Prenatal phthalate exposure and placental size and shape at birth: A birth cohort study

Zhu, Yuanduo; Gao, Hui; Huang, Kun; Zhang, Yunwei; Cai, Xiaopan; Hui-yuan, Yao; Mao, Leijing; Ge, Xing; Zhou, Shusheng; Xu, Yuanyuan; Zhang, Jin; Sheng, Jie; Yan, Shuangqin; Pan, Weijun; Hao, Jiahu; Zhu, Peng; Tao, Fangbiao

doi:10.1016/j.envres.2017.09.012

Cited by 44 publications

(28 citation statements)

References 32 publications

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“…In humans, Zhu et al [23], studying mother urinary phathalate excretion in the three trimesters of pregnancy, suggested that prenatal phthalate exposure was associated with altered placental size and shape, and that exposure to certain phthalates could induce the placenta to become thicker and more circular. Moreover, the associations observed appeared stronger in the males.…”

Section: From Environment To Pregnant Mothermentioning

confidence: 99%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

111

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Fetal growth is regulated by a complex interaction of maternal, placental, and fetal factors. The effects and outcomes that chemicals, widely distributed in the environment, may have on the health status of both the mother and the fetus are not yet well defined. Mainly mixtures of chemical substances are found in the mothers and placenta. Exposure to endocrine-disrupting chemicals (EDCs) can be associated with fetal growth retardation, thyroid dysfunction, and neurological disorders. EDCs mostly interfere with insulin, glucocorticoid, estrogenic, and thyroid pathways, with subsequent effects on normal endocrine and metabolic functions, which cause changes in the epigenome and state of inflammation with life-long effects and consequences. International scientific societies recommend the implementation of research and of all possible preventive measures. This review briefly summarizes all these aspects.

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Section: From Environment To Pregnant Mothermentioning

confidence: 99%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

111

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“…For example, positive associations of placental thickness with phthalates in the second trimester (MBP, MEHP, MEHHP, and LMWP) and third trimester (MBP and MEHP) were driven by effects in males. Furthermore, in repeated measures analyses, increased MBP, MEHP, MEOHP, LMWP, and HMWP concentrations were associated with larger placental thickness in males, while higher MBP, MEHP, and MEHHP concentrations were associated with longer placental length in females [ 113 ]. David Barker was one of the first to suggest that placental morphology (size, width, breadth) is an important predictor of fetal development [ 114–116 ].…”

Section: Sex-specific Placental Outcomesmentioning

confidence: 99%

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta

Strakovsky

Schantz

2018

Environmental Epigenetics

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The placenta guides fetal growth and development. Bisphenol A (BPA) and phthalates are widespread environmental contaminants and endocrine disruptors, and the placental epigenetic response to these chemicals is an area of growing research interest. Therefore, our objective was to summarize research linking BPA or phthalate exposure to placental outcomes in human pregnancies, with a particular focus on epigenetic endpoints. In PubMed, studies were selected for review (without limiting start date and ending on 1 May 2018) if they reported any direct effects of BPA or phthalates on the placenta in humans. Collectively, available studies suggest that BPA and phthalate exposures are associated with changes to placental micro-RNA expression, DNA methylation, and genomic imprinting. Furthermore, several studies suggest that fetal sex may be an important modifier of placental outcomes in response to these chemicals. Studies in humans demonstrate associations of BPA and phthalate exposure with adverse placental outcomes. Moving forward, more studies should consider sex differences (termed “placental sex”) in the measured outcomes, and should utilize appropriate statistical approaches to assess modification by fetal sex. Furthermore, more consistent sample collection and molecular outcome assessment paradigms will be indispensable for making progress in the field. These advances, together with improved non-invasive tools for measuring placental function and outcomes across pregnancy, will be critical for understanding the mechanisms driving placental epigenetic disruption in response to BPA and phthalates, and how these disruptions translate into placental and fetal health.

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“…2013; CDC 2014). Data regarding associations between these compounds and markers of placental growth in humans are sparse (Zhu et al. 2018; Ferguson et al.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France)

Philippat

Heude

Botton

et al. 2019

Environ Health Perspect

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Background: The placenta performs crucial physiological functions to ensure normal fetal development. Few epidemiological studies investigated placental weight sensitivity to phthalates and phenols. Objective: Our goal was to explore whether maternal exposure to select phthalates and phenols is associated with changes in placental weight at birth and in placental–to–birth weight ratio (PFR). Methods: Placental weight and birth weight were available for 473 mother–son pairs in the EDEN (Etude des Déterminants pré et postnatals du développement et de la santé de l’Enfant) cohort for whom 9 phenols (4 parabens, 2 dichlorophenols, triclosan, benzophenone-3, bisphenol A) and 11 phthalate metabolites were measured in spot urine samples collected between weeks 23 and 29 of gestation. We used adjusted Elastic Net penalized regression models (ENET) to select biomarkers associated with placental weight, birth weight and PFR. Unpenalized effect estimates were then obtained by fitting linear regression models simultaneously adjusted for the ENET-selected biomarkers and a priori chosen confounders. Results: The multipollutant ENET model for placental weight retained four biomarkers: triclosan and monocarboxy-isononyl phthalate (MCNP), which were negatively associated with placental weight, and benzophenone-3 and the sum of parabens, which were positively associated with this outcome. The ENET model for PFR retained two phthalate metabolites [MCNP and monocarboxy-isooctyl phthalate (MCOP)], which were negatively associated with this outcome. Discussion: The positive association between the sum of parabens and placental weight was consistent with results of a previous study among 49 male births. Our results provide preliminary evidence of possible associations between other compounds such as triclosan, benzophenone-3, MCNP, and MCOP and both placental weight and PFR. These associations were not reported in previous studies and should be seen as hypothesis generating. Studies relying on repeated assessments of exposure in prospective mother–child cohorts are needed to substantiate the plausibility of the hypotheses generated by our results. https://doi.org/10.1289/EHP3523

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Prenatal phthalate exposure and placental size and shape at birth: A birth cohort study

Cited by 44 publications

References 32 publications

Endocrine-Disrupting Chemicals in Human Fetal Growth

Endocrine-Disrupting Chemicals in Human Fetal Growth

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta

Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France)

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