Prenatal phthalate exposure and early childhood wheeze in the SELMA study

Preece, Anna Sofia; Knutz, Malin; Lindh, Christian; Bornehag, Carl‐Gustaf; Shu, Huan

doi:10.1038/s41370-021-00382-w

Cited by 14 publications

(1 citation statement)

References 47 publications

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“…In recent years, some studies have found the concentration of dibutyl phthalate (DBP) was high in indoor air, and its inhalation may contribute to more than 20% of the daily internal dose of the phthalates [ 8 , 9 ]. Therefore, researchers have realized that phthalates were related with the development of respiratory diseases in recent years [ 6 , 10 ]. Although there was no direct approach to detect phthalates concentration in human lung tissues, urinary phthalates concentration has been demonstrated to be a good biomarker of phthalates exposure.…”

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confidence: 99%

The Association between Daily Dietary Intake of Riboflavin and Lung Function Impairment Related with Dibutyl Phthalate Exposure and the Possible Mechanism

et al. 2022

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This study aimed to evaluate the relationship between the daily dietary intake of riboflavin (DDIR) and impaired lung function associated with dibutyl phthalate (DBP) exposure. Data of 4631 adults in this national cross-sectional survey were included. Urinary mono-benzyl phthalate (MBP) was used to evaluate the level of DBP exposure. The ln-transformed urinary creatinine-corrected MBP (ln(MBP/UCr)) level was used in the statistical models. High DDIR was defined as the DDIR ≥1.8 mg per day. The results of lung function impairment and high monocytes were significantly higher in the highest MBP group compared with the lowest MBP group. A significant interaction between ln(MBP/UCr) and DDIR (Pinteraction = 0.029) was detected for the risk of lung function impairment. The risk of lung function impairment (ORquartiles4 vs. 1 1.85, 95% CI, 1.27–2.71; Ptrend = 0.018) and high neutrophils (ORquartiles4 vs. 1 1.45, 95% CI, 1.06–1.97; Ptrend = 0.018) was significantly higher in the highest vs. the lowest quartile of MBP in participants with low/normal DDIR but not in in participants with high DDIR. The results of this study showed that high DDIR was associated with less lung function impairment related with DBP exposure, and the inhibiting of the neutrophil recruitment might be the potential mechanism.

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