Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight

Sonneborn, Dean; Park, Hye Youn; Petrı́k, Ján; Kočan, Anton; Palkovičová, Ľubica; Trnovec, T.; Nguyen, Danh V.; Hertz‐Picciotto, Irva

doi:10.1111/j.1365-3016.2008.00929.x

Cited by 67 publications

(79 citation statements)

References 55 publications

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“…There were few results reported gender difference, they frequently indicated a stronger negative effect on the birth weight among male infants (Rylander et al, 1996;Baibergenova et al, 2003;Sonneborn et al, 2008;Hertz-Picciotto et al, 2005;Vartiainen et al, 1998). Previous reports have indicated that increased maternal serum PCBs levels are associated with reduced birth weight in male infants and have suggested a greater susceptibility of male conceptuses, either in the fetal or embryonic period (Sonneborn et al, 2008;Hertz-Picciotto et al, 2005). Some of the studies reporting gender difference in the PCBs effects did not actually measure PCBs levels, but used a surrogate for exposure such as estimated fish consumption (Rylander et al, 1996) or residential information (Baibergenova et al, 2003), which may entail greater errors in exposure classification.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies of lower-level PCBs exposure during pregnancy observed associations with decreased birth weight and other growth parameters (Fein et al, 1984;Rylander et al, 1996: Rylander et al, 1998Patandin et al, 1998;Karmaus and Zhu, 2004;Hertz-Picciotto et al, 2005;Sagiv et al, 2007;Sonneborn et al, 2008). In the Lake Michigan fish consumer study, cord serum PCBs levels predicted LBW and smaller birth head circumference (Fein et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, reported results on the relationship between birth weight and the levels of PCDDs/PCDFs and DL-PCBs are currently limited and inconsistent. Furthermore, some studies have reported a difference between genders with regard to the effects of PCBs and PCDDs/PCDFs on birth outcomes (Rylander et al, 1996;Baibergenova et al, 2003;Sonneborn et al, 2008;Hertz-Picciotto et al, 2005;Vartiainen et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes.However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies.A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood.Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% CI: -387.4 to -61.5).Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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“…Pregnant and nursing women may pass the dioxins and/or PCBs to their newborns via transplacental transfer and by breastfeeding mothers (Suzuki et al 2005, Wang et al 2004. Several studies on exposure to lower levels of dioxins or PCBs during pregnancy have shown a relationship with low birth weight and other growth parameters (HertzPicciotto et al 2005, Patandin et al 1998, Sonneborn et al 2008). …”

Section: Introductionmentioning

confidence: 99%

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Tung

Kido

Honma

et al. 2016

Environ Sci Pollut Res

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We aimed to determine the relationship between dioxin congeners in maternal breast milk and maternal glucocorticoid levels with newborn birth weight after nearly 45 years of use of herbicides in the Vietnam War. The study subjects comprised 58 mother-infant pairs in a region with high dioxin levels in the soil (hotspot) and 62 pairs from a control region. Dioxin levels in maternal breast milk were measured by HRGC-HRMS. Salivary glucocorticoid levels were determined by LC-MS/MS. Dioxin congener levels in mothers from the hotspot were found to be 2-5-fold higher than those in mothers from the control region. Birth weight was inversely correlated with 2,3,7,8-TeCDD and 2,3,4,7,8-PeCDF congener levels. The rate of newborns whose birth weight was less than 2500 g was 3-fold higher in the hotspot (12%) than in the control region (4%). Salivary glucocorticoid levels in mothers with low birth weight infants were significantly higher than those in the normal birth weight group. Low birth weight of Vietnamese newborns in a hotspot for dioxin levels is related to some dioxin congener levels and high glucocorticoid levels in mothers. This finding in mother-infant pairs suggests that excess maternal glucocorticoid levels are related to dioxin burden and they result in low birth weight.

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“…These studies mainly originate in the northern and western parts of Europe with only studies published in the Czech and Slovak Republics of the Danube area (11)(12)(13). Globally much attention is toward birth cohorts …”

Section: Introductionmentioning

confidence: 99%

Perinatal health in the Danube region – new birth cohort justified

Knudsen

Andersen

Šrám³

et al. 2017

Reviews on Environmental Health

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Abstract In 2013–2015, a consortium of European scientists – NEWDANUBE – was established to prepare a birth cohort in the Danube region, including most of the countries with the highest air pollution in Europe, the area being one-fifth of the European Union’s (EU’s) territory, including 14 countries (nine EU member states), over 100 million inhabitants, with numerous challenges: big socioeconomic disparities, and a region-specific environmental pollution. The consortium reflects the EU Strategy for the Danube Region Strategy (2010), which identified 11 thematic Priority Areas – one of which is the environmental risks. Birth cohorts have been established in all other areas of Europe and collaborative efforts in promoting maternal and fetal health by minimizing the environmental exposures have been initiated with national, European, and international financial support. A birth cohort in the Danube area could apply the established methodologies for prenatal exposure and birth outcome measurements and establish a platform for targeted health promotion in couples planning pregnancies. The consortium included a strong socioeconomic part focusing on the participant’s active registration of exposures to environmental toxicants and health indicators of disease and wellbeing, combined with investigation of their risk-reducing behavior and interventions to change their lifestyle to avoid the adverse health risks. Willingness to pay for reducing the health risks in children is also proposed to be estimated. Further collaboration and networking is encouraged as the Danube region has several decades of experience and expertise in biomonitoring adult populations exposed environmentally or occupationally. Additionally, some countries in the Danube region launched small-scale birth cohorts encouraged by participation in several ongoing research projects.

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Prenatal polychlorinated biphenyl exposures in eastern Slovakia modify effects of social factors on birthweight

Cited by 67 publications

References 55 publications

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Perinatal health in the Danube region – new birth cohort justified

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