Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates

Zhang, Jie; Yoshinaga, Jun; Hisada, Aya; Shiraishi, Hiroaki; Shimodaira, Kazuhisa; Okai, Takashi; Koyama, Maiko; Watanabe, Noriko; Suzuki, Eiji; Shirakawa, Miyako; Noda, Yumiko; Komine, Yoko; Ariki, Nagako; Kato, Nobuo

doi:10.1016/j.scitotenv.2014.04.104

Cited by 26 publications

(26 citation statements)

References 26 publications

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“…In Table 2 , mean and median of urinary 3-PBA concentration (specific gravity adjusted), blood TSH concentration 5 days postpartum, DQ, and ICCE of the 102 subjects (mother or infant) of this study are given. Urinary 3-PBA and blood TSH concentrations of all subjects measured for this cohort have already been reported [ 18 ] and the values presented in Table 2 are those of the subpopulation.…”

Section: Resultsmentioning

confidence: 94%

“…Of the 231, 37 left cohort by the time of delivery for the following reasons: spontaneous abortion (7), change of hospital (12), multiple pregnancies (8), and refusal or other reasons (10). Of these, 147 neonates supplied blood 5 days postpartum [ 18 ], and 132 of the mother–baby pairs were followed after delivery until the baby was 18 months of age. All of the data used in the present analysis were obtained from only 102 of the 132 pairs due to missing data for some subjects.…”

Section: Methodsmentioning

confidence: 99%

“…Thyroid stimulating hormone (TSH) concentration in neonatal blood was measured by enzyme-linked immunosorbent assay (ELISA): blood was sampled from the heel of the neonate 5 days postpartum on filter paper and subjected to TSH analysis [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

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Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age

Hisada

Yoshinaga

Zhang

et al. 2017

IJERPH

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The possible association between maternal exposure to pyrethroid insecticides (PYRs) during pregnancy and infant development was explored. Levels of exposure to PYRs was assessed by metabolite (3-phenoybenzoic acid, 3-PBA) concentration in maternal spot urine sampled in the first trimester of index pregnancy, and infant development was assessed at 18 months of age using the Kinder Infants Development Scale (KIDS), which is based on a questionnaire to the caretaker. The relationship between KIDS score and maternal urinary 3-PBA levels was examined by a stepwise multiple regression analysis using biological attributes of the mother and infant, breast feeding, and nursing environment as covariates. The analysis extracted 3-PBA and the nursing environment as significant to explain the KIDS score at 18 months of age with positive partial regression coefficients. Inclusion of fish consumption frequency of the mother during pregnancy as an independent variable resulted in the selection of fish consumption as significant, while the two variables were marginally insignificant but still with a positive coefficient with the KIDS score. The result suggested a positive effect of maternal PYR exposure on infant development, the reason for which is not clear, but an unknown confounding factor is suspected.

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Section: Resultsmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

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Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age

Hisada

Yoshinaga

Zhang

et al. 2017

IJERPH

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“…The major route of exposure for humans is through ingestion of food items treated with PYRs (151). Even though PYRs have relative short half-lives ranging from 3-to 96-days in soil (152), they are found in environmental samples (153,154), human samples (155) and food (156), probably as a result of excessive and repeated use. Given PYRs structural resemblance to T3 and T4, PYRs insecticides are suspected to act as TH disruptors (150).…”

Section: Pyrethroidsmentioning

confidence: 99%

“…As determined by urinary levels of metabolites to estimate internal exposure, human exposure to PYRs is widespread (155). Pregnant women are of particular concern given the vulnerable window of prenatal exposure to pesticides that could lead to impairment of normal development of offspring.…”

Section: Epidemiological Evidence Of Thyroid Disruptionmentioning

confidence: 99%

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield-reducing pests including insects, fungi, nematodes, and weeds. Concern has been raised that some pesticides may act as endocrine disrupting chemicals (EDCs) with the potential to interfere with the hormone systems of non-target invertebrates and vertebrates, including humans. EDCs act at low doses and particularly vulnerable periods of exposure include pre-and perinatal development. Of critical concern is the number of pesticides with the potential to interfere with the developing nervous system and brain, notably with thyroid hormone signaling. Across vertebrates, thyroid hormone orchestrates metamorphosis, brain development, and metabolism. Pesticide action on thyroid homeostasis can involve interference with TH production and its control, displacement from distributor proteins and liver metabolism. Here we focused on thyroid endpoints for each of the different classes of pesticides reviewing epidemiological and experimental studies carried out both in in vivo and in vitro. We conclude first, that many pesticides were placed on the market with insufficient testing, other than acute or chronic toxicity, and second, that thyroid-specific endpoints for neurodevelopmental effects and mixture assessment are largely absent from regulatory directives.

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Human Risk Associated with Long-Term Exposure to Pyrethroid Insecticides

Saillenfait

Malard

2020

The Handbook of Environmental Chemistry

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The aim of this review is to provide a broad summary of the latest state of knowledge about the potential long-term adverse effects of pyrethroids on human health. The oldest and recent epidemiological studies mainly addressed respiratory, neurological, hormonal, and reproductive outcomes in adults after environmental and occupational exposures. Although several of these studies have suggested negative effects, especially on male hormonal and sperm parameters, findings were often equivocal or inconsistent across studies, and no firm and reliable conclusions can be reached yet. Regarding developmental outcomes, there is increasing evidence that fetal exposure to pyrethroids may be associated with poorer children's neurodevelopment. Prevention measures should be considered to reduce exposure of pregnant women and children to these widely used insecticides.

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Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates

Cited by 26 publications

References 26 publications

Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age

Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Human Risk Associated with Long-Term Exposure to Pyrethroid Insecticides

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