety of Se supplementation in pregnancy at high risk for complications, and for measurement of Se levels or of selenoprotein P, the most reliable parameter of Se status, particularly in selenopenic regions.

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Section: Se and Impact On The Fetus And Childmentioning

confidence: 99%

Selenium and at-risk pregnancy: challenges and controversies

Duntas

2020

Thyroid Res

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“…Maternal Se deficiency is associated with decreased neonatal Se status, which increases the risk for multiple neonatal morbidities [11,18,52,53]. This suggests an important role for Se during embryonic and neonatal development.…”

Section: Discussionmentioning

confidence: 99%

“…Malnutrition before and during pregnancy regulates the supply of macro-and micronutrients to the fetus, which can result in poor outcomes for the infant [1][2][3][4]. Clinical studies have linked deficiency of the micronutrient selenium (Se) to multiple neonatal morbidities, including sepsis, impaired neurodevelopment, poor postnatal growth, bronchopulmonary dysplasia, and retinopathy of prematurity [5][6][7][8][9][10][11]. Se is a trace mineral essential for redox homeostasis and response to oxidative stress [12,13].…”

Section: Introductionmentioning

confidence: 99%

Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency

et al. 2021

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Maternal selenium (Se) deficiency is associated with decreased neonatal Se levels, which increases the risk for neonatal morbidities. There is a hierarchy to selenoprotein expression after Se deficiency in adult rodents, depending on the particular protein and organ evaluated. However, it is unknown how limited Se supply during pregnancy impacts neonatal selenoprotein expression. We used an Se-deficient diet to induce perinatal Se deficiency (SeD), initiated 2–4 weeks before onset of breeding and continuing through gestation. Neonatal plasma, liver, heart, kidney, and lung were collected on the day of birth and assessed for selenoproteins, factors required for Se processing, and non-Se containing antioxidant enzymes (AOE). Maternal SeD reduced neonatal circulating and hepatic glutathione peroxidase (GPx) activity, as well as hepatic expression of Gpx1 and selenophosphate synthetase 2 (Sps2). In contrast, the impact of maternal SeD on hepatic thioredoxin reductase 1, hepatic non-Se containing AOEs, as well as cardiac, renal, and pulmonary GPx activity, varied based on duration of maternal exposure to SeD diet. We conclude that the neonatal liver and circulation demonstrate earlier depletion in selenoenzyme activity after maternal SeD. Our data indicate that prolonged maternal SeD may escalate risk to the neonate by progressively diminishing Se-containing AOE across multiple organs.

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“…Nutrient deficiencies are common during the early adoption period in international adoptees from three global regions, and iron and zinc deficiencies are associated with poorer neurodevelopmental outcomes [12]. Prenatal selenium intake is associated with cerebellum length and width measured by cranial ultrasonography [13]. Long-term dietary variation in selenium influences oxidative stress that impacts cognitive functions [14].…”

Section: Discussionmentioning

confidence: 99%

Physicians' Understanding of Nutritional Factors Determining Brain Development and Cognition in the Middle East and Africa

Vandenplas

Rakhecha

Edris

et al. 2019

Pediatr Gastroenterol Hepatol Nutr

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Purpose: Proper nutrition is essential for brain development during infancy, contributing to the continued development of cognitive, motor, and socio-emotional skills throughout life. Considering the insufficient published data in the Middle East and North Africa, experts drafted a questionnaire to assess the opinions and knowledge of physicians on the impact of nutrition on brain development and cognition in early life. Methods: The questionnaire consisted of two parts: The first focused on the responders' demographic and professional characteristics and the second questioned the role of nutrition in brain development and cognition. Descriptive statistics were used to summarize respondents' characteristics and their responses to questions. Results: A total of 1,500 questionnaires were distributed; 994 physicians responded. The majority of the surveyed physicians (64.4%) felt that nutrition impacts brain development in early childhood (0-4 years), with almost 90% of physicians agreeing/strongly agreeing that preventing iron, zinc, and iodine deficiency would improve global intelligence quotient. The majority of physicians (83%) agreed that head circumference was the most important measure of brain development. The majority of physicians (68.9%) responded that the period from the last trimester until 18 months postdelivery was crucial for brain growth and neurodevelopment, with 76.8% believing that infants breast-fed by vegan mothers have an increased risk of impaired brain development.

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Prenatal selenium status, neonatal cerebellum measures and child neurodevelopment at the age of 18 months

Cited by 21 publications

References 37 publications

Selenium and at-risk pregnancy: challenges and controversies

Selenium and at-risk pregnancy: challenges and controversies

Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency

Physicians' Understanding of Nutritional Factors Determining Brain Development and Cognition in the Middle East and Africa

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