Prenatal protein malnutrition affects synaptic potentiation in the dentate gyrus of rats in adulthood

Austin, Kevin; Bronzino, Joseph D.; Morgane, Peter J.

doi:10.1016/0165-3806(86)90102-1

Cited by 76 publications

(25 citation statements)

References 30 publications

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“…1–4 Electrophysiological studies have demonstrated that malnutrition impairs the establishment and maintenance of long-term potentiation, a mechanism that is believed to underlie learning and memory processes in the hippocampus. 5–7 In agreement with this, behavioral studies indicate that some aspects of learning and memory may be altered in the prenatally malnourished rat. 8 More recent work with benzodiazepines reveals involvement of the GABAergic system; prenatally protein malnourished rats are less sensitive to the amnestic effects of moderate doses of chlordiazepoxide, a non-selective benzodiazepine agonist, whether applied systemically 9 or applied directly to the medial septum.…”

Section: Introductionsupporting

confidence: 66%

Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat

Lister

Blatt

Kemper

et al. 2011

Nutritional Neuroscience

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Prenatal protein malnutrition alters the structure and function of the adult rat hippocampal formation. The current study examines the effect of prenatal protein malnutrition on numbers of parvalbumin-immunoreactive (PV-IR) GABAergic interneurons, which are important for perisomatic inhibition of hippocampal pyramidal neurons. Brain sections from prenatally protein malnourished and normally nourished rats were stained for parvalbumin and PV-IR neurons were quantified using stereology in the dentate gyrus, CA3/2 and CA1 subfields, and the subiculum for both cerebral hemispheres. Results demonstrated that prenatal malnutrition did not affect the number of PV-IR interneurons in the hippocampus. Since prenatal protein malnutrition reduces total neuron numbers in the CA1 subfield (1), this results in an altered ratio of PV-IR interneurons to total neuronal numbers (from 1:22.9 in controls to 1:20.5 in malnourished rats). Additionally, there was no hemispheric asymmetry of either PV-IR neuron numbers or ratio of PV-IR:total neuron numbers.

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Section: Introductionsupporting

confidence: 66%

Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat

Lister

Blatt

Kemper

et al. 2011

Nutritional Neuroscience

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“…However, in spite of the apparently normal body and brain fetal development, hidden prenatally-malnourished rats showed impaired occipital cortex LTP in adult life, as transcallosal responses evoked in the occipital cortex of malnourished rats were unable to become potentiated for more than 5 min after tetanization. This is in agreement with previous studies showing that prenatally malnourished rats had impaired capacity to elicit and/or maintain (LTP) in the hippocampus (Austin, Bronzino, & Morgane, 1986) as well as in the occipital, frontal and entorhinal neocortices (Hernández et al, 2008;Soto-Moyano et al, 2005). Besides, the foregoing results showed that the occipital cortex of the malnourished animals had higher binding of [ 3 H]-rauwolscine in the occipital cortex (about twice Bmax value) than that observed in normal controls of the same age, which is consistent with the already reported overexpression of a 2C -adrenoceptors in the neocortex of hidden prenatally malnourished rats (Soto-Moyano et al, 2005).…”

Section: Discussionsupporting

confidence: 94%

Knockdown of α2C-adrenoceptors in the occipital cortex rescued long-term potentiation in hidden prenatally malnourished rats

Barra

Soto-Moyano

Valladares

et al. 2012

Neurobiology of Learning and Memory

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“…The population spike amplitude and EPSP slope measures obtained at each intensity were then calculated from the averaged waveforms and graphed as a function of stimulus intensity. Previous studies in this laboratory have indicated that the level of local GABAergic inhibi-tory modulation of granule cell activity is dependent upon the intensity of perforant path stimulation and related to the amplitude of the granule cell response (Austin et al, 1986). For this reason we investigated the existence of possible developmental changes in the response level of dentate granule cells as a function of stimulus intensity by utilizing two intensities, i.e., stimulus intensities required to evoke population responses equal to 40% and 75% of the maximum population spike amplitude.…”

Section: Determination Of Input/output (I/o) Response Curvementioning

confidence: 99%

Maturation of long‐term potentiation in the hippocampal dentate gyrus of the freely moving rat

et al. 1994

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The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (long-term potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1) the slope of the population excitatory postsynaptic potential (EPSP), and 2) the population spike amplitude (PSA) obtained before, and at several times following tetanization, were used to evaluate the magnitude and duration of LTP as a function of age. Significant enhancement of both EPSP slope and PSA measures was obtained from animals of all three ages in response to perforant path tetanization. The initial degree of enhancement was essentially the same across the age groups, ranging from +27% to +38% of pretetanization levels for EPSP slope measures and +60% to +75% of pretetanization levels for PSA measures, obtained 15 min after tetanization. The duration of this enhancement obtained from animals of the preweaning group was significantly longer than that obtained from either 30- or 90-day-old animals. Enhanced measures of both EPSP slope and PSA decayed to baseline levels in these older animals 18 to 24 h after tetanization, while animals tetanized at 15 days of age maintained potentiated levels of both measures for a period of 5 days following tetanization. Tetanization of 15-day-old animals resulted in a significant reduction in the latency to EPSP onset without affecting the time-based relationships among the other measured parameters, which included latency of the population spike onset, population spike minimum, and population spike offset.(ABSTRACT TRUNCATED AT 250 WORDS)

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Prenatal protein malnutrition affects synaptic potentiation in the dentate gyrus of rats in adulthood

Cited by 76 publications

References 30 publications

Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat

Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat

Knockdown of α2C-adrenoceptors in the occipital cortex rescued long-term potentiation in hidden prenatally malnourished rats

Maturation of long‐term potentiation in the hippocampal dentate gyrus of the freely moving rat

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